4771-50-0

Basic information

• Product Name: 7-METHYLINDOLE-3-CARBOXALDEHYDE
• Synonyms: 7-METHYL-1H-INDOLE-3-CARBALDEHYDE;7-METHYLINDOLE-3-ALDEHYDE;7-METHYLINDOLE-3-CARBOXALDEHYDE;7-METHYLINDOLE-3-CARBOXYALDEHYDE;3-FORMYL-7-METHYLINDOLE;1H-Indole-3-carboxaldehyde, 7-methyl- (9CI);7-Methylindole-3-carboxaldehyde 98%;7-Methyl-3-indolecarboxaldehyde
• CAS NO: 4771-50-0
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.18
• EINECS: -0
• Product Categories: ALDEHYDE;Indoles and derivatives;Indole;Heterocyclic Compounds;Building Blocks;Heterocyclic Building Blocks;Indoles;C10-C12;Aldehydes;Building Blocks;C10;Carbonyl Compounds;Chemical Synthesis;Heterocyclic Building Blocks;Organic Building Blocks
• Mol File: 4771-50-0.mol

Chemical Properties

• Melting Point: 206-208°C
• Boiling Point: 341 °C at 760 mmHg
• Flash Point: 168 °C
• Appearance: /
• Density: 1.226 g/cm³
• Vapor Pressure: 8.31E-05mmHg at 25°C
• Refractive Index: 1.698
• Storage Temp.: −20°C
• PKA: 15.80±0.30(Predicted)
• Sensitive: Air Sensitive
• BRN: 122340
• CAS DataBase Reference: 7-METHYLINDOLE-3-CARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHYLINDOLE-3-CARBOXALDEHYDE(4771-50-0)
• EPA Substance Registry System: 7-METHYLINDOLE-3-CARBOXALDEHYDE(4771-50-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37
• WGK Germany: 3
• Hazardous Substances Data: 4771-50-0(Hazardous Substances Data)

Usage

Description

7-METHYLINDOLE-3-CARBOXALDEHYDE is an organic compound with the molecular formula C9H7NO. It is a derivative of indole and features a carboxylic aldehyde functional group. 7-METHYLINDOLE-3-CARBOXALDEHYDE is known for its potential applications in various fields due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
7-METHYLINDOLE-3-CARBOXALDEHYDE is used as a reactant for the preparation of various compounds with therapeutic potential. It serves as a building block for the synthesis of different pharmaceutical agents, including:
1. Tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles, which are potential anticancer immunomodulators. These compounds can modulate the immune system to enhance the body's response against cancer cells.
2. Antibacterial and antituberculosis agents. These agents can help in the treatment of bacterial infections, including tuberculosis, by targeting specific bacterial enzymes or pathways.
3. Antiandrogens effective against androgen receptor mutants. These compounds can be used in the treatment of prostate cancer and other androgen-dependent conditions by blocking the action of androgens on their receptors.
4. Anti-bovine viral diarrhea virus (BVDV) agents. These agents can help in the prevention and treatment of BVDV infections in cattle, which can lead to significant economic losses in the livestock industry.
5. Receptor subtype 5 antagonists. These compounds can be used in the treatment of various conditions, including neurological disorders, by blocking the action of specific receptors in the body.
6. Glucocorticoid receptor ligands. These compounds can modulate the activity of the glucocorticoid receptor, which plays a crucial role in the regulation of immune responses and stress responses.
7. Necroptosis inhibitors. These compounds can inhibit a form of programmed cell death called necroptosis, which is involved in various pathological conditions, including neurodegenerative diseases and ischemic injuries.
8. Orally efficacious small-molecule activator of the insulin receptor. These compounds can enhance the activity of the insulin receptor, which may be useful in the treatment of diabetes and other conditions related to insulin resistance.

InChI:InChI=1/C10H9NO/c1-7-3-2-4-9-8(6-12)5-11-10(7)9/h2-6,11H,1H3