515-83-3

Basic information

• Product Name: 2,2,2-TRICHLORO-1-ETHOXYETHANOL
• Synonyms: 1-ethoxy-2,2,2-trichloro-ethano;1-ethoxy-2,2,2-trichloroethanol;2,2,2-trichloro-1-ethoxy-ethano;chloral,ethylhemiacetal;Chloralacetal;chloral-acetal;chloralalkoholat;chloralethylalcoholate
• CAS NO: 515-83-3
• Molecular Formula: C₄H₇Cl₃O₂
• Molecular Weight: 193.46
• EINECS: 208-211-1
• Mol File: 515-83-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 47 °C
• Boiling Point: 116 °C
• Flash Point: 116°C
• Appearance: White to light yellow/Crystalline Powder, Crystals, Needles or Low Melting Mass
• Density: 1,143 g/cm3
• Vapor Pressure: 9.31mmHg at 25°C
• Refractive Index: 1.488
• PKA: 10.84±0.20(Predicted)
• Water Solubility: Slightly soluble in Water.
• Sensitive: Hygroscopic
• Merck: 14,2069
• BRN: 1209355
• CAS DataBase Reference: 2,2,2-TRICHLORO-1-ETHOXYETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-TRICHLORO-1-ETHOXYETHANOL(515-83-3)
• EPA Substance Registry System: 2,2,2-TRICHLORO-1-ETHOXYETHANOL(515-83-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 23-36/37
• RTECS: KM4725000
• TSCA: Yes
• Hazardous Substances Data: 515-83-3(Hazardous Substances Data)

Usage

Description

2,2,2-Trichloro-1-ethoxyethanol is a white to light yellow crystalline powder that is primarily utilized in the pharmaceutical and chemical industries. It is a versatile compound with a range of applications due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
2,2,2-Trichloro-1-ethoxyethanol is used as an intermediate in the synthesis of various pharmaceutical compounds. Its chemical structure allows for the development of new drugs with potential therapeutic benefits.
Used in Chemical Industry:
2,2,2-Trichloro-1-ethoxyethanol is used as an intermediate in the production of fluorine plastics. Its unique properties contribute to the development of advanced materials with specific characteristics, such as increased durability and resistance to various environmental factors.

Safety Profile

Moderately toxic by ingestion.When heated to decomposition it emits toxic fumes ofClí.

InChI:InChI=1/C4H7Cl3O2/c1-2-9-3(8)4(5,6)7/h3,8H,2H2,1H3/t3-/m1/s1

Upstream product

• 64-17-5 ethanol 
• 75-87-6 chloral 
• 7782-50-5 chlorine 
• 621-62-5 chloroacetaldehyde diethyl acetal 
• 60-29-7 diethyl ether 
• 554-21-2 chloralide 
• 18271-85-7 chloral butylhemiacetal 
• 122-51-0 orthoformic acid triethyl ester 
• 23639-53-4 chloral propylhemiacetal 
• 302-17-0 chloral hydrate 
• 555-75-9 aluminum ethoxide 
• 75-07-0 acetaldehyde 
• 24298-56-4 2,2-diacetoxy-1,1,1-trichloro-ethane 
• 78-10-4 tetraethoxy orthosilicate 

Downstream Products

• 64-18-6 formic acid 
• 67-66-3 chloroform 
• 513-96-2 3,3,3-trichloro-2-hydroxy-propionitrile 
• 475-26-3 1,1'-(2,2,2-trichloroethylidene)bis(p-fluorobenzene) 
• 64-17-5 ethanol 
• 75-87-6 chloral 
• 18261-09-1 acetic acid-(1-ethoxy-2,2,2-trichloro-ethyl ester) 
• 24298-56-4 2,2-diacetoxy-1,1,1-trichloro-ethane 
• 141-78-6 ethyl acetate 
• 74-87-3 methylene chloride 
• 83158-65-0 2-ethoxy-1,1,1-trichloro-2-methoxy-ethane 
• 540-67-0 ethyl methyl ether 
• 540-82-9 ethyl sulfate 
• 101080-38-0 N-(2-bromophenyl)-2-isonitrosoacetanilide 

Relevant articles and documents

Interactive n→σ* delocalizations that control an aqueous organic equilibrium

Hydrated acetaldehydes were condensed in D2O with substituted alcohols and thiols to determine ΔG of hemiacetalization by 1H NMR. Specific n→σ* delocalizalions in the alkoxy/alkylthio functionality of the product interact to influence n→σ* delocalization in the hemiacetal functionality. Delocalization in the latter functionality controls ΔG.

Study of the hemiacetals and hemimercaptals of chloral

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