507-02-8 Usage
Description
Acetyl iodide, also known as ethanoic acid iodide, is a colorless, fuming liquid with a pungent odor. It is soluble in benzene and ether, and is known for its corrosive properties, as it can react with metals and skin. Acetyl iodide is toxic, and its vapors are irritating to the eyes and mucous membranes, potentially causing pulmonary edema. It turns brown upon exposure to air due to an exothermic reaction with moisture, producing hydrogen iodide, a strong irritant. Acetyl iodide decomposes in water, yielding acidic products, and its reaction with water can generate heat, increasing the concentration of fumes in the air. In the event of a fire, acetyl iodide can produce irritating, corrosive, and/or toxic gases, and its run-off may be corrosive and/or toxic, causing environmental pollution.
Uses
1. Used in Organic Synthesis:
Acetyl iodide is used as a reagent in organic synthesis for various applications, including the acetylation of alcohols, amines, and other organic compounds. Its high reactivity and selectivity make it a valuable tool in the synthesis of complex organic molecules.
2. Used in Analytical Chemistry:
In analytical chemistry, acetyl iodide is employed as a derivatizing agent for the detection and quantification of certain functional groups, such as hydroxyl and amine groups, in various samples. Its ability to react with these groups allows for the formation of derivatives that can be more easily analyzed and identified.
3. Used in Pharmaceutical Industry:
Acetyl iodide is utilized in the pharmaceutical industry for the synthesis of various drugs and drug intermediates. Its unique reactivity and properties enable the production of specific compounds that may have therapeutic applications.
4. Used in Material Science:
In material science, acetyl iodide can be used for the modification of polymers and other materials. Its ability to react with certain functional groups allows for the creation of new materials with altered properties, such as improved stability or reactivity.
5. Used in Research and Development:
Acetyl iodide is also used in research and development settings, where its unique properties and reactivity are harnessed to explore new chemical reactions and develop novel compounds for various applications.
Air & Water Reactions
Turns brown on exposure to air as ACETYL IODIDE reacts exothermically with moisture in the air to give hydrogen Iodide (hydroiodic acid), a strong irritant. Decomposes in water to give acidic products.
Reactivity Profile
ACETYL IODIDE decomposes exothermically in water or alcohol. Reacts vigorously and exothermically with bases. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Health Hazard
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
Safety Profile
A toxic, corrosive material. Reacts with water or steam to produce toxic and corrosive fumes. Dangerous to use. When heated to decomposition it emits toxic fumes of I-. See also IODIDES.
Purification Methods
Purify it by fractional distillation. [Beilstein 2 H 174, 2 I 80, 2 II 177, 2 III 393, 2 IV 399.] TOXIC and LACHRYMATORY.
Check Digit Verification of cas no
The CAS Registry Mumber 507-02-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,0 and 7 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 507-02:
(5*5)+(4*0)+(3*7)+(2*0)+(1*2)=48
48 % 10 = 8
So 507-02-8 is a valid CAS Registry Number.
InChI:InChI=1/C2H3IO/c1-2(3)4/h1H3
507-02-8Relevant articles and documents
Moloney,Krisher
, p. 3277,3280 (1966)
Ketyl radical reactivity via atom transfer catalysis
Wang, Lu,Lear, Jeremy M.,Rafferty, Sean M.,Fosu, Stacy C.,Nagib, David A.
, p. 225 - 229 (2018)
Single-electron reduction of a carbonyl to a ketyl enables access to a polarity-reversed platform of reactivity for this cornerstone functional group. However, the synthetic utility of the ketyl radical is hindered by the strong reductants necessary for its generation, which also limit its reactivity to net reductive mechanisms.We report a strategy for net redox-neutral generation and reaction of ketyl radicals.The in situ conversion of aldehydes to a-acetoxy iodides lowers their reduction potential by more than 1 volt, allowing for milder access to the corresponding ketyl radicals and an oxidative termination event. Upon subjecting these iodides to a dimanganese decacarbonyl precatalyst and visible light irradiation, an atom transfer radical addition (ATRA) mechanism affords a broad scope of vinyl iodide products with high Z-selectivity.
Mapping-Out Catalytic Processes in a Metal–Organic Framework with Single-Crystal X-ray Crystallography
Burgun, Alexandre,Coghlan, Campbell J.,Huang, David M.,Chen, Wenqian,Horike, Satoshi,Kitagawa, Susumu,Alvino, Jason F.,Metha, Gregory F.,Sumby, Christopher J.,Doonan, Christian J.
supporting information, p. 8412 - 8416 (2017/07/11)
Single-crystal X-ray crystallography is employed to characterize the reaction species of a full catalytic carbonylation cycle within a MnII-based metal–organic framework (MOF) material. The structural insights explain why the Rh metalated MOF is catalytically competent toward the carbonylation of MeBr but only affords stoichiometric turn-over in the case of MeI. This work highlights the capability of MOFs to act as platform materials for studying single-site catalysis in heterogeneous systems.