5033-23-8

Basic information

• Product Name: 1-(Phenylsulfonyl)piperidine, 97%
• Synonyms: 1-(Phenylsulfonyl)piperidine, 97%
• CAS NO: 5033-23-8
• Molecular Formula: C₁₁H₁₅NO₂S
• Molecular Weight: 225.3073
• Mol File: 5033-23-8.mol
• Article Data: 38

Chemical Properties

• Melting Point: 91.3-97 °C
• Boiling Point: 356.5°Cat760mmHg
• Flash Point: 169.4°C
• Appearance: /
• Density: 1.219g/cm³
• Vapor Pressure: 2.91E-05mmHg at 25°C
• Refractive Index: 1.569
• PKA: -4.73±0.20(Predicted)
• CAS DataBase Reference: 1-(Phenylsulfonyl)piperidine, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(Phenylsulfonyl)piperidine, 97%(5033-23-8)
• EPA Substance Registry System: 1-(Phenylsulfonyl)piperidine, 97%(5033-23-8)

Safety Data

• Hazardous Substances Data: 5033-23-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 24, p. 205, 1994 DOI: 10.1080/00397919408013820

InChI:InChI=1/C11H15NO2S/c13-15(14,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1,3-4,7-8H,2,5-6,9-10H2

Upstream product

• 110-89-4 piperidine 
• 98-09-9 benzenesulfonyl chloride 
• 873-55-2 sodium benzenesulfonate 
• 108-98-5 thiophenol 
• 5535-48-8 PVS 
• 2591-86-8 N-Formylpiperidine 
• 369-57-3 benzenediazonium tetrafluoroborate 
• 71-43-2 benzene 
• 591-50-4 iodobenzene 
• 66003-76-7 Diphenyliodonium triflate 
• 80-17-1 benzenesufonyl hydrazide 
• 5542-49-4 piperidin-1-yl benzoate 
• 16978-76-0 1-phenyl-2-(piperidin-1-yl)diazene 
• 62-53-3 aniline 

Downstream Products

• 110-89-4 piperidine 
• 98-09-9 benzenesulfonyl chloride 
• 46855-40-7 5-(benzenesulfonyl-methyl-amino)-valeric acid 
• 133932-29-3 5-benzenesulfonylamino-valeric acid 
• 106762-74-7 diphenyl<2-(piperidinosulfonyl)phenyl>methanol 

Relevant articles and documents

An efficient protocol for the selective reduction of benzenesulfonyllactam to benzenesulfonyl cyclic amine

The selective reduction of N-benzenesulfonylpiperidin-2-one to N-benzenesulfonylpiperidine was accomplished through the use of NaBH4 with either ZrCl4 or SnCl4 and by silane-mediated two-step reductions.

Synthesis of Sulfones and Sulfonyl Derivatives using Sodium (tert-butyldimethylsilyl)oxymethanesulfinate

The present invention relates to a method for manufacturing a sulfone and sulfonyl derivative compound using sodium (tert-butyldimethylsilyl)oxymethanesulfinate, which is a novel organic sulfin salt, wherein the novel organic sulfin salt has good stability, environmental friendliness and economy, and is easy to handle, and thus significantly reduces the amount of transition metal catalysts and the amount of organic sulfin salts used when introducing aryl or alkenyl. Also, alkylation, arylation, amination, and fluorination are all possible during secondary functionalization. Therefore, the present invention can be usefully used in preparation and mass production of various kinds of sulfones and derivatives thereof including asymmetric sulfone derivatives.

Efficient and Practical Synthesis of Sulfonamides Utilizing SO2 Gas Generated on Demand

A simple and practical protocol was developed for the synthesis of sulfonamides by reacting organometallic reagents with SO2 gas generated on demand. SO2 was generated from readily available reagents safely in a highly contained and controlled fashion. The protocol allows the synthesis of sulfonamides without using either atom-inefficient SO2 surrogates or a SO2 cylinder that requires stringent storage regulations in the laboratory. The protocol was successfully applied to the synthesis of sildenafil.