56824-84-1

Basic information

• Product Name: Methanone, (5-chloro-2-thienyl)phenyl-
• Synonyms: 5-Benzoyl-5-chlorthiophen;HMS1627H05;5-chlorothien-2-yl phenyl ketone;2-benzoyl-5-chlorothiophene
• CAS NO: 56824-84-1
• Molecular Formula: C11H7ClOS
• Molecular Weight: 222.695
• Mol File: 56824-84-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Methanone, (5-chloro-2-thienyl)phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (5-chloro-2-thienyl)phenyl-(56824-84-1)
• EPA Substance Registry System: Methanone, (5-chloro-2-thienyl)phenyl-(56824-84-1)

Safety Data

• Hazardous Substances Data: 56824-84-1(Hazardous Substances Data)

Upstream product

• 96-43-5 2-thienyl chloride 
• 98-88-4 benzoyl chloride 
• 42518-98-9 5-chlorothiophene-2-carbonyl chloride 
• 71-43-2 benzene 
• 2873-18-9 5-bromo-2-chlorothiophene 
• 24065-33-6 5-Chlorothiophene-2-carboxylic acid 
• 201230-82-2 carbon monoxide 
• 369-57-3 benzenediazonium tetrafluoroborate 
• 93-97-0 benzoic acid anhydride 

Downstream Products

• 103565-94-2 (5-chloro-4-nitro-[2]thienyl)-(3-nitro-phenyl)-ketone 
• 95729-24-1 (5-Chlor-4-nitro-2-thienyl)-phenylmethanon 
• 61464-22-0 phenyl-(5-chlorothiophen-2-yl)methanol 
• 121802-21-9 3-[Chloro-(5-chloro-thiophen-2-yl)-phenyl-methyl]-benzo[b]thiophene 
• 121802-26-4 1-[Benzo[b]thiophen-3-yl-(5-chloro-thiophen-2-yl)-phenyl-methyl]-1H-imidazole 
• 1354558-43-2 phenyl(5-tosylthiophen-2-yl)methanone 
• 1354558-44-3 phenyl(5-(phenylsulfonyl)thiophen-2-yl)methanone 
• 1354558-45-4 (5-(cyclopropylsulfonyl)thiophen-2-yl)(phenyl)methanone 

Relevant articles and documents

Preparation of acylthiophenes by iron(III) chloride catalyzed reactions of tris(2-thienyl)stibanes with acyl chlorides

The reactions of tris(2-thienyl)stibanes with various acyl chlorides, using a catalytic amount of iron(III) chloride, afforded 2-acylthiophenes. Iron(III) chloride is presumed to act as a Lewis acid, and the ipso substituent of each 2-thienyl group of tris(2-thienyl)stibane is replaced with an acyl group. The reaction is highly atom-efficient in that all three thiophene rings of tris(2-thienyl)stibane take part in the reaction. The reaction procedure is so simple that it can also be carried out under solvent-free and aerobic conditions.

Novel 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. A structure-activity relationship investigation

1-[2-(Diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles (DAMNIs) is a novel family of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) active at submicromolar concentration. Replacement of one phenyl ring of 1-[2-(diphenylmethoxy)ethyl]-2-methyl-5-nitroimidazole (4) with heterocyclic rings, such as 2-thienyl or 3-pyridinyl, led to novel DAMNIs with increased activity. In HIV-1 WT cell-based assay the racemic 1-{2-[α-(thiophen-2-yl) phenylmethoxy]ethyl}-2-methyl-5-nitroimidazole (7) (EC50 = 0.03 μM) proved 5 times more active than compound 4. Docking experiments showed that the introduction of a chiral center would not affect the binding of both (R)-7 and (S)-7. The internal scoring function of the Autodock program calculated the same inhibition constant (Ki = 7.9 nM) for the two enantiomers. Compounds 7 (ID50 = 8.25 μM) were found more active than efavirenz (ID50 = 25 μM) against the viral RT carrying the K103N mutation, suggesting for these compounds a potential use in efavirenz based anti-AIDS regimens.

Studies on the Chemistry of Thienoanellated O,N- and S,N-Containing Heterocycles, X: Synthesis of 2-Substituted Thieno-Diltiazem Derivatives

The syntheses of 2-acetyl-, 2-benzyl-, and 2-ethyl-thieno-diltiazem derivatives are described starting from the corresponding 5-substituted 3-nitro-2-thiophenthiol via reaction with racemic methyl trans-3-(4-methoxyphenyl)-glycidate under different condit