5675-51-4Relevant articles and documents
MELYNES, POLYACETYLENE CONSTITUENTS FROM A VANUATU MARINE SPONGE
Quinoa, Emilio,Crews, Phillip
, p. 2037 - 2040 (1988)
The structures of three long chain polyeneyne triols, melynes A, B, C are established from degradation reactions, from NMR data and from extensive HREIMS data.
Multi-enzymatic cascade reactions with Escherichia coli-based modules for synthesizing various bioplastic monomers from fatty acid methyl esters?
Jung, Hyunsang,Kim, Byung-Gee,Kim, Ye Chan,Park, Beom Gi,Patil, Mahesh D.,Sarak, Sharad,Yoo, Hee-Wang,Yun, Hyungdon
supporting information, p. 2222 - 2231 (2022/04/03)
Multi-enzymatic cascade reaction systems were designed to generate biopolymer monomers using Escherichia coli-based cell modules, capable of carrying out one-pot reactions. Three cell-based modules, including a ω-hydroxylation module (Cell-Hm) to convert fatty acid methyl esters (FAMEs) to ω-hydroxy fatty acids (ω-HFAs), an amination module (Cell-Am) to convert terminal alcohol groups of the substrate to amine groups, and a reduction module (Cell-Rm) to convert the carboxyl groups of fatty acids to alcohol groups, were constructed. The product-oriented assembly of these cell modules involving multi-enzymatic cascade reactions generated ω-ADAs (up to 46 mM), α,ω-diols (up to 29 mM), ω-amino alcohols (up to 29 mM) and α,ω-diamines (up to 21 mM) from 100 mM corresponding FAME substrates with varying carbon chain length (C8, C10, and C12). Finally 12-ADA and 1,12-diol were purified with isolated yields of 66.5% and 52.5%, respectively. The multi-enzymatic cascade reactions reported herein present an elegant ‘greener’ alternative for the biosynthesis of various biopolymer monomers from renewable saturated fatty acids.
Preparation of a Series of Supported Nonsymmetrical PNP-Pincer Ligands and the Application in Ester Hydrogenation
Konrath, Robert,Spannenberg, Anke,Kamer, Paul C. J.
supporting information, p. 15341 - 15350 (2019/11/14)
In contrast to their symmetrical analogues, nonsymmetrical PNP-type ligand motifs have been less investigated despite the modular pincer structure. However, the introduction of mixed phosphorus donor moieties provides access to a larger variety of PNP ligands. Herein, a facile solid-phase synthesis approach towards a diverse PNP-pincer ligand library of 14 members is reported. Contrary to often challenging workup procedures in solution-phase, only simple workup steps are required. The corresponding supported ruthenium-PNP catalysts are screened in ester hydrogenation. Usually, industrially applied heterogeneous catalysts require harsh conditions in this reaction (250–350 °C at 100–200 bar) often leading to reduced selectivities. Heterogenized reusable Ru-PNP catalysts are capable of reducing esters and lactones selectively under mild conditions.
Pellynols M?O, cytotoxic polyacetylenic alcohols from a Niphates sp. marine sponge
Wang, Jie,Liu, Li-Yun,Liu, Lei,Zhan, Kai-Xuan,Jiao, Wei-Hua,Lin, Hou-Wen
, p. 3701 - 3706 (2018/05/25)
Three new polyacetylenic alcohols, pellynols M?O (1–3), along with two known ones, melyne A (4) and melyne B (5), were isolated from a Niphates sp. marine sponge collected off the South China Sea. The structures of new compounds were determined based on a combination of 1D and 2D NMR analysis, ESI-MSn fragmentation, and chemical (ozonolysis) method. Their absolute configurations were assigned by modified Mosher's method. All the isolates showed potent cytotoxic activity against PC9 and HepG2 human cancer cell lines with IC50 values of 2.9–7.6 μM.