537049-40-4

Basic information

• Product Name: Tubacin
• Synonyms: Tubacin;N1-(4-((2R,4R,6S)-4-((4,5-diphenyloxazol-2-ylthio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-dioxan-2-yl)phenyl)-N8-hydroxyoctanediamide;N1-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy-octanediamide Tubacin;N1-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy-octanediamide;Tubacin, >=98%;N1-(4-((2R,4R,6S)-4-(((4,5-Diphenyloxazol-2-yl)thio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-di
• CAS NO: 537049-40-4
• Molecular Formula: C41H43N3O7S
• Molecular Weight: 721.88
• Product Categories: Inhibitors
• Mol File: 537049-40-4.mol
• Article Data: 1

Chemical Properties

• Appearance: white to tan/
• Storage Temp.: ?20°C
• Solubility: DMSO: ≥10mg/mL
• CAS DataBase Reference: Tubacin(CAS DataBase Reference)
• NIST Chemistry Reference: Tubacin(537049-40-4)
• EPA Substance Registry System: Tubacin(537049-40-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 537049-40-4(Hazardous Substances Data)

Usage

Uses

Tubacin is tubulin acetylation inducer that selectively inhibits histone deacetylase (HDAC6).

Biochem/physiol Actions

Tubacin triggers the release of reactive oxygen species and mediates caspase-3-independent apoptosis of Epstein-Barr virus (EBV)-positive Burkitt lymphoma cells. It suppresses the proliferation of acute lymphoblastic leukemia (ALL) cells and enhances the effect of chemotherapy to treat ALL cells. Tubacin prevents the epileptic activity and neuronal migration defects caused due to lowered expression of Srpx2 in rats.

Upstream product

• 1226792-11-5 C₄₂H₄₄N₂O₇S 

Relevant articles and documents

A new approach to tubacin

Tubacin, histone deacetylases, allyl borane reaction, stereoselective ketal formation, solution phase synthesis, hydroxyamide synthesis.A new simple synthesis of tubacin is reported. It entails the formation of the syn-1,3-diol unit and its stereoselective ketalization with a functionalized benzaldehyde derivative.