500357-36-8

Basic information

• Product Name: (7-bromo-9H-fluoren-2-yl)-urea
• Synonyms: (7-bromo-9H-fluoren-2-yl)-urea
• CAS NO: 500357-36-8
• Molecular Weight: 303.158
• Mol File: 500357-36-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (7-bromo-9H-fluoren-2-yl)-urea(CAS DataBase Reference)
• NIST Chemistry Reference: (7-bromo-9H-fluoren-2-yl)-urea(500357-36-8)
• EPA Substance Registry System: (7-bromo-9H-fluoren-2-yl)-urea(500357-36-8)

Safety Data

• Hazardous Substances Data: 500357-36-8(Hazardous Substances Data)

Upstream product

• 6638-60-4 2-amino-7-bromofluorene 
• 530-62-1 1,1'-carbonyldiimidazole 

Relevant articles and documents

Synthesis, activity, and pharmacokinetic properties of a series of conformationally-restricted thiourea analogs as novel hepatitis C virus inhibitors

A series of novel conformationally-restricted thiourea analogs were designed, synthesized, and evaluated for their anti-HCV activity. Herein we report the synthesis, structure-activity relationships (SARs), and pharmacokinetic properties of this new class of thiourea compounds that showed potent inhibitory activities against HCV in the cell-based subgenomic HCV replicon assay. Among compounds tested, the fluorene compound 4b was found to possess the most potent activity (EC50 = 0.3 μM), lower cytotoxicity (CC50 > 50 μM), and significantly better pharmacokinetic properties compared to its corresponding fluorenone compound 4c.