52200-90-5Relevant articles and documents
Single-step, regioselective synthesis of diazadioxacalix[4]arenes and diazadioxa[14]cyclophanes bearing an alternating N/O-bridge pattern
Bizier, Nicholas P.,Vernamonti, Jack P.,Katz, Jeffrey L.
, p. 2303 - 2307 (2012)
Described is a single-step synthesis of diazadioxacalix[4]arenes and diazadioxa[14]cyclophanes bearing an alternating N/O-bridge substitution pattern. The macrocycles are formed regioselectively by condensation of 3-or 4-aminophenols with 1,5-d
Benzothiazolyl ureas are low micromolar and uncompetitive inhibitors of 17Β-HSD10 with implications to Alzheimer’s disease treatment
Aitken, Laura,Benek, Ondrej,Chribek, Matej,Dolezal, Rafael,Gunn-Moore, Frank,Hrabinova, Martina,Hroch, Lukas,Jun, Daniel,Kralova, Vendula,Kuca, Kamil,Lycka, Antonin,Musilek, Kamil,Prchal, Lukas,Schmidt, Monika,Vinklarova, Lucie,Zemanova, Lucie
, (2020/03/26)
Human 17β-hydroxysteroid dehydrogenase type 10 is a multifunctional protein involved in many enzymatic and structural processes within mitochondria. This enzyme was suggested to be involved in several neurological diseases, e.g., mental retardation, Parkinson’s disease, or Alzheimer’s disease, in which it was shown to interact with the amyloid-beta peptide. We prepared approximately 60 new compounds based on a benzothiazolyl scaffold and evaluated their inhibitory ability and mechanism of action. The most potent inhibitors contained 3-chloro and 4-hydroxy substitution on the phenyl ring moiety, a small substituent at position 6 on the benzothiazole moiety, and the two moieties were connected via a urea linker (4at, 4bb, and 4bg). These compounds exhibited IC50 values of 1–2 μM and showed an uncompetitive mechanism of action with respect to the substrate, acetoacetyl-CoA. These uncompetitive benzothiazolyl inhibitors of 17β-hydroxysteroid dehydrogenase type 10 are promising compounds for potential drugs for neurodegenerative diseases that warrant further research and development.
Nanocrystalline Pt-CeO2 as an efficient catalyst for a room temperature selective reduction of nitroarenes
Shukla, Astha,Singha, Rajib Kumar,Sasaki, Takehiko,Bal, Rajaram
supporting information, p. 785 - 790 (2015/03/03)
We have developed a new synthesis strategy to prepare Pt nanoparticles with size between 2 and 5 nm supported on CeO2 nanoparticles with size between 30 and 60 nm by the hydrothermal method in the presence of the surfactant cetyltrimethyl ammonium bromide (CTAB) and a polymer (PVP). It was found that the catalyst is highly active for the chemoselective hydrogenation of nitro compounds in aqueous medium in the presence of molecular hydrogen at room temperature (25 °C). The catalyst was characterized by XRD, ICP-AES, XPS, BET-surface area measurements, SEM, TEM and EXAFS. Different reaction parameters like reaction time, catalyst ratio, Pt loading etc. were studied in detail. The investigation revealed that the site of Pt plays a crucial role in the activity by favouring the reduction of nitro-compounds. The catalyst shows >99.9% conversion of nitro-compounds with 99% selectivity of amino compounds. The reusability of the catalyst was tested by conducting the experiment with the same catalyst and it was found that the catalyst does not change its activity and selectivity even after five reuses. This journal is
