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4704-94-3

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4704-94-3 Usage

Description

2-(HYDROXYMETHYL)-1,3-PROPANEDIOL, also known as Glycerol, is a simple polyol compound with a hydroxymethyl group and two hydroxyl groups attached to a three-carbon chain. It is a colorless, viscous liquid that is hygroscopic in nature and widely used across various industries due to its unique properties.

Uses

Used in Chemical Synthesis:
2-(HYDROXYMETHYL)-1,3-PROPANEDIOL is used as a reactant for the preparation of tetracyanocyclopentadienide amine salts. Its versatility as a reactant allows for the creation of various chemical compounds, contributing to its importance in the chemical industry.
In addition to the provided material, Glycerol has several other applications across different industries:
Used in Pharmaceutical Industry:
Glycerol is used as a solvent, sweetening agent, and humectant in the pharmaceutical industry. It is also utilized in the production of various drugs, including antifreeze and as a component in the formulation of certain elixirs and expectorants.
Used in Cosmetics and Personal Care Industry:
In the cosmetics and personal care industry, Glycerol is used as a moisturizer, humectant, and emollient in products such as lotions, creams, and toothpaste. Its ability to retain moisture makes it a valuable ingredient in skincare and hair care products.
Used in Food Industry:
Glycerol is used as a humectant, sweetener, and preservative in the food industry. It is commonly found in the production of confectionery, baked goods, and as a component in the formulation of certain beverages.
Used in Energy Industry:
Glycerol is used as a feedstock for the production of biofuels, such as biodiesel and bio-jet fuel. Its ability to be derived from renewable resources makes it a sustainable option for energy production.
Used in Textile Industry:
In the textile industry, Glycerol is used as a humectant, lubricant, and plasticizer in the manufacturing of various fabrics and fibers, enhancing their softness and flexibility.
These applications highlight the diverse uses of 2-(HYDROXYMETHYL)-1,3-PROPANEDIOL across different industries, showcasing its importance and versatility as a compound.

Synthesis Reference(s)

Synthesis, p. 742, 1987 DOI: 10.1055/s-1987-28072

Check Digit Verification of cas no

The CAS Registry Mumber 4704-94-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,7,0 and 4 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 4704-94:
(6*4)+(5*7)+(4*0)+(3*4)+(2*9)+(1*4)=93
93 % 10 = 3
So 4704-94-3 is a valid CAS Registry Number.
InChI:InChI=1/C4H10O3/c5-1-4(2-6)3-7/h4-7H,1-3H2

4704-94-3 Well-known Company Product Price

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  • Aldrich

  • (393657)  2-Hydroxymethyl-1,3-propanediol  97%

  • 4704-94-3

  • 393657-1G

  • 1,546.74CNY

  • Detail

4704-94-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Hydroxymethyl-1,3-propanediol

1.2 Other means of identification

Product number -
Other names 2-(Hydroxymethyl)propane-1,3-diol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4704-94-3 SDS

4704-94-3Synthetic route

2-Benzoyloxymethyl-1,3-propanediol dibenzoate
113967-50-3

2-Benzoyloxymethyl-1,3-propanediol dibenzoate

2-hydroxymethyl-1,3-propanediol
4704-94-3

2-hydroxymethyl-1,3-propanediol

Conditions
ConditionsYield
With sodium methylate In methanol for 20h; Heating;98%
With sodium methylate In methanol for 20h; Time; Reflux;90%
[2-(4-methoxyphenyl)-[1,3]dioxan-5-yl]methanol
465540-17-4

