5535-52-4

Basic information

• Product Name: P-TOLYL VINYL SULPHONE
• Synonyms: 1-Methyl-4-(vinylsulfonyl)benzene;4-Methylphenyl vinyl sulfone;p-Tolyl vinyl sulfone;p-Tosylethylene;Sulfone, p-tolyl vinyl;P-TOLYL VINYL SULPHONE;4-Methylphenyl vinyl sulphone;p-Tolylvinylsulfone,98%
• CAS NO: 5535-52-4
• Molecular Formula: C₉H₁₀O₂S
• Molecular Weight: 182.24
• Mol File: 5535-52-4.mol
• Article Data: 15

Chemical Properties

• Melting Point: 62-64°C
• Boiling Point: 324.1 °C at 760 mmHg
• Flash Point: 181.5 °C
• Appearance: /
• Density: 1.145 g/cm³
• Refractive Index: 1.631
• CAS DataBase Reference: P-TOLYL VINYL SULPHONE(CAS DataBase Reference)
• NIST Chemistry Reference: P-TOLYL VINYL SULPHONE(5535-52-4)
• EPA Substance Registry System: P-TOLYL VINYL SULPHONE(5535-52-4)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 5535-52-4(Hazardous Substances Data)

Usage

General Description

P-Tolyl vinyl sulphone is a chemical compound with the molecular formula C9H10O2S. It is a reactive and versatile compound used in the synthesis of various pharmaceuticals, dyes, and fine chemicals. P-Tolyl vinyl sulphone is a strong electrophile and is widely employed in the field of organic chemistry as a versatile building block for the creation of complex molecules. Its reactivity makes it a valuable tool for the modification and functionalization of a wide range of organic compounds, and its usage in the pharmaceutical industry has been explored for the development of new drugs and medications. Safety precautions should be taken when handling this compound as it can cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C18H16N4O2/c1-24-16-9-7-14(8-10-16)18(23)22-20-12-15-11-19-21-17(15)13-5-3-2-4-6-13/h2-12,20H,1H3,(H,22,23)/b15-12-

Upstream product

• 14184-30-6 1-[(2-bromoethyl)thio]-4-methylbenzene 
• 624-31-7 4-tolyl iodide 
• 351186-41-9 4-methyl-N-morpholin-4-ylbenzenesulfonamide 
• 106-93-4 ethylene dibromide 
• 106-45-6 para-thiocresol 
• 22381-53-9 2-chloroethyl-p-toluenesulfonate 
• 74-85-1 ethene 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 71700-50-0 1-(tert-butyldimethylsilyloxy)-3-phenyl-2-propene 
• 112471-52-0 2-tosylethyl 3-phenylpropanoate 
• 112471-53-1 2-tosylethyl 3-phenyl-2-propenoate 
• 94460-95-4 2-(4-Tolyl-sulfonyl)-aethoxycarbonylanilin 
• 75-50-3 trimethylamine 
• 121-44-8 triethylamine 

Downstream Products

• 61097-92-5 N-p-Tolylsulfonylethyl-methylamin 
• 159899-18-0 1-nitro-3-tosylpropane 
• 50702-03-9 β-tosylethylamine 
• 15717-50-7 E-ditosylethene 
• 54606-95-0 1-Chlor-2-phenylethyl-p-tolyl-sulfon 
• 93897-58-6 1-Brom-2-(p-nitro-phenyl)-ethyl-p-tolyl-sulfon 
• 92426-24-9 1-Chlor-2-(p-nitro-phenyl)-ethyl-p-tolylsulfon 
• 16236-65-0 1-[2-(toluene-4-sulfonyl)-ethyl]-piperidine 
• 22952-14-3 1,2-bis(p-tolylsulfonyl)ethane 
• 62021-95-8 2-(7-Cumylperoxy)ethyltosylat 
• 62021-94-7 2-(t-Butylperoxy)-ethyltosylat 

Relevant articles and documents

Metal-free visible-light-promoted C(sp3)-H functionalization of aliphatic cyclic ethers using trace O2

Presented is a light-promoted C-C bond forming reaction yielding sulfone and phosphate derivatives at room temperature in the absence of metals or photoredox catalyst. This transformation proceeds in neat conditions through an auto-oxidation mechanism which is maintained through the leaching of trace amounts of O2 as sole green oxidant. This journal is

Diastereoselective Monofluorocyclopropanation Using Fluoromethylsulfonium Salts

Diarylfluoromethylsulfonium salts, alternatives to freons or advanced fluorinated building blocks, are bench stable and easy-to-use sources of direct fluoromethylene (:CHF) transfer to alkenes. These salts enabled development of a trans-selective monofluorinated Johnson-Corey-Chaykovsky reaction with vinyl sulfones or vinyl sulfonamides to access synthetically challenging monofluorocyclopropane scaffolds. The described method offers rapid access to monofluorinated cyclopropane building blocks with further functionalization opportunities to deliver more complex synthetic targets diastereoselectively.

Difluoro- and trifluoro diazoalkanes-complementary approaches in batch and flow and their application in cycloaddition reactions

Herein we report on applications of fluorinated diazoalkanes in cycloaddition reactions, with the emphasis on studying subtle differences between diverse fluorinated diazo compounds. These differences led to two major synthetic protocols in batch and flow that allow the safe and scalable synthesis of fluoroalkyl-, sulfone-substituted pyrazolines.