453518-19-9Relevant articles and documents
PROCESS FOR PREPARATION OF 2-AMINO-5-HYDROXY PROPIOPHENONE
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Page/Page column 33, (2020/07/31)
The present invention relates to a process for preparation of 2-Amino-5-hydroxypropiophenone, a key intermediate for the synthesis of camptothecin analogs including 7-Ethyl-10-hydroxycamptothecin (SN-38).
Method of Synthesizing Key Intermediates for the Production of Camptothecin Derivatives
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Page/Page column 5, (2008/12/08)
The present invention discloses a process for efficient production of 2-amino-5-hydroxypropiophenone corresponding to the AB ring part of camptothecin (CPT) skeleton, which is a key intermediate useful for the total synthesis of camptothecin analogs including 7-Ethyl-10-hydroxy camptothecin and novel intermediates thereof.
METHOD OF SYNTHESIZING CAMPTOTHECIN-RELATING COMPOUNDS
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Page 22-23, (2010/02/05)
The present invention is to prepare efficiently 2'-amino-5'-hydroxypropiophenone corresponding to the AB-ring part of camptothecin (CPT) skeleton and a tricyclic ketone corresponding to the CDE-ring part in order to provide efficiently CPT by the total synthesis, which is a starting material for irinotecan hydrochloride and various kinds of camptothecin derivatives, and to provide stably CPT and its derivatives.