52897-99-1

Basic information

• Product Name: bromo(bis-p-tolyl)methane
• Synonyms: bromo(bis-p-tolyl)methane
• CAS NO: 52897-99-1
• Molecular Weight: 275.188
• Mol File: 52897-99-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: bromo(bis-p-tolyl)methane(CAS DataBase Reference)
• NIST Chemistry Reference: bromo(bis-p-tolyl)methane(52897-99-1)
• EPA Substance Registry System: bromo(bis-p-tolyl)methane(52897-99-1)

Safety Data

• Hazardous Substances Data: 52897-99-1(Hazardous Substances Data)

Upstream product

• 693-03-8 n-butyl magnesium bromide 
• 885-77-8 4,4'-dimethylbenzhydrol 
• 925-90-6 ethylmagnesium bromide 
• 116664-90-5 4-(di-p-tolylmethoxy)benzonitrile 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 58493-75-7 bis(4-methyldiphenyl)methylium 
• 728-87-0 4,4'-Dimethoxybenzhydrol 
• 611-97-2 bis(p-methylphenyl)-methanone 
• 104-87-0 4-methyl-benzaldehyde 
• 106-38-7 para-bromotoluene 

Downstream Products

• 4957-14-6 4,4'-dimethyldiphenylmethane 
• 56074-61-4 1-(4-chloro-phenyl)-2,2-di-p-tolylethanone 
• 155960-71-7 4,4'-dimethylbenzhydryl fluoride 
• 18483-57-3 di(p-tolyl)(dimethylaminoethoxy)methane hydrochloride 
• 124419-84-7 1,1,3,3-Tetra(p-tolyl)-1-propen 
• 116664-90-5 4-(di-p-tolylmethoxy)benzonitrile 
• 102751-62-2 4,4′-((4-methoxyphenyl)methylene)bis(methylbenzene) 

Relevant articles and documents

Nucleofugality and nucleophilicity of fluoride in protic solvents

A series of p-substituted benzhydryl fluorides (diarylfluoromethanes) were prepared and subjected to solvolysis reactions, which were followed conductometrically. The observed first-order rate constants k1(25 °C) were found to follow the correlation equation log k1(25 °C) = sf(Nf + Ef), which allowed us to determine the nucleofuge-specific parameters Nf and sf for fluoride in different aqueous and alcoholic solvents. The rates of the reverse reactions were measured by generating benzhydrylium ions (diarylcarbenium ions) laser flash photolytically in various alcoholic and aqueous solvents in the presence of fluoride ions and monitoring the rate of consumption of the benzhydrylium ions by UV-vis spectroscopy. The resulting second-order rate constants k-1(20 °C) were substituted into the correlation equation log k-1 = sN(N + E) to derive the nucleophilicity parameters N and sN for fluoride in various protic solvents. Complete Gibbs energy profiles for the solvolysis reactions of benzhydryl fluorides are constructed.

N-heterocyclic carbene-catalyzed cross-coupling of aromatic aldehydes with activated alkyl halides

N-Heterocyclic carbene-catalyzed umpolung of aldehydes followed by their interception with diarylbromomethanes has been reported. This conceptually novel transition-metal-free cross-coupling of aldehydes with alkyl halides works well at low catalyst loadings and under mild reaction conditions leading to the formation of diaryl acetophenone derivatives in good yields. In addition, α-halo ketones and esters can also be used as aldehyde reaction partners.

Target directed chemotherapy of tumours of the sexual organs

The invention relates to dialkyltriazene-bearing estrogens and anti-estrogens that are suited for use as chemotherapeutic drugs for treating carcinomas of the sexual organs of humans and animals.