569679-90-9

Basic information

• Product Name: 4-Hexenoic acid, 3-[[(1S)-1-phenylethyl][(phenylmethoxy)carbonyl]amino]-2-(2-propenyl)-, 1,1-dimethylethyl ester, (2S,3S,4E)-
• CAS NO: 569679-90-9
• Molecular Formula: C29H37NO4
• Molecular Weight: 463.617
• Mol File: 569679-90-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Hexenoic acid, 3-[[(1S)-1-phenylethyl][(phenylmethoxy)carbonyl]amino]-2-(2-propenyl)-, 1,1-dimethylethyl ester, (2S,3S,4E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hexenoic acid, 3-[[(1S)-1-phenylethyl][(phenylmethoxy)carbonyl]amino]-2-(2-propenyl)-, 1,1-dimethylethyl ester, (2S,3S,4E)-(569679-90-9)
• EPA Substance Registry System: 4-Hexenoic acid, 3-[[(1S)-1-phenylethyl][(phenylmethoxy)carbonyl]amino]-2-(2-propenyl)-, 1,1-dimethylethyl ester, (2S,3S,4E)-(569679-90-9)

Safety Data

• Hazardous Substances Data: 569679-90-9(Hazardous Substances Data)

Upstream product

• 31139-36-3 dibenzyl dicarbonate 
• 569679-87-4 (2S,3S,4E,αS)-tert-butyl 2-allyl-3-(N-α-methylbenzylamino)-hex-4-enoate 

Downstream Products

• 569679-98-7 (1S,2S,αS)-tert-butyl 2-N-α-methylbenzylamino-N-benzyloxycarbonyl-cyclopent-3-ene-1-carboxylate 
• 128052-92-6 (1S,2S)-2-aminocyclopentanecarboxylic acid hydrochloride 

Relevant articles and documents

Asymmetric synthesis of cyclic β-amino acids and cyclic amines via sequential diastereoselective conjugate addition and ring closing metathesis

Diastereoselective conjugate addition of lithium (S)-N-allyl-N-α-methylbenzylamide to a range of α,β-unsaturated esters followed by ring closing metathesis is used to afford efficiently a range of substituted cyclic β-amino esters in high d.e. Alternatively, conjugate addition to α,β-unsaturated Weinreb amides, functional group conversion and ring closing metathesis affords cyclic amines in high d.e. The further application of this methodology to the synthesis of a range of carbocyclic β-amino esters via conjugate addition, enolate alkylation and ring closing metathesis is also described. Application of this methodology affords, after deprotection, (S)-homoproline, (S)-homopipecolic acid, (S)-coniine and (1S,2S)-trans-pentacin.