5105-79-3

Basic information

• Product Name: Butanoic acid, 4-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester
• CAS NO: 5105-79-3
• Molecular Formula: C16H23NO4
• Molecular Weight: 293.363
• Mol File: 5105-79-3.mol
• Article Data: 23

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 4-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 4-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester(5105-79-3)
• EPA Substance Registry System: Butanoic acid, 4-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester(5105-79-3)

Safety Data

• Hazardous Substances Data: 5105-79-3(Hazardous Substances Data)

Upstream product

• 5105-78-2 4-(benzyloxycarbonylamino)butyric acid 
• 75-65-0 tert-butyl alcohol 
• 104-57-4 benzyl formate 
• 501-53-1 benzyl chloroformate 
• 507-19-7 t-butyl bromide 
• 36805-97-7 N,N-dimethylformamide di-tert-butyl acetal 
• 115-11-7 isobutene 

Downstream Products

• 1296665-15-0 ethyl 5-(2-(benzyloxy)ethyl)-3-(3-(tert-butoxycarbonyl)propyl)-6-methyl-3H-pyrimidin-4-one-2-carboxylate 
• 5105-84-0 N^α--N^γ-<3-tert-butoxycarbonylpropyl>-L-glutaminyl-L-phenylalanin-tert-butylester 
• 5105-80-6 N--γ-L-glutaminyl-γ-Aminobuttersaeure-tert-butylester 
• 5105-92-0 N^α-Benzyloxycarbonyl-N^γ-(3-tert.-butoxycarbonyl-propyl)-L-glutaminsaeure-benzylester 
• 5105-94-2 N-(Benzyloxycarbonyl-α-L-glutamyl)-γ-aminobuttersaeure-tert.-butylester 
• 5105-82-8 N^α--N^γ-<3-tert-butoxycarbonyl-propyl>-L-glutaminyl-L-leucin-tert-butylester 
• 5105-81-7 N^α--N^γ-<3-tert-butoxycarbonyl-propyl>-L-glutaminyl-glycin-tert-butylester 
• 100702-80-5 tert-butyl 4-<(benzyoxycarbonyl)amino>-2-(hydroxymethyl)-2-(phenylseleno)butanoate 
• 100702-81-6 tert-butyl (E)-4-<(benzyoxycarbonyl)amino>-2-(hydroxymethyl)-2-butenoate 
• 100702-82-7 tert-butyl (Z)-4-<(benzyoxycarbonyl)amino>-2-(chloromethyl)-2-butenoate 
• 100702-83-8 tert-butyl (Z)-4-<(benzyoxycarbonyl)amino>-2-(fluoromethyl)-2-butenoate 
• 120686-44-4 4-[(E)-2-(Benzyloxycarbamoyl-methyl)-3-phenyl-acryloylamino]-butyric acid tert-butyl ester 
• 120686-27-3 (E)-3-(3-tert-Butoxycarbonyl-propylcarbamoyl)-4-phenyl-but-3-enoic acid ethyl ester 
• 120686-35-3 (E)-3-(3-tert-Butoxycarbonyl-propylcarbamoyl)-4-phenyl-but-3-enoic acid 

Relevant articles and documents

CONJUGATES OF A CELL-BINDING MOLECULE WITH CAMPTOTHECIN ANALOGS

Provided are conjugates of camptothecin analogs with a cell-binding molecule of formula (I), wherein R1, R2, R3, R4, R5, X, L, n, m, T and ----- are defined herein. It also provides methods of making the conjugates of camptothecin analogs to a cell-binding agent, as well as methods of using the conjugates in targeted treatment of cancer, infection, and immunological disorders.

CROSS-LINKED PYRROLOBENZODIAZEPINE DIMER (PBD) DERIVATIVE AND ITS CONJUGATES

A novel cross-linked cytotoxic agents, pyrrolobenzo-diazepine dimer (PBD) derivatives, and their conjugates to a cell-binding molecule, a method for preparation of the conjugates and the therapeutic use of the conjugates.

A CONJUGATE OF A TUBULYSIN ANALOG WITH BRANCHED LINKERS

The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.