53279-82-6

Basic information

• Product Name: 3-IODO-4-METHOXYBENZYL ALCOHOL
• Synonyms: Benzenemethanol, 3-iodo-4-methoxy-;(3-Iodo-4-methoxy-phenyl)-methanol
• CAS NO: 53279-82-6
• Molecular Formula: C₈H₉IO₂
• Molecular Weight: 264.0603
• Product Categories: Alcohols;Anisoles, Alkyloxy Compounds & Phenylacetates;Iodine Compounds;C7 to C8;Oxygen Compounds;Building Blocks;C7 to C8;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds
• Mol File: 53279-82-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 81-85 °C
• Boiling Point: 335.3 °C at 760 mmHg
• Flash Point: 156.6 °C
• Appearance: /
• Density: 1.768 g/cm³
• Vapor Pressure: 4.77E-05mmHg at 25°C
• Refractive Index: 1.617
• PKA: 14.18±0.10(Predicted)
• CAS DataBase Reference: 3-IODO-4-METHOXYBENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-IODO-4-METHOXYBENZYL ALCOHOL(53279-82-6)
• EPA Substance Registry System: 3-IODO-4-METHOXYBENZYL ALCOHOL(53279-82-6)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 53279-82-6(Hazardous Substances Data)

Usage

General Description

3-Iodo-4-methoxybenzyl alcohol is a chemical compound with the molecular formula C8H9IO2. It is a derivative of benzyl alcohol that contains an iodo and a methoxy group. 3-Iodo-4-methoxybenzyl alcohol is commonly used as a reagent in organic synthesis, particularly in the preparation of pharmaceuticals and agrochemicals. It has a wide range of applications in the field of medicinal chemistry and has been studied for its potential biological activities. Additionally, 3-Iodo-4-methoxybenzyl alcohol is also utilized as a precursor for the synthesis of various organic compounds due to its versatile reactivity and functional group compatibility.

InChI:InChI=1/C8H9IO2/c1-11-8-3-2-6(5-10)4-7(8)9/h2-4,10H,5H2,1H3

Upstream product

• 35387-93-0 3-iodo-4-methoxy-benzoic acid methyl ester 
• 2314-37-6 3-iodo-4-methoxybenzaldehyde 
• 105-13-5 4-Methoxybenzyl alcohol 

Downstream Products

• 91-61-2 6-methyl-1,2,3,4 tetrahydroquinoline 
• 60032-63-5 4-hydroxy-3-iodo-benzaldehyde 
• 2314-37-6 3-iodo-4-methoxybenzaldehyde 
• 1155702-70-7 3-[5-(hydroxymethyl)-2-methoxybenzyl]benzonitrile 

Relevant articles and documents

Pd-catalyzed atom-efficient cross-coupling of triarylbismuth reagents with protecting group-free iodophenylmethanols: Synthesis of biarylmethanols

An atom-efficient procedure for the synthesis of functionalized biarylmethanols via the Pd-catalyzed cross-coupling reactions of differently functionalized iodophenylmethanols and triarylbismuth reagents is described. This protecting group-free direct couplings of 2-, 3- or 4-iodophenylmethanols with triarylbismuth reagents afforded biarylmethanols in good to high yields.

Effect of water on the functionalization of substituted anisoles with iodine in the presence of F-TEDA-BF4 or hydrogen peroxide

Water was found to be a convenient reaction medium for functionalization of substituted anisoles using iodine in the presence of Selectfluor F-TEDA-BF 4 or hydrogen peroxide as mediators and oxidizers. Two types of functionalization were observ

Iodination of aromatic compounds under mild and solvent-free conditions

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