487-48-9

Basic information

• Product Name: N-ACETYLSALICYLAMIDE
• Synonyms: N-ACETYLSALICYLAMIDE;TOSLAB 97261;Acetsalicylamide;Acetsallicylamide;Actylamide;Arthrisin;Benzamide, N-acetyl-2-hydroxy-;Ethrisin
• CAS NO: 487-48-9
• Molecular Formula: C₉H₉NO₃
• Molecular Weight: 179.17
• EINECS: 207-656-9
• Mol File: 487-48-9.mol
• Article Data: 9

Chemical Properties

• Melting Point: 148°
• Boiling Point: 375.4 °C at 760 mmHg
• Flash Point: 180.9 °C
• Appearance: /
• Density: 1.263 g/cm³
• Vapor Pressure: 3.6E-06mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: 2-8°C
• PKA: 7.81±0.30(Predicted)
• CAS DataBase Reference: N-ACETYLSALICYLAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-ACETYLSALICYLAMIDE(487-48-9)
• EPA Substance Registry System: N-ACETYLSALICYLAMIDE(487-48-9)

Safety Data

• Hazardous Substances Data: 487-48-9(Hazardous Substances Data)

Usage

General Description

N-Acetylsalicylamide, also known as aspirinamide, is a chemical compound derived from salicylic acid. It is a white, crystalline powder that is often used as a pain reliever and anti-inflammatory medication. N-Acetylsalicylamide is formed by reacting acetic anhydride with salicylic acid, resulting in a compound with similar medicinal properties to aspirin. It is commonly used in pharmaceuticals and research as an analgesic and antipyretic agent, and has also been studied for its potential anti-cancer and anti-inflammatory properties. Additionally, it has been reported to have potential use in enhancing the bioavailability of poorly soluble drugs. N-Acetylsalicylamide is a key compound in the field of pharmaceutical development and research.

InChI:InChI=1/C9H9NO3/c1-6(11)10-9(13)7-4-2-3-5-8(7)12/h2-5,12H,1H3,(H,10,11,13)

Upstream product

• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 65-45-2 salicylamide 
• 5663-71-8 O-acetylsalicylamide 
• 78-39-7 Triethyl orthoacetate 
• 108-88-3 toluene 
• 54789-69-4 2-methyl-4H-benzo[1,3]oxazin-4-one 
• 2757-23-5 chloro(chlorosulfanyl)methanone 
• 5538-51-2 O-acetylsalicyloyl chloride 
• 119-36-8 methyl salicylate 
• 872264-60-3 N-phenyl-N'-salicyloyl-acetamidine 
• 7732-18-5 water 
• 51051-49-1 N,O-diacetylsalicylamide 
• 7664-93-9 sulfuric acid 

Downstream Products

• 128452-44-8 2-(2-acetoxyphenyl)-4-methylthio-6-methyl-1,3,5-triazine 
• 65483-96-7 2-[1-(phenyl-2-yl)-3-methyl-1,2,4-triazol-5-yl]phenol 
• 128452-37-9 2-(2-hydroxyphenyl)-4-methylthio-6-methyl-1,3,5-triazine 
• 77718-64-0 3N-acetamido-4-hydroxybenzenesulfonyl chloride 
• 79349-23-8 2-(3-methyl-1,2,4-oxadiazol-5-yl)phenol 
• 53103-54-1 N-Acetyl-2-(2-oxo-2λ⁵-[1,3,2]dioxaphosphinan-2-yloxy)-benzamide 
• 132305-18-1 acetyl-(2-benzoyloxy-benzoyl)-amine 
• 51051-49-1 N,O-diacetylsalicylamide 
• 116704-43-9 anhydroacetylsalicylamide 

Relevant articles and documents

Compound and application of compound in preparation of medicines

The invention discloses a compound and its application in a medicine. the invention specifically provides a compound as shown in the formula (I) or a stereisomer, a geometrical isomer, a tautomer, a racemate, nitric oxide, hydrate, a solvate, a metabolite, pharmaceutically acceptable salts or a prodrug of the compound as shown in the formula (I). The invention also discloses an application of the compound in preparation of a medicine. The medicine is used in treating cancers.

Rearrangement of O-acylsalicylamides via intramolecular O-to-N transacylation: rate enhancement by an adjacent carboxylic acid group.

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