55094-97-8Relevant articles and documents
Synthesis of (S)-3-hydroxytetrahydropyran from L-glutamic acid
Geng, Yang,Zheng, Maolin,Li, Jingya,Zou, Dapeng,Wu, Yusheng,Wu, Yangjie
, p. 3966 - 3969 (2017)
A concise synthesis of (S)-3-hydroxytetrahydropyran from natural L-glutamic acid has been developed. The intramolecular etherification starting from 1,5-diol was promoted by trifluoromethanesulfonic anhydride. The clinnamates of the alcohols were prepared
Synthesis of Two Epimers of Pseudopaline
Arnoux, Pascal,Cavelier, Florine,Cullia, Gregorio,Fanelli, Roberto,Voulhoux, Romé
supporting information, (2020/07/06)
Opines are a known group of compounds characterized by an elevated polarity. Recently, two new members of this class, staphylopine and pseudopaline, have been identified in Staphylococcus aureus and Pseudomonas aeruginosa, respectively. These molecules are metal chelators that contribute to the growth of bacteria in particularly metal-poor environment. Different evidences suggest that these molecules might have an important role in the development of pulmonary infections in humans. Considering the impact of P. aeruginosa infections in cystic fibrosis patients (prevalence up to 70 percent), pseudopaline has risen interest as potential source of new therapeutic intervention. We present herein a straightforward synthetic approach for the synthesis of the two epimers of pseudopaline. Starting from a chiral building block, we attribute the absolute configuration to the two obtained diasteroisomers.
3-benzyloxy-tetrahydropyrane, preparation method thereof and preparation method of single-configured tetrahydropyrane-3-cyclitol
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Paragraph 0046; 0047; 0048; 0049, (2017/10/27)
The invention relates to 3-benzyloxy-tetrahydropyrane, a preparation method thereof and a preparation method of single-configured tetrahydropyrane-3-cyclitol, and belongs to the technical field of medicines. The 3-benzyloxy-tetrahydropyrane has a structur