56147-28-5Relevant articles and documents
Synthesis and structure-activity relationships of novel antiseptics
Tsubouchi, Hidetsugu,Ohguro, Kinue,Yasumura, Koichi,Ishikawa, Hiroshi,Kikuchi, Mikio
, p. 1721 - 1724 (1997)
For the purpose of developing new antiseptics, we searched for compounds having high biocidal activity covering both gram-positive and gram-negative bacteria. Accordingly, we designed 1,5-disubstituted biguanides and synthesized them using two alternative efficient reaction schemes. The bactericidal activity of these biguanides was assayed by the micro titration plate method. Among the biguanides synthesized, 3,4-dichlorobenzyl derivatives were found to exhibit particularly high bactericidal activity. Ultimately, compound II was chosen as a candidate novel antiseptic, which is currently under continued evaluation.