[2-(4-methoxyphenyl)-[1,3]dioxan-5-yl]methanol

2-hydroxymethyl-1,3-propanediol
4704-94-3

2-hydroxymethyl-1,3-propanediol

Conditions
ConditionsYield
With water; Selectfluor In acetonitrile at 20℃; for 5h;90%
methanetricarboxylic acid triethyl ester
6279-86-3

methanetricarboxylic acid triethyl ester

2-hydroxymethyl-1,3-propanediol
4704-94-3

2-hydroxymethyl-1,3-propanediol

Conditions
ConditionsYield
With dimethylsulfide borane complex 1.) reflux, 8 h, 2.) methanol, 15 h;83%
With lithium aluminium tetrahydride; diethyl ether
bis-(hydroxymethyl)-acetaldehyde
40364-80-5

bis-(hydroxymethyl)-acetaldehyde

2-hydroxymethyl-1,3-propanediol
4704-94-3

2-hydroxymethyl-1,3-propanediol

Conditions
ConditionsYield
With hydrogen; ruthenium In water at 25℃; under 2585.7 Torr; for 24h; Yield given;
PtO2 In water
formaldehyd
50-00-0

formaldehyd

acetaldehyde
75-07-0

acetaldehyde

A

2,2-di(hydroxymethyl)-acetic acid
68516-39-2

2,2-di(hydroxymethyl)-acetic acid

B

Pentaerythritol
115-77-5

Pentaerythritol

C

2-hydroxymethyl-1,3-propanediol
4704-94-3

2-hydroxymethyl-1,3-propanediol

D

α,α,α-tris(hydroxymethyl)acetic acid
2831-90-5

α,α,α-tris(hydroxymethyl)acetic acid

E

2-Hydroxymethyl-2-(methoxymethoxymethyl)-1,3-propandiol
68658-38-8

2-Hydroxymethyl-2-(methoxymethoxymethyl)-1,3-propandiol

F

trimethyleneglycol
504-63-2

trimethyleneglycol

Conditions
ConditionsYield
With calcium hydroxide Mechanism;
formaldehyd
50-00-0

formaldehyd

acetaldehyde
75-07-0

acetaldehyde

A

Pentaerythritol
115-77-5

Pentaerythritol

B

2-methyl-1.3-propanediol
2163-42-0

2-methyl-1.3-propanediol

C

2-hydroxymethyl-1,3-propanediol
4704-94-3

2-hydroxymethyl-1,3-propanediol

D

trimethyleneglycol
504-63-2

trimethyleneglycol

Conditions
ConditionsYield
With sodium hydroxide; sulfuric acid; hydrogen; 5% activated charcoal-supported ruthenium catalyst 1.) 25 deg C, 30 min, 2.) 50 psi, 25 deg C, 4 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
With sodium hydroxide; sulfuric acid; hydrogen; Ru-carbon 1.) 25 deg C, 30 min, 2.) 50 psi, 25 deg C 4 h; Yield given. Multistep reaction. Yields of byproduct given;
formaldehyd
50-00-0

formaldehyd

acrolein
107-02-8

acrolein

A

2-hydroxymethyl-1,3-propanediol
4704-94-3

2-hydroxymethyl-1,3-propanediol

B

trimethyleneglycol
504-63-2

trimethyleneglycol

Conditions
ConditionsYield
With sulfuric acid; hydrogen; iron(II) sulfate; palladium on activated charcoal; Ru-carbon 1.) 25 deg C, 5 h, 2.) 50 psi, 25 deg C, 42 h; Yield given. Multistep reaction. Yields of byproduct given;
glycerol tristearate
555-43-1

glycerol tristearate

A

2-hydroxymethyl-1,3-propanediol
4704-94-3

2-hydroxymethyl-1,3-propanediol

B

stearic acid
57-11-4

stearic acid

Conditions
ConditionsYield
With lipase from Pseudomonas stutzeri PS59 In aq. phosphate buffer; isopropyl alcohol at 30℃; for 0.25h; pH=8; Enzymatic reaction;
glyceroltripalmitate
555-44-2

glyceroltripalmitate

A

2-hydroxymethyl-1,3-propanediol
4704-94-3

2-hydroxymethyl-1,3-propanediol

B

1-hexadecylcarboxylic acid
57-10-3

1-hexadecylcarboxylic acid

Conditions
ConditionsYield
With lipase from Pseudomonas stutzeri PS59 In aq. phosphate buffer; isopropyl alcohol at 30℃; for 0.25h; pH=8; Enzymatic reaction;
trioleoylglycerol
122-32-7

trioleoylglycerol

A

cis-Octadecenoic acid
112-80-1

cis-Octadecenoic acid

B

2-hydroxymethyl-1,3-propanediol
4704-94-3

2-hydroxymethyl-1,3-propanediol

Conditions
ConditionsYield
With lipase from Pseudomonas stutzeri PS59 In aq. phosphate buffer; isopropyl alcohol at 30℃; for 0.25h; pH=8; Enzymatic reaction;

