5453-99-6

Basic information

• Product Name: 4-Benzyl-morpholin-2-one
• Synonyms: 4-Benzyl-morpholin-2-one;N-Benzylmorpholine-2-one;NSC 18919
• CAS NO: 5453-99-6
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.22642
• Mol File: 5453-99-6.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 336.6°Cat760mmHg
• Flash Point: 141.1°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 0.000111mmHg at 25°C
• Refractive Index: 1.561
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 5.08±0.20(Predicted)
• CAS DataBase Reference: 4-Benzyl-morpholin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Benzyl-morpholin-2-one(5453-99-6)
• EPA Substance Registry System: 4-Benzyl-morpholin-2-one(5453-99-6)

Safety Data

• Hazardous Substances Data: 5453-99-6(Hazardous Substances Data)

Usage

Description

4-Benzyl-morpholin-2-one is a chemical compound with the molecular formula C13H15NO2. It is a morpholine derivative with a benzyl group attached to the nitrogen. 4-Benzyl-morpholin-2-one has been studied for its potential pharmacological properties, including its ability to act as a neurokinin-1 receptor antagonist and its potential as an anti-anxiety and anti-depressant agent. Additionally, 4-Benzyl-morpholin-2-one has been investigated for its potential use in the treatment of substance abuse and addiction. It has shown promise in preclinical studies and may have potential therapeutic applications in the future.

Uses

Used in Pharmaceutical Industry:
4-Benzyl-morpholin-2-one is used as a neurokinin-1 receptor antagonist for its potential role in treating various disorders related to the central nervous system. Its ability to block the neurokinin-1 receptor may contribute to its anti-anxiety and anti-depressant effects, making it a promising candidate for the development of new therapeutic agents.
Used in Mental Health Applications:
4-Benzyl-morpholin-2-one is used as an anti-anxiety agent for its potential to alleviate anxiety symptoms by modulating the neurokinin-1 receptor. This may provide a new approach to treating anxiety disorders and improving the quality of life for affected individuals.
Used in Antidepressant Therapy:
4-Benzyl-morpholin-2-one is used as an anti-depressant agent for its potential to improve mood and alleviate depressive symptoms. Its action as a neurokinin-1 receptor antagonist may contribute to its antidepressant effects, offering a novel therapeutic option for the treatment of depression.
Used in Substance Abuse and Addiction Treatment:
4-Benzyl-morpholin-2-one is used as a potential treatment for substance abuse and addiction due to its investigational role in modulating the neurokinin-1 receptor. This may help in reducing cravings and withdrawal symptoms, supporting the recovery process for individuals struggling with addiction.

InChI:InChI=1/C11H13NO2/c13-11-9-12(6-7-14-11)8-10-4-2-1-3-5-10/h1-5H,6-9H2

Upstream product

• 96-32-2 bromoacetic acid methyl ester 
• 104-63-2 N-Benzylethanolamine 
• 131543-46-9 Glyoxal 
• 5437-45-6 Benzyl bromoacetate 
• 100-39-0 benzyl bromide 
• 106-93-4 ethylene dibromide 
• 56-40-6 glycine 
• 100-52-7 benzaldehyde 
• 105-39-5 chloroacetic acid ethyl ester 
• 101-32-6 N-benzyl-diethanolamine 
• 770-37-6 2-(N-benzylidenamino)ethanol 
• 124948-51-2 (E)-2-(benzylideneamino)ethanol 

Downstream Products

• 120800-83-1 2-[Benzyl-(2-hydroxy-ethyl)-amino]-1-pyrrolidin-1-yl-ethanone 
• 118460-24-5 methyl 2-(benzyl(2-hydroxyethyl)amino)acetate 
• 120800-80-8 1-[Benzyl-(2-hydroxy-ethyl)-amino]-2-methyl-propan-2-ol 
• 120800-82-0 {2-[Benzyl-(2-hydroxy-ethyl)-amino]-acetylamino}-acetic acid methyl ester 
• 120800-81-9 N-Benzyl-2-[benzyl-(2-hydroxy-ethyl)-amino]-acetamide 
• 101-32-6 N-benzyl-diethanolamine 
• 73933-20-7 N-benzyl-2-hydroxymorpholine 
• 120800-79-5 N-benzyl-N-(2-hydroxyethyl)glycine 
• 118460-15-4 [(2-Acetoxy-ethyl)-benzyl-amino]-acetic acid methyl ester 
• 4441-15-0 morpholin-2-one 
• 503187-88-0 (6S)-6-Benzyl-morpholin-2-one 
• 1375855-46-1 2-(benzyl(2-hydroxyethyl)amino)-N-(2-(3',6'-bis(diethylamino)-3-oxospiro[isoindoline-1,9'-xanthene]-2-yl)ethyl)acetamide 
• 159706-87-3 4-benzyl-3-(4-fluorophenyl)morpholin-2-one 

Relevant articles and documents

Facile Access to the 12-Membered Macrocyclic Ligand PCTA and Its Derivatives with Carboxylate, Amide, and Phosphinate Ligating Functionalities

We describe a convenient synthetic pathway to access the 12-membered PCTA macrocycle, a polyaminocarboxylate ligand for which its M2+ and M3+ complexes are commonly associated with applications in biomedical diagnostics and radiother

Organocatalytic ring-opening polymerization of morpholinones: New strategies to functionalized polyesters

The oxidative lactonization of N-substituted diethanolamines with the Pd catalyst [LPd(OAc)]22+[OTf-]2 generates N-substituted morpholin-2-ones. The organocatalytic ring-opening polymerization of N-acyl morpholin-2-ones occurs readily to generate functionalized poly(aminoesters) with N-acylated amines in the polyester backbone. The thermodynamics of the ring-opening polymerization depends sensitively on the hybridization of the nitrogen of the heterocyclic lactone. N-Acyl morpholin-2-ones polymerize readily to generate polymorpholinones, but the N-aryl or N-alkyl substituted morpholin-2-ones do not polymerize. Experimental and theoretical studies reveal that the thermodynamics of ring opening correlates to the degree of pyramidalization of the endocyclic N-atom. Deprotection of the poly(N-Boc-morpholin-2-one) yields a water-soluble, cationic polymorpholinone.

A rhodamine appended tripodal receptor as a ratiometric probe for Hg 2+ ions

A new rhodamine appended tripodal receptor 1 has been designed and synthesized. The receptor selectively recognizes Hg2+ ions in CH 3CN-water (4:1, v/v; 10 μM tris HCl buffer, pH 7.0) by displaying a ratiometric change in emission. Additionally, the visual detection is possible by a sharp change in color. The receptor shows in vitro detection of Hg 2+ ions in human cervical cancer (HeLa) cells.