4917-56-0

Basic information

• Product Name: N-(4-methylphenyl)sulfonylformamide
• Synonyms: N-(4-methylphenyl)sulfonylformamide;Benzenesulfonamide, N-formyl-4-methyl- (Related Reference)
• CAS NO: 4917-56-0
• Molecular Formula: C₈H₉NO₃S
• Molecular Weight: 199.22696
• Mol File: 4917-56-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-methylphenyl)sulfonylformamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methylphenyl)sulfonylformamide(4917-56-0)
• EPA Substance Registry System: N-(4-methylphenyl)sulfonylformamide(4917-56-0)

Safety Data

• Hazardous Substances Data: 4917-56-0(Hazardous Substances Data)

Usage

General Description

N-(4-methylphenyl)sulfonylformamide, also known as sulfonylformamide, is a chemical compound with the molecular formula C9H10N2O3S. It is a white to off-white crystalline solid that is commonly used as a reagent in organic synthesis. Sulfonylformamide is also used as a building block in the production of pharmaceuticals and agrochemicals. It has been reported to have antibacterial and antifungal activities, making it a potential candidate for use in the development of new therapeutic agents. Additionally, it is a known inhibitor of cholecystokinin, a hormone involved in digestion and appetite regulation. However, sulfonylformamide should be handled with caution due to its potential health hazards, including skin and eye irritation, as well as respiratory and gastrointestinal effects.

Upstream product

• 941-55-9 4-toluenesulfonyl azide 
• 1193-63-1 Cyclohexanone-2-carbaldehyde 
• 70-55-3 toluene-4-sulfonamide 
• 109-94-4 formic acid ethyl ester 
• 109-99-9 tetrahydrofuran 
• 29397-20-4 N¹,N¹-diethyl-N²-4-tolylsulfonylformamidine 
• 20734-18-3 diethyl 2-(hydroxymethylene)malonate 
• 22428-91-7 2-methyl-3-oxobutanal 

Downstream Products

• 312329-76-3 N-Formyl-4-methyl-N-(2-methyl-allyl)benzenesulfonamide 
• 70-55-3 toluene-4-sulfonamide 
• 169177-57-5 N-allyl-N-tosyl-2-butynamide 
• 1266335-01-6 C₁₉H₁₆FNO₃S 
• 1266335-00-5 C₂₀H₁₉NO₃S 
• 1266334-99-9 C₂₀H₁₉NO₃S 
• 1266334-98-8 C₂₂H₂₃NO₃S 
• 1266334-97-7 C₂₃H₂₅NO₃S 
• 1266335-23-2 C₁₉H₁₇⁽²⁾HFNO₃S 

Relevant articles and documents

Synthesis of diaryl ketones through oxidative cleavage of the C-C double bonds in N -Sulfonyl enamides

An oxidative cleavage of a C-C double bond is developed from the photochemical [2+2]-cycloaddition of diaryl N-tosyl enamides, aryl heteroaryl N-tosyl enamides, and N-tosyl cyclic enamides with singlet molecular oxygen, followed by a ring-opening reaction mediated by Cs2CO3 under air and sunlight without the use of photosesitizer, producing symmetrical and unsymmetrical diaryl, heterodiaryl, and cyclic ketones in good to excellent yields. Moreover, the oxidative cleavage of C-C triple bonds from 1-alkynes is demonstrated for the synthesis of symmetrical and unsymmetrical ketones from the Cu-catalyzed [3+2]-cycloaddition, Rh-catalyzed alkoxyarylation, photooxygenation, and ring-opening reaction in one-pot. Because the synthesis of the symmetrical and unsymmetrical diaryl and/or heterodiaryl ketones bearing an electron-donating group is not easy, the present method is notable.

Synthesis of Azulen-1-yl Ketones via Oxidative Cleavage of C-C Multiple Bonds in N-Sulfonyl Enamides and 1-Alkynes under Air and Natural Sunlight

A synthetic method to prepare azulen-1-yl ketones was developed via oxidative cleavage of the C-C double bond in the reaction of easily obtainable N-sulfonyl enamides with Cs2CO3 under air and natural sunlight and in the absence of a photosensitizer. Oxidative cleavage of C-C triple bonds was also demonstrated for the synthesis of azulen-1-yl ketones via a tandem Cu-catalyzed [3 + 2] cycloaddition, Rh-catalyzed arylation, photooxygenation, and ring-opening reaction in one pot under air and natural sunlight.

Stereoselective synthesis of alcohols. Part LV. Domino hydroformylation-allylboration-hydroformylation reactions to give trans-perhydropyrano[3,2-b] pyridine derivatives

N-Allyl-(E)-γ-aminoallyl boronates 8 and 18, when subjected to hydroformylation conditions, enter into a domino hydroformylation-allylboration-hydroformylation reaction cascade to generate the bicyclic N,O-heterocycles 12 and 20. On reaction of the methal