488707-59-1

Basic information

• Product Name: 3'-allyloxycarbonyl-6'-amino-5'-cyano-2'-methyl-1-(4-morpholinylmethyl)-1,3-dihydro-2-oxospiro[2H-indole-3,4'-(4'H)-pyran]
• Synonyms: 3'-allyloxycarbonyl-6'-amino-5'-cyano-2'-methyl-1-(4-morpholinylmethyl)-1,3-dihydro-2-oxospiro[2H-indole-3,4'-(4'H)-pyran]
• CAS NO: 488707-59-1
• Molecular Formula: C23H24N4O5
• Molecular Weight: 436.46046
• Mol File: 488707-59-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 729.0±60.0 °C(Predicted)
• Appearance: /
• Density: 1.38±0.1 g/cm3(Predicted)
• PKA: 4.90±0.10(Predicted)
• CAS DataBase Reference: 3'-allyloxycarbonyl-6'-amino-5'-cyano-2'-methyl-1-(4-morpholinylmethyl)-1,3-dihydro-2-oxospiro[2H-indole-3,4'-(4'H)-pyran](CAS DataBase Reference)
• NIST Chemistry Reference: 3'-allyloxycarbonyl-6'-amino-5'-cyano-2'-methyl-1-(4-morpholinylmethyl)-1,3-dihydro-2-oxospiro[2H-indole-3,4'-(4'H)-pyran](488707-59-1)
• EPA Substance Registry System: 3'-allyloxycarbonyl-6'-amino-5'-cyano-2'-methyl-1-(4-morpholinylmethyl)-1,3-dihydro-2-oxospiro[2H-indole-3,4'-(4'H)-pyran](488707-59-1)

Safety Data

• Hazardous Substances Data: 488707-59-1(Hazardous Substances Data)

Upstream product

• 1118-84-9 allyl acetoacetate 
• 6532-16-7 1-(4-morpholinylmethyl)-1H-indole-2,3-dione 
• 109-77-3 malononitrile 

Relevant articles and documents

Versatile three-component synthesis of 2'-amino-1,2-dihydrospiro[(3H)- indole-3,4'-(4'H)-pyran]-2-ones

A versatile method for the synthesis of 2'-amino-1,2-dihydrospiro[(3H)- indole-3,4'-(4'H)-pyran]-2-ones has been suggested consisting in the three-component reaction of isatins, cyanoacetic acid derivatives, and α-methylenecarbonyl compounds (β-dicarbonyl compounds, activated phenols, and OH-substituted heterocycles) in ethanol in the presence of triethylamine as a catalyst. The reaction proceeds selectively to form spiro[(3H)-indole-3,4'-(4'H)-pyrans].