53636-15-0

Basic information

• Product Name: 2-Propanol, 1-(dimethylamino)-, (R)-
• CAS NO: 53636-15-0
• Molecular Formula: C5H13NO
• Molecular Weight: 103.164
• Mol File: 53636-15-0.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 2-Propanol, 1-(dimethylamino)-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propanol, 1-(dimethylamino)-, (R)-(53636-15-0)
• EPA Substance Registry System: 2-Propanol, 1-(dimethylamino)-, (R)-(53636-15-0)

Safety Data

• Hazardous Substances Data: 53636-15-0(Hazardous Substances Data)

Usage

Description

2-Propanol, 1-(dimethylamino)-, (R)is a chiral amine with the molecular formula C6H15NO. It is also known as (R)-1-(dimethylamino)propan-2-ol and is classified as a chiral amine. This colorless liquid with a faint odor is soluble in water and is used in various applications, including as a chiral auxiliary in organic synthesis reactions, a solvent, and a reagent for the synthesis of pharmaceutical compounds.

Uses

Used in Pharmaceutical Industry:
2-Propanol, 1-(dimethylamino)-, (R)is used as a reagent for the synthesis of pharmaceutical compounds, contributing to the development of new drugs and medicines.
Used in Organic Synthesis:
2-Propanol, 1-(dimethylamino)-, (R)is used as a chiral auxiliary in various organic synthesis reactions, playing a crucial role in the production of enantiomerically pure compounds.
Used as a Solvent:
2-Propanol, 1-(dimethylamino)-, (R)is utilized as a solvent in chemical processes, aiding in the dissolution and reaction of various substances.

Upstream product

• 108-16-7 1-methyl-2-N,N-dimethylaminoethanol 
• 87-69-4 L-Tartaric acid 
• 50-00-0 formaldehyd 
• 2799-16-8 (2R)-hydroxypropylamine 
• 15364-56-4 dimethylaminoacetone 
• 108-05-4 vinyl acetate 
• 200334-62-9 (R)-(-)-1-dimethylamino-2-propyl propanoate 
• 98956-88-8 1-(dimethylamino)-2-propanyl butyrate 
• 124-40-3 dimethyl amine 
• 15448-47-2 (R)-propylene oxide 
• 38145-93-6 1,2:3,4-di-O-isopropylidene-D-mannitol 

Downstream Products

• 1184843-57-9 SAR 020106 
• 1404095-27-7 C₂₂H₂₄FN₇O 
• 1404095-34-6 (R)-3-((1-(dimethylamino)propan-2-yl)oxy)-5-((4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)amino)pyrazine-2-carbonitrile 

Relevant articles and documents

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Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing

Pyrazolopyridine inhibitors with low micromolar potency for CHK1 and good selectivity against CHK2 were previously identified by fragment-based screening. The optimization of the pyrazolopyridines to a series of potent and CHK1-selective isoquinolines demonstrates how fragment-growing and scaffold morphing strategies arising from a structure-based understanding of CHK1 inhibitor binding can be combined to successfully progress fragment-derived hit matter to compounds with activity in vivo. The challenges of improving CHK1 potency and selectivity, addressing synthetic tractability, and achieving novelty in the crowded kinase inhibitor chemical space were tackled by multiple scaffold morphing steps, which progressed through tricyclic pyrimido[2,3-b] azaindoles to N-(pyrazin-2-yl)pyrimidin-4-amines and ultimately to imidazo[4,5-c]pyridines and isoquinolines. A potent and highly selective isoquinoline CHK1 inhibitor (SAR-020106) was identified, which potentiated the efficacies of irinotecan and gemcitabine in SW620 human colon carcinoma xenografts in nude mice. (Figure presented)

COMPOSITIONS CONTAINING (S)-BETHANECHOL AND THEIR USE IN THE TREATMENT OF INSULIN RESISTANCE, TYPE 2 DIABETES, GLUCOSE INTOLERANCE AND RELATED DISORDERS

The present invention provides pharmaceutical compositions comprising (S)-bethanechol or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable carrier and optionally at least one diabetes drug. The use of said composition in the treatment of insulin resistance, type 2 diabetes, impaired glucose tolerance and related disorders is also provided. The invention also provides for a kit comprising the pharmaceutical compositions and instructions for its use.