4920-77-8Relevant articles and documents
Microwave assisted synthesis of nitro phenols from the reaction of phenols with urea nitrate under acid-free conditions
Verma, Sanny,Pandita, Sangeeta,Jain, Suman L.
, p. 1320 - 1322 (2014/03/21)
Urea nitrate was found to be an inexpensive, acid-free, and safe nitrating agent that provides mononitration of phenols and substituted phenols in excellent yields with exclusive ortho-selectivity under microwave irradiation. Microwave assisted reactions reduced the reaction times substantially and enhanced the product yields from good to excellent within shorter reaction times.
Design, synthesis and anticancer activity evaluation of diazepinomicin derivatives
Yu, Yongguo,Wu, Jianbo,Lei, Fan,Chen, Lei,Wan, Weili,Hai, Li,Guan, Mei,Wu, Yong
, p. 369 - 373 (2013/07/26)
A series of diazepinomicin derivatives were synthesized and evaluated in vitro for their growth inhibitory activity against the human carcinoma cell lines. The results indicated the anticancer selectivity of this kind of compounds. Based on the results, preliminary structure-activity relationships were discussed.
Gas-phase reaction of hydroxyl radicals with m-, o- and p-cresol
Coeur-Tourneur, Cecile,Henry, Francoise,Janquin, Marie-Andree,Brutier, Laurent
, p. 553 - 562 (2008/02/10)
The gas-phase reaction of oxygenated aromatic compounds m-cresol,o-cresol. and p-cresol with hydroxyl radicals has been studied by GC-MS. Experiments have been performed in a large-volume photoreactor (8000 L) at 294 ± 2 K and atmospheric pressure. The relative kinetic method was used to determine the rate constants for these reactions, with 1,3,5-trimethylbenzene as a reference compound. The rate constants obtained are kOH(m-cresol) = (5.88 ± 0.92) × 10-11 cm3 molecule-1 s-1, kOH(o-cresol) = (4.32 ± 0.52) × 10 -11 cm3 molecule-1 s-1, and k OH(p-cresol) = (4.96 ± 0.75) × 10-11 cm 3 molecule-1 s-1. The degradation products observed and their respective molar yields were methyl-1,4-benzoquinone 12.4 ± 1.2%, 5-methyl-2-nitrophenol 1.5 ± 0.3%, and 3-methyl-2-nitrophenol 1.4 ± 0.3% from m-cresol, methyl-1,4-benzoquinone 5.6 ± 0.9%, and 6-methyl-2-nitrophenol 4.7 ± 0.8% from o-cresol. and 4-methyl-2-nitrophenol 17.2 ± 2.5% from p-cresol. This kinetic and product data are compared with the literature, and the reaction mechanisms are discussed. Our results are in accordance with the previous studies (Atkinson, J Phys Chem Ref Data 1989, Monograph (1), 1-246; Atkinson and Aschmann. Int J Chem Kinet 1990, 22, 59-67; Atkinson et al., Environ Sci Technol 1992, 26, 1397-1403; Atkinson et al., J Phys Chem 1978, 82, 2759-2805; Olariu et al., Atoms Environ 2002, 36, 3685-3697; Semadeni et al., Int J Chem Kinet 1995, 27, 287-304) and confirm the methyl-1,4-benzoquinone yields determined by a different experimental technique (long-path Fourier transform infrared FT-IR (Olariu et al., 2002)).
