5464-77-7

Basic information

• Product Name: N,N-DIBENZYL-FORMAMIDE
• Synonyms: N,N-DIBENZYL-FORMAMIDE;N,N-bis(benzyl)formamide;N,N-bis(phenylmethyl)formamide;N,N-bis(phenylmethyl)methanamide;Dibenzylformamide;NSC 5982
• CAS NO: 5464-77-7
• Molecular Formula: C₁₅H₁₅NO
• Molecular Weight: 225.29
• Product Categories: pharmacetical;Amines;Aromatics
• Mol File: 5464-77-7.mol
• Article Data: 91

Chemical Properties

• Melting Point: 51-53°C
• Boiling Point: 426.3°Cat760mmHg
• Flash Point: 159.4°C
• Appearance: /
• Density: 1.104g/cm³
• Vapor Pressure: 1.79E-07mmHg at 25°C
• Refractive Index: 1.5782 (589.3 nm 25℃)
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility: Chloroform
• PKA: -0.50±0.70(Predicted)
• CAS DataBase Reference: N,N-DIBENZYL-FORMAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIBENZYL-FORMAMIDE(5464-77-7)
• EPA Substance Registry System: N,N-DIBENZYL-FORMAMIDE(5464-77-7)

Safety Data

• Hazardous Substances Data: 5464-77-7(Hazardous Substances Data)

Usage

Description

N,N-Dibenzylformamide, with the CAS number 5464-77-7, is a white solid compound that is primarily utilized in the field of organic synthesis. It is known for its unique chemical properties that make it a valuable component in various chemical reactions and processes.

Uses

Used in Organic Synthesis:
N,N-Dibenzylformamide is used as a synthetic intermediate for the production of various organic compounds. Its application in this field is due to its ability to participate in a range of chemical reactions, such as condensation, substitution, and rearrangement reactions, which are essential for the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N,N-Dibenzylformamide is used as a building block for the development of new drugs. Its unique chemical structure allows it to be modified and functionalized to create novel drug candidates with potential therapeutic applications.
Used in Chemical Research:
N,N-Dibenzylformamide is also employed in chemical research as a model compound to study various reaction mechanisms and to develop new synthetic methodologies. Its reactivity and structural features make it an ideal candidate for exploring new chemical transformations and understanding the underlying principles of organic chemistry.
Used in Material Science:
In the field of material science, N,N-Dibenzylformamide can be used as a component in the development of new materials with specific properties. Its incorporation into polymers or other materials can lead to the creation of materials with enhanced characteristics, such as improved stability, reactivity, or selectivity.

InChI:InChI=1/C15H15NO/c17-13-16(11-14-7-3-1-4-8-14)12-15-9-5-2-6-10-15/h1-10,13H,11-12H2

Upstream product

• 109-94-4 formic acid ethyl ester 
• 103-49-1 dibenzylamine 
• 122-78-1 phenylacetaldehyde 
• 622-79-7 benzyl azide 
• 64-18-6 formic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 124-38-9 carbon dioxide 
• 72773-04-7 N-formylbenzotriazole 
• 55245-68-6 N,N-dibenzyl-1H-imidazole-1-carboxamide 
• 96-26-4 dihydroxyacetone 
• 79-14-1 glycolic Acid 
• 107-31-3 Methyl formate 
• 591-50-4 iodobenzene 
• 201230-82-2 carbon monoxide 

Downstream Products

• 220247-77-8 1-(N,N-dibenzylamino)-2-ethenyl-3,3-dimethylcyclopropane 
• 220247-74-5 1-(N,N-dibenzylamino)-2-ethenylcyclopropane 
• 6708-17-4 bicyclooctyl 
• 497163-57-2 tert-butyl (1R,5S,6s)-6-(N,N-dibenzylamino)-3-azabicyclo[3.1.0]hexane-3-carboxylate 
• 176209-29-3 N,N-dibenzylaminocyclopropane 
• 873544-26-4 tert-butyl (2S,2'R,3R,4R)-N_α-Boc-3,4-(N,N-dibenzylaminomethano)prolinate 
• 916763-87-6 (2R,1'S,3S,4S)-Nα-Boc-O-tert-butyldimethylsilyl-3,4-(dibenzylaminomethano)prolinol 

Relevant articles and documents

Conversion of (1-heterodiene)tricarbonyliron(0) complexes into (2-aminohomodiene)tricarbonyliron(0) complexes

Treatment of (1-azadiene)tricarbonyliron(0) complex 1 with lithiated amines leads to attack at a metal carbonyl and the formation of formamides, whereas complexes 2 and 3 undergo deprotonation of the methyl group at C-2 followed by a rearrangement to form (2-aminohomodiene)tricarbonyliron(0) complexes 8 or 10 in good yield.

Nickel-Catalyzed Amination of Aryl Chlorides with Amides

A nickel-catalyzed amination of aryl chlorides with diverse amides via C-N bond cleavage has been realized under mild conditions. A broad substrate scope with excellent functional group tolerance at a low catalyst loading makes the protocol powerful for synthesizing various aromatic amines. The aryl chlorides could selectively couple to the amino fragments rather than the carbonyl moieties of amides. Our protocol complements the conventional amination of aryl chlorides and expands the usage of inactive amides.

Preparation method of formamide compound

The invention belongs to CO. 2 The invention relates to the technical field of activation conversion and related chemistry, and provides a preparation method of a formamide compound, which uses carbon dioxide. The amide compound and phenylsilane are used as raw materials, and the formamide compound is synthesized under the action of the nano porous palladium catalyst. The invention mainly provides a novel simple catalytic system and utilizes CO. 2 C1 The catalytic system has the advantages of mild reaction conditions, simple experiment operation, good functional group compatibility and the like. Because carbon dioxide is abundant, cheap and easily available and renewable C1 , The invention has great application value and social economic benefits.