51832-31-6

Basic information

• Product Name: dimethyl 4-aminophthalate
• Synonyms: dimethyl 4-aminophthalate;1,2-Benzenedicarboxylic acid, 4-amino-, dimethyl ester;Ai3-14780;Einecs 257-460-2;1,2-DiMethyl 4-aMinophthalate
• CAS NO: 51832-31-6
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209.19864
• EINECS: 257-460-2
• Mol File: 51832-31-6.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 347.8°C at 760 mmHg
• Flash Point: 174.5°C
• Appearance: /
• Density: 1.248g/cm³
• Vapor Pressure: 5.25E-05mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: 2-8°C(protect from light)
• PKA: 1.32±0.10(Predicted)
• CAS DataBase Reference: dimethyl 4-aminophthalate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 4-aminophthalate(51832-31-6)
• EPA Substance Registry System: dimethyl 4-aminophthalate(51832-31-6)

Safety Data

• Hazardous Substances Data: 51832-31-6(Hazardous Substances Data)

Usage

Description

Dimethyl 4-aminophthalate is a chemical compound that features a 4-aminophthalate group and two methyl groups. It is a white to off-white powder with a molecular formula of C10H11NO4 and a molecular weight of 209.20 g/mol. dimethyl 4-aminophthalate is recognized for its role as an intermediate in the production of various chemical products and for its applications in organic chemistry.

Uses

Used in Dye and Pigment Production:
Dimethyl 4-aminophthalate is used as an intermediate for the production of dyes and pigments, contributing to the coloration and stability of these substances in various applications.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, dimethyl 4-aminophthalate is utilized as an intermediate in the synthesis of various pharmaceuticals, playing a crucial role in the development of new medications.
Used in Organic Chemistry:
Dimethyl 4-aminophthalate serves as a versatile building block in organic chemistry, with its chemical structure and properties making it valuable for the preparation of polymers, resins, and other specialty chemicals.
Used in Industrial Applications:
dimethyl 4-aminophthalate is also important in various industrial applications, where it is used to create a range of products that require its specific chemical properties.

InChI:InChI=1/C10H11NO4/c1-14-9(12)7-4-3-6(11)5-8(7)10(13)15-2/h3-5H,11H2,1-2H3

Upstream product

• 67-56-1 methanol 
• 610-27-5 4-nitrophthalic acid 
• 75-75-2 methanesulfonic acid 
• 7647-01-0 hydrogenchloride 
• 610-22-0 dimethyl 4-nitrophthalate 

Downstream Products

• 20871-09-4 4-Amino-N-(p-methoxyphenyl)phthalimide 
• 100724-63-8 4-(2-cyano-acetylamino)-phthalic acid dimethyl ester 
• 1260403-53-9 dimethyl 4-(dibenzylamino)benzene-1,2-dicarboxylate 
• 957130-49-3 (R)-5-amino-1,3-dihydrospiro[indene-2,3’-pyrrolo[2,3-b]pyridin]-2’(1’H)-one 
• 957118-49-9 [3H]-MK 3207 
• 1260403-54-0 [4-(dibenzylamino)-2-(hydroxymethyl)phenyl]methanol 
• 1260403-57-3 (R)-1’-(tert-butyl)-5-(dibenzylamino)-1,3-dihydrospiro[indene-2,3’-pyrrolo[2,3-b]pyridin]-2’(1’H)-one 
• 1260403-55-1 [2-(chloromethyl)-4-(dibenzylamino)phenyl]methanol hydro chloride 

Relevant articles and documents

Stereoselective Synthesis of New (2 S,3 R)-3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid Analogues Utilizing a C(sp3)-H Activation Strategy and Structure-Activity Relationship Studies at the Ionotropic Glutamate Receptors

Competitive antagonists for ionotropic glutamate receptors (iGluRs) are highly valuable tool compounds for studying health and disease states in the central nervous system. However, only few subtype selective tool compounds are available and the discovery of antagonists with novel iGluR subtype selectivity profiles remains a profound challenge. In this paper, we report an elaborate structure-activity relationship (SAR) study of the parental scaffold 2,3-trans-3-carboxy-3-phenyl-proline by the synthesis of 40 new analogues. Three synthetic strategies were employed with two new strategies of which one being a highly efficient and fully enantioselective strategy based on C(sp3)-H activation methodology. The SAR study led to the conclusion that selectivity for the NMDA receptors was a general trend when adding substituents in the 5′-position. Selective NMDA receptor antagonists were obtained with high potency (IC50 values as low as 200 nM) and 3-34-fold preference for GluN1/GluN2A over GluN1/GluN2B-D NMDA receptors.

HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS

Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: wherein R1, R2, R4, R5, R6, R7, R8, R9, R10,Z, X1, X2, X3, L2, HET, n and q are as defined herein. The compounds are inhibitors of adrenomedullin receptor subtype 2 (AM2). Also disclosed are the compounds for use in the treatment of diseases modulated AM2, including proliferative diseases such as cancer; pharmaceutical compositions comprising the compounds; methods for preparing the compounds; and intermediates useful in the preparation of the compounds.

COMPOUNDS

Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: (I) wherein R1, R2, R3, R4, R5, R6, R8, R9, X, X1, X2, X3, L1 and n are as defined herein. The compounds are inhibitors of adrenomedullin receptor subtype 2 (AM2). Also disclosed are the compounds for use in the treatment of diseases modulated AM2, including proliferative diseases such as cancer; pharmaceutical compositions comprising the compounds; methods for preparing the compounds;and intermediates useful in the preparation of the compounds.