45347-82-8

Basic information

• Product Name: 3-AZETIDINOL
• Synonyms: 3-AZETIDINOL;AZETIDIN-3-OL;3-Hydroxyazetidine;(S)-methyl 2,2-dimethyl-1,3-dioxolane-4-carboxylate;Azetidin-3-ol, 3-Hydroxyazetane;3-AZETIDINOLHCL
• CAS NO: 45347-82-8
• Molecular Formula: C₃H₇NO
• Molecular Weight: 73.09
• Mol File: 45347-82-8.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 170.7 °C at 760 mmHg
• Flash Point: 120.4 °C
• Appearance: /
• Density: 1.142 g/cm³
• Vapor Pressure: 0.464mmHg at 25°C
• Refractive Index: 1.498
• Storage Temp.: 2-8°C(protect from light)
• PKA: 14.51±0.20(Predicted)
• CAS DataBase Reference: 3-AZETIDINOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AZETIDINOL(45347-82-8)
• EPA Substance Registry System: 3-AZETIDINOL(45347-82-8)

Safety Data

• Hazardous Substances Data: 45347-82-8(Hazardous Substances Data)

Usage

General Description

3-Azetidinol, also known as 3-Hydroxyazetidine, is a chemical compound with the molecular formula C3H7NO. It is a cyclic secondary amine with a four-membered ring structure containing an oxygen atom and a hydroxyl group. 3-Azetidinol is used in organic synthesis as a chiral building block for the production of pharmaceutical and agrochemical products. It is also utilized as a ligand in asymmetric catalysis due to its ability to efficiently transfer chirality to a target molecule. Additionally, 3-Azetidinol has potential applications in the development of new materials and in the field of medicinal chemistry for the design of bioactive compounds. Overall, this versatile chemical shows promise in various industries and research fields due to its unique molecular structure and beneficial properties.

InChI:InChI=1/C3H7NO/c5-3-1-4-2-3/h3-5H,1-2H2

Upstream product

• 18621-17-5 1-(diphenylmethyl)-3-hydroxyazetidine 
• 616-30-8 3-Amino-1,2-propanediol 
• 141699-55-0 tert-butyl 3-hydroxyazetidine-1-carboxylate 
• 111043-42-6 N-benzyl-3-(trimethylsilyloxy)azetidine 

Downstream Products

• 141699-55-0 tert-butyl 3-hydroxyazetidine-1-carboxylate 
• 1146157-51-8 1-(4-isopropylbenzyl)azetidin-3-ol 
• 1307871-86-8 C₂₇H₂₈N₄O₅S₂ 
• 1333151-95-3 (Z)-azetidin-3-yl 3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate 
• 1353625-21-4 C₂₃H₂₇BrN₆O₄S 
• 1353623-40-1 C₂₅H₃₀ClN₇O₄S 
• 1165800-49-6 C₂₆H₃₆N₄O₄ 
• 1246361-60-3 tert-butyl (2R)-1-(4'-(3-hydroxyazetidine-1-carbonyl)biphenyl-4-yl)-4-(3-(1-(3-methoxypropyl)-1H-indol-2-yl)piperidin-1-yl)-4-oxobutan-2-ylcarbamate 
• 857280-53-6 1-phenylazetidin-3-ol 
• 1196669-79-0 C₂₈H₂₉N₅O₂S 
• 1206638-31-4 (3-hydroxyazetidin-1-yl)(4-(8-(4-(3-hydroxyazetidine-1-carbonyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)phenyl)methanone 
• 1138041-12-9 1-{[4-(2-fluoropyridin-3-yl)-5-(phenylsulfonyl)thiophen-2-yl]methyl}azetidin-3-ol 
• 919300-10-0 1-(2,6-difluoro-4-nitro-phenyl)azetidin-3-ol 
• 919357-22-5 1-(2,3,6-trifluoro-4-nitrophenyl)azetidin-3-ol 

Relevant articles and documents

AZETIDINE CYCLIC UREAS

Provided are azetidine cyclic urea compounds that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

JAK INHIBITOR

The present invention discloses a series of JAK inhibitors, and particularly discloses a compound of formula (I) or a pharmaceutically acceptable salt thereof and the use thereof in preparation of drugs for treating diseases related to JAK.

PYRIDINE DERIVATIVES AND APPLICATION OF ANTI-MACOBACTERIUM THEREOF

The present invention provides a series of pyridine derivatives and their preparation method and application thereof. The series of pyridine derivatives can be applied to treating mycobacterium-related diseases, especially to treatments of fatal mycobacterium-related diseases. The fatal diseases may be related to mycobacterium tuberculosis, mycobacterium bovis, mycobacterium avium, and mycobacterium marinum.