52107-21-8 Usage
Description
Cyclopropyl chloroformate, with the chemical formula C4H5ClO2, is a colorless, volatile liquid that serves as a reagent in organic synthesis for the introduction of the cyclopropyl group. It is also utilized in the preparation of β-lactams and other organic chemicals. Recognized as a hazardous chemical, it can cause skin and eye irritation upon contact and is toxic when inhaled or ingested, necessitating proper safety precautions during handling.
Uses
Used in Organic Synthesis:
Cyclopropyl chloroformate is used as a reagent for the introduction of the cyclopropyl group in organic synthesis. Its ability to form stable carboxylic acid derivatives makes it a valuable component in the creation of various organic compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, cyclopropyl chloroformate is used as a key intermediate in the synthesis of β-lactams, a class of antibiotics that includes penicillins and cephalosporins. Its role in the production of these essential drugs highlights its importance in medical applications.
Used in Chemical Research:
Cyclopropyl chloroformate is also utilized in chemical research for studying the properties and reactions of cyclopropyl-containing compounds. Its unique reactivity and stability contribute to the advancement of knowledge in organic chemistry and the development of new chemical processes and products.
Check Digit Verification of cas no
The CAS Registry Mumber 52107-21-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,1,0 and 7 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 52107-21:
(7*5)+(6*2)+(5*1)+(4*0)+(3*7)+(2*2)+(1*1)=78
78 % 10 = 8
So 52107-21-8 is a valid CAS Registry Number.
52107-21-8Relevant articles and documents
Synthesis and Optimization of Kv7 (KCNQ) Potassium Channel Agonists: The Role of Fluorines in Potency and Selectivity
Liu, Ruiting,Tzounopoulos, Thanos,Wipf, Peter
supporting information, p. 929 - 935 (2019/06/13)
Based on the potent Kv7 agonist RL-81, we prepared new lead structures with greatly improved selectivity for Kv7.2/Kv7.3 over related potassium channels, i.e., Kv7.3/Kv7.5, Kv7.4, and Kv7.4/7.5. RL-36 and RL-12 maintain an agonist EC2x of ca. 1 μM on Kv7.2/Kv7.3 in a high-throughput assay on an automated electrophysiology platform in HEK293 cells but lack activity on Kv7.3/Kv7.5, Kv7.4, and Kv7.4/7.5, resulting in a selectivity index SI > 10. RL-56 is remarkably potent, EC2x 0.11 ± 0.02 μM, and still shows an SI = 2.5. We also identified analogues with significant selectivity for Kv7.4/Kv7.5 over Kv7.2/Kv7.3. The extensive use of fluorine in iterative core structure modifications highlights the versatility of these substituents, including F, CF3, and SF5, to span orders of magnitude of potency and selectivity in medicinal chemistry lead optimizations.
CYSTEINE PROTEASE INHIBITORS
-
Page/Page column 29, (2013/02/28)
Compounds of the formula (I) wherein One of A1 and A2 is N-CH3 and the other is CH; R1 is C1-C6alkyl, C1-C6haloalkyl, C3-C6cycloalkyl or oxetan-3-yl, wherein C3-C6cycloalkyl is optionally substituted with one, two or three fluoro or with CF3; R2a and R2b are independently selected from H, halo, C1-C4alkyl, C1-C4haloalkyl and C1- C4alkoxy; R3 is CH3 or F; n is 1, 2, 3 or 4; or a pharmaceutically acceptable salt, hydrate or N-oxide thereof for the use in the prophylaxis and/or treatment of a disorder characterised by inappropriate expression or activation of cathepsin S.