4704-94-3Relevant articles and documents

Bando,Matsushima

, p. 593,594 (1973)

A high-detergent-performance, cold-adapted lipase from Pseudomonas stutzeri PS59 suitable for detergent formulation

Li, Xiao-Lu,Zhang, Wen-Hui,Wang, Ying-Dong,Dai, Yu-Jie,Zhang, Hui-Tu,Wang, Yue,Wang, Hai-Kuan,Lu, Fu-Ping

, p. 16 - 24 (2014/03/21)

A high-detergent-performance and cold-adapted lipase was purified and characterised from Pseudomonas stutzeri PS59, which was isolated from Daqing oil fields (Heilongjiang, PR China). The lipase was purified to homogeneity using ammonium sulphate precipitation, dialysis, freeze-drying, ion exchange chromatography and gel filtration chromatography. The molecular weight of the lipase was approximately 55 kDa, as measured by SDS-PAGE. The lipase showed optima activity at pH 8.5 and 20 C. The lipase activity was activated by metal ions, such as Ca2+ and Mn2+, and surfactants, such as Tween 80, Tween 20, sodium dodecyl benzene sulfonate and urea. Oxidising agents, such as H2O2 and NaClO, were found to have little effect on the activity of the lipase, and most organic solvents can enhance the activity of the lipase. The broad substrate specificity and the compatibility of the lipase in the presence of surfactants, oxidising agents, and other detergent additives clearly indicate its potential application in the laundry industry. The hydrolysis resolution of (R,S)-ethyl 2-methylbutyrate by P. stutzeri PS59 lipase was carried out with the yield of 31.2% for R-ethyl 2-methylbutyrate, the enantiomeric excess of residual substrate (ees) was 85.7%. Thus, the lipase also showed an attractive potency for application in biocatalysis.

Synthesis and antiviral activity of 9-alkoxypurines. 1. 9-(3-Hydroxypropoxy)- and 9-[3-hydroxy-2-(hydroxymethyl)propoxy]purines

Harnden,Wyatt,Boyd,Sutton

, p. 187 - 196 (2007/10/02)

Reaction of hydroxyl-protected derivatives of hydroxyalkoxyamines (3a,b,c) with either 4,6-dichloro-2,5-diformamidopyrimidine (5) or 4,6-dichloro-5-formamidopyrimidine (31) and subsequent cyclization of the resultant 6-(alkoxyamino)pyrimidines (6, 17, 32, 35) by heating with diethoxymethyl acetate afforded 9-alkoxy-6-chloropurines (7, 18, 33, 36), which were converted subsequently to 9-(3-hydroxypropoxy)- and 9-[3-hydroxy-2-(hydroxymethyl)propoxy] derivatives of guanine, 2-amino-6-chloropurine, 2-amino-6-alkoxypurines, 2-aminopurine, 2,6-diaminopurine, adenine, hypoxanthine, and 6-methoxypurine (8, 12, 13, 19-21, 23-26, 34, 37-39). Carboxylic acid esters (9-11, 14-16, 27-29) and a cyclic phosphate derivative (22) of the 9-(hydroxyalkoxy)guanines (8, 21) and 2-amino-9-(hydroxyalkoxy)purines (13, 26) were also prepared. The guanine derivatives (8, 21) showed potent and selective activity against herpes simplex virus types 1 and 2 and varicella zoster virus in cell cultures and 8 is more active than acyclovir. Although without significant antiviral activity in cell cultures, the 2-aminopurines (13, 14-16, 26-29) and 2-amino-6-alkoxypurines (12, 23-25) are well absorbed after oral administration to mice and are converted efficiently to the antiviral guanine derivatives (8, 21) in vivo.

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