5070-13-3 Usage
Description
Bis(4-nitrophenyl) carbonate is a white to pale yellow or beige powder that serves as a versatile reagent in the field of organic chemistry. It is particularly useful for the preparation of symmetrical and unsymmetrical urea and 4-nitrophenyl esters of N-protected amino acids, as well as for the synthesis of carbamate linked cytosines.
Uses
Used in Organic Chemistry:
Bis(4-nitrophenyl) carbonate is used as a reagent for the preparation of symmetrical and unsymmetrical urea and 4-nitrophenyl esters of N-protected amino acids. It facilitates the formation of these compounds, which are essential in various chemical and pharmaceutical applications.
Used as a Peptide Coupling Reagent:
In the field of peptide synthesis, Bis(4-nitrophenyl) carbonate acts as a peptide coupling reagent. This role is crucial for the formation of peptide bonds, which are the building blocks of proteins and essential for various biological functions.
Used in the Preparation of Carbamate Linked Cytosines:
Bis(4-nitrophenyl) carbonate also finds application as a reagent for the preparation of carbamate linked cytosines. These modified nucleosides play a significant role in the study of nucleic acid chemistry and can have implications in the development of new therapeutic strategies for various diseases.
Purification Methods
Dissolve the carbonate in CHCl3, wash it with 2N NaOH (3 x) and once with conc HCl, dry (Na2SO4), evaporate and crystallise the residue from toluene (authors say prisms from 15 volumes of *benzene). [Glatthard & Matter Helv Chim Acta 46 795 1963, Beilstein 6 III 820.]
Check Digit Verification of cas no
The CAS Registry Mumber 5070-13-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,0,7 and 0 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 5070-13:
(6*5)+(5*0)+(4*7)+(3*0)+(2*1)+(1*3)=63
63 % 10 = 3
So 5070-13-3 is a valid CAS Registry Number.
InChI:InChI=1/C13H8N2O7/c16-13(21-11-5-1-9(2-6-11)14(17)18)22-12-7-3-10(4-8-12)15(19)20/h1-8H
5070-13-3Relevant articles and documents
Fife,Mc Mahon
, p. 7481 (1969)
CARBONATE DERIVATIVE PRODUCTION METHOD
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Paragraph 0135-0136; 0143-0144, (2020/04/09)
The objective of the present invention is to provide a method for producing a carbonate derivative in a safe and efficient manner. The method for producing a carbonate derivative according to the present invention is characterized in comprising irradiating light on a composition containing a C1-4 halogenated hydrocarbon having one or more kinds of halogen atoms selected from the group consisting of a chlorine atom, a bromine atom and an iodine atom, a nucleophilic functional group-containing compound and the specific base in the presence of oxygen.
Synthesis of organic carbonates with alkyl/aryl 4,5-dichloro-6-oxopyridazine-1(6H)-carboxylates and ROH/AlCl3under ambient condition
Sung, Gi Hyeon,Bo, Ram Kim,Ryu, Ki Eun,Kim, Jeum-Jong,Yoon, Yong-Jin
, p. 2758 - 2764 (2015/04/22)
We demonstrated the synthesis of organic carbonates using alkyl/aryl 4,5-dichloro-6-oxopyridazine-1(6H)-carboxylates and alcohol in the presence of aluminum chloride. Alkyl/aryl 4,5-dichloro-6-oxopyridazine-1(6H)-carboxylates were reacted with alcohol in the presence of AlCl3 in toluene at room temperature to afford the corresponding unsymmetric and symmetric organic carbonates in good to excellent yields. These are efficient and convenient processes. Alkyl/aryl 4,5-dichloro-6-oxopyridazine-1(6H)-carboxylates are solid, stable and non-toxic CO2/CO2R(Ar) source. It is noteworthy that the reaction is carry out under an ambient and acidic conditions, the easy-to prepare and readily available starting materials and the quantitative isolation of reusable 4,5-dichloropyridazin-3(2H)-one.