54395-37-8Relevant articles and documents
Preparation method of N - alkyl -4 -nitrophthalimide
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Paragraph 0049; 0051, (2021/10/27)
The invention discloses a preparation method of N - alkyl -4 -nitrophthalimide, which comprises the following steps of 1) mixing phthalic anhydride, alkyl aldehyde and inorganic amine, reacting under the action of hydrogen, cooling and crystallizing, and drying to obtain N -alkyl phthalimide. Step 2) The 1 alkylphthalimide obtained in step N -) is subjected to nitration reaction, and the product is purified and dried to obtain the N -alkyl -4 -nitrophthalimide. The alkyl aldehyde in step 1) is preferably an alkyl aldehyde of carbon 1 - 4. The preparation method has the advantages of wide raw material source, low price, simple process, easiness in large-scale production and the like. Through one-step synthesis, the reaction efficiency is high, the device is simple and easy to operate, and green and environment-friendly.
A process for preparing N - alkyl -4 - nitro phthalimide method (by machine translation)
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Paragraph 0052; 0053; 0054; 0067; 0068; 0069, (2019/02/19)
The invention belongs to the field of organic synthesis technology, and relates to a N - alkyl phthalimide as raw materials, nitric acid as nitrating agent, through the continuous flow at low temperature the nitration reaction preparation N - alkyl - 4 - nitro phthalic acid imide series products. The reaction time is short, the production cycle is short, intermittent reaction kettle solves the problem caused by the accumulation of the raw materials, the reaction process is more stable, significantly improves the reaction efficiency. The different structure of the micro-channel in the reactor to enhance the mass transfer, heat transfer performance, keep the reaction temperature constant, to avoid the phenomenon of the rack frame, to reduce by-product, at the same time improves the safety of the reaction process. The micro-channel of the mass transfer effect of strong in the reactor, so that the liquid - liquid reaction liquid to be fully mixed, in the reaction process, concentrated sulfuric acid, can greatly reduce the consumption of nitric acid, reduces the production of waste. (by machine translation)
Carbonylation Access to Phthalimides Using Self-Sufficient Directing Group and Nucleophile
Ji, Fanghua,Li, Jianxiao,Li, Xianwei,Guo, Wei,Wu, Wanqing,Jiang, Huanfeng
, p. 104 - 112 (2018/02/19)
Herein we report a novel palladium-catalyzed oxidative carbonylation reaction for the synthesis of phthalimides with high atom- and step-economy. In our strategy, the imine and H2O, which are generated in situ from the condensation of aldehyde and amine, serve as self-sufficient directing group and nucleophile, respectively. This method provides rapid access to phthalimides starting from readily available materials in a one-pot manner. Various phthalimide derivatives are constructed efficiently, including medicinally and biologically active phthalimide-containing compounds.