56441-97-5

Basic information

• Product Name: METHYL 4-BENZYLOXY-3-METHOXYBENZOATE
• Synonyms: METHYL BENZYL VANILLATE;METHYL 4-BENZYLOXY-3-METHOXYBENZOATE;RARECHEM AL BF 0064;Benzoic acid, 3-Methoxy-4-(phenylMethoxy)-, Methyl ester;4-Benzyloxy-3-Methoxybenzoic Acid Methyl Ester;-3-methoxybenzoate;Methyl 4-(benzyloxy)
• CAS NO: 56441-97-5
• Molecular Formula: C₁₆H₁₆O₄
• Molecular Weight: 272.3
• Product Categories: Aromatic Esters
• Mol File: 56441-97-5.mol
• Article Data: 40

Chemical Properties

• Boiling Point: 400.12 °C at 760 mmHg
• Flash Point: 176.641 °C
• Appearance: /
• Density: 1.154 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DCM, Ethyl Acetate
• CAS DataBase Reference: METHYL 4-BENZYLOXY-3-METHOXYBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4-BENZYLOXY-3-METHOXYBENZOATE(56441-97-5)
• EPA Substance Registry System: METHYL 4-BENZYLOXY-3-METHOXYBENZOATE(56441-97-5)

Safety Data

• Hazardous Substances Data: 56441-97-5(Hazardous Substances Data)

Usage

Description

METHYL 4-BENZYLOXY-3-METHOXYBENZOATE, also known as 4-Benzyloxy-3-methoxybenzoic Acid Methyl Ester, is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its ester functional group and aromatic ring structure, which contribute to its reactivity and utility in chemical reactions.

Uses

Used in Pharmaceutical Industry:
METHYL 4-BENZYLOXY-3-METHOXYBENZOATE is used as an intermediate in the synthesis of Clomiphene (C587025), a synthetic estrogen agonist-antagonist. It plays a vital role in the production of this medication, which is primarily used to treat infertility in women by stimulating ovulation. METHYL 4-BENZYLOXY-3-METHOXYBENZOATE's structural properties allow it to participate in various chemical reactions, facilitating the synthesis of Clomiphene and other related pharmaceuticals.

Upstream product

• 3943-74-6 4-hydroxy-3-methoxybenzoic acid methyl ester 
• 100-39-0 benzyl bromide 
• 67-56-1 methanol 
• 1486-53-9 4-(benzyloxy)-3-methoxybenzoic acid 
• 100-44-7 benzyl chloride 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 121-33-5 vanillin 
• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 3943-74-6 4-hydroxy-3-methoxybenzoic acid methyl ester 

Relevant articles and documents

Transition Metal-Free Regioselective Remote C?H Bond 2,2,2-Trifluoroethoxylation of 8-Aminoquinoline Derivatives at the C5 Position

The regioselective 2,2,2-trifluoroethoxylation at the C5 position of amides derived from the 8-aminoquinoline has been developed. In the presence of PIDA, an unprecedented and undirected transition metal-free transformation was achieved using the readily available and appealing 2,2,2-trifluoroethanol as the fluorinated source. The selective distal 2,2,2-trifluoroethoxylation of an array of amides was achieved in moderate to good yields (12 examples, up to 61 % yield). This approach provided efficient access to high-value added fluorinated quinoline derivatives, key building blocks for bulk and fine chemical industry.

FUSED HETEROCYCLIC BENZODIAZEPINE DERIVATIVES AND USES THEREOF

The present disclosure provides compounds and compositions capable of extending lifespan, and methods of use thereof.

Heterocyclic compound, preparation method and application thereof

The invention relates to a heterocyclic compound in the technical field of medicines. The compound is represented by a structural general formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, X, Y, Z, Cy1, Cy2, m, n and t have the meanings given in the specification; in addition, the invention also discloses an application of the compound and the pharmaceuticallyacceptable salt thereof in preparation of drugs for treating diseases caused by abnormal high expression of tyrosine kinase, especially application in preparation of drugs for treating and preventingcancers.