53157-63-4Relevant articles and documents
Synthesis and bioassay of antagonists of the luteinizing hormone releasing hormone having the azagly10 moiety
Folkers,Bowers,Lutz,et al.
, p. 1075 - 1081 (1982)
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Synthesis of 5 H -Pyrrolo[3,4- b ]pyrazine-Based Peptidomimetics
Biitseva, Angelina V.,Rudenko, Igor V.,Hordiyenko, Olga V.,Omelchenko, Iryna V.,Arrault, Axelle
, p. 3733 - 3740 (2015/11/28)
A range of 5H-pyrrolo[3,4-b]pyrazine-based peptidomimetics were designed, and their efficient synthesis starting from 5-imino-5H-pyrrolo[3,4-b]pyrazin-7-amine by subsequent interaction with N-protected amino acid hydrazides and amino acid esters with N,N-carbonyldiimidazole as the coupling agent was elaborated.
A new procedure for preparation of carboxylic acid hydrazides
Zhang, Xini,Breslav, Michael,Grimm, Jeffrey,Guan, Kailin,Huang, Aihua,Liu, Fuqiang,Maryanoff, Cynthia A.,Palmer, David,Patel, Mitul,Qian, Yun,Shaw, Charles,Sorgi, Kirk,Stefanick, Stephen,Xu, Dawei
, p. 9471 - 9474 (2007/10/03)
The standard method for preparing carboxylic acid hydrazides is hydrazinolysis of esters in alcoholic solutions. However, when applied to α,β-unsaturated esters, the main product typically is the pyrazolidinone resulting from an undesired Michael-type cyclization. Other alternative methodologies reported for direct preparation of hydrazides from acids are inefficient. We developed an efficient and general process, involving preforming activated esters and/or amides followed by reaction with hydrazine, for the preparation of hydrazides including those of α,β-unsaturated acids. This process gives the desired hydrazides in excellent yield and purity under mild conditions.
