51449-77-5

Basic information

• Product Name: 5-(2-HYDROXYPHENYL)-1H-TETRAZOLE
• Synonyms: 5-(2-HYDROXYPHENYL)-1H-TETRAZOLE;2-(1H-Tetrazol-5-yl)phenol, 97%;5-(o-Hydroxyphenyl)tetrazole
• CAS NO: 51449-77-5
• Molecular Formula: C₇H₆N₄O
• Molecular Weight: 162.14874
• Mol File: 51449-77-5.mol
• Article Data: 74

Chemical Properties

• Melting Point: 230°C
• Boiling Point: 391.8 °C at 760 mmHg
• Flash Point: 190.8 °C
• Appearance: /
• Density: 1.458 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.668
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.02±0.10(Predicted)
• CAS DataBase Reference: 5-(2-HYDROXYPHENYL)-1H-TETRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-HYDROXYPHENYL)-1H-TETRAZOLE(51449-77-5)
• EPA Substance Registry System: 5-(2-HYDROXYPHENYL)-1H-TETRAZOLE(51449-77-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 51449-77-5(Hazardous Substances Data)

Usage

General Description

5-(2-HYDROXYPHENYL)-1H-TETRAZOLE is a chemical compound with the molecular formula C7H6N4O. It is a type of tetrazole derivative that contains a hydroxyphenyl group. 5-(2-HYDROXYPHENYL)-1H-TETRAZOLE is commonly utilized in organic chemistry and pharmaceutical research, particularly for its potential as a ligand in metal coordination chemistry and as a building block for drug design. It has also been studied for its potential biological activities, including anti-inflammatory and anti-cancer properties. Additionally, 5-(2-HYDROXYPHENYL)-1H-TETRAZOLE may also have potential applications in material science and as a component in the synthesis of complex organic molecules.

InChI:InChI=1/C7H6N4O/c12-6-4-2-1-3-5(6)7-8-10-11-9-7/h1-4,12H,(H,8,9,10,11)

Upstream product

• 611-20-1 salicylonitrile 
• 96-10-6 diethyl aluminiumcholoride 
• 90-02-8 salicylaldehyde 
• 533-58-4 2-Iodophenol 
• 95-56-7 2-hydroxybromobenzene 
• 68314-54-5 1-bromo-2-(methoxymethoxy)benzene 
• 29577-53-5 2-Methoxy-benzaldehyde oxime 
• 94-67-7 salicylaldehyde-oxime 

Downstream Products

• 76310-72-0 <(4-hydroxy-3-1H-tetrazol-5-yl)phenyl>ethanone 
• 611-20-1 salicylonitrile 
• 539-80-0 Tropone 
• 95-48-7 ortho-cresol 
• 76310-71-9 2-bromo-1-<4-hydroxy-3-(1H-tetrazol-5-yl)phenyl>ethanone 
• 473731-78-1 C₇H₅N₅O₃ 
• 172352-72-6 tetrazolylphenyl pivalate 

Relevant articles and documents

Synthesis and characterization of magnetic Fe3O4@Creatinine@Zr nanoparticles as novel catalyst for the synthesis of 5-substituted 1H-tetrazoles in water and the selective oxidation of sulfides with classical and ultrasonic methods

Tetrazoles and sulfoxide compounds have a wide range of applications in industries and are of great expectation to be environmentally friendly and cost-effective. This paper reports the introduction of zirconium supported on Fe3O4 na

Catalytic conversion of 2,4,5-trisubstituted imidazole and 5-substituted 1H-tetrazole derivatives using a new series of half-sandwich (η6-p-cymene)Ruthenium(II) complexes with thiophene-2-carboxylic acid hydrazone ligands

A new series of half-sandwich (η6-p-cymene) ruthenium(II) complexes with thiophene-2-carboxylic acid hydrazide derivatives [Ru(η6-p-cymene)(Cl)(L)] [L = N'-(naphthalen-1-ylmethylene)thiophene-2-carbohydrazide (L1), N'-(anthracen-9-ylmethylene)thiophene-2-carbohydrazide (L2) and N'-(pyren-1-ylmethylene)thiophene-2-carbohydrazide (L3)] were synthesized. The ligand precursors and their Ru(II) complexes (1–3) were structurally characterized by spectral (IR, UV–Vis, NMR and mass spectrometry) and elemental analysis. The molecular structures of the ruthenium(II) complexes 1–3 were determined by single-crystal X-ray diffraction. All complexes were used as catalysts for the one-pot three-component syntheses of 2,4,5-trisubstitued imidazole and 5-substituted 1H-tetrazole derivatives. The catalytic studies optimized parameters as solvent, temperature and catalyst. The catalysts revealed very active for a broad range of aromatic aldehydes presenting either electron attractor or electron donor substituents and, although less active, moderate to high activities were observed for alkyl aldehydes.

Magnetization of biochar nanoparticles as a novel support for fabrication of organo nickel as a selective, reusable and magnetic nanocatalyst in organic reactions

Catalyst species are an important class of materials in chemistry, industry, medicine and biotechnology. Also, waste recycling is an important process in green chemistry and economic efficiency. Therefore, in order to recycle waste, biochar nanoparticles were prepared from chicken manure. Then, the biochar nanoparticles were magnetized under a green and environmentally friendly method. Finally, the surface of the magnetic biochar nanoparticles was modified and further they were applied as a novel support for fabrication of nickel as a homoselective and reusable catalyst in organic reactions. The structure of this organic-inorganic catalyst has been characterized by N2adsorption-desorption isotherms, and the SEM, EDS, WDX, XRD, TGA, AAS, FT-IR and VSM techniques. This magnetically recyclable catalyst was used in the homoselective synthesis of tetrazole and pyranopyrazole derivatives. This catalyst can be reused several times without significant loss of its catalytic efficiency. The heterogeneity and stability of this nanocatalyst were studied by hot filtration and the AAS technique. Also, the reused catalyst was characterized by the SEM, EDS, AAS and BET techniques.