5699-40-1Relevant articles and documents
Triophamine, a Unique Diacylguanidine from the Dorid Nudibranch Triopha catalinae (Cooper)
Gustafson, Kirk,Andersen, Raymond J.
, p. 2167 - 2169 (1982)
Triophamine (1), a symmetrical diacylguanidine, has been isolated from skin extracts of the dorid nudibranch Triopha catalinae.The proposed structure of 1 was based on interpretation of the mass, IR, UV, 1H NMR, and 13C NMR spectra.It was verified by comparison with diacetylguanidine (3) and by base-catalyzed hydrolysis to guanidine and 2,4-diethyl-4-hexenoic acid (6).
Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2
Blake, James F.,Gaudino, John J.,De Meese, Jason,Mohr, Peter,Chicarelli, Mark,Tian, Hongqi,Garrey, Rustam,Thomas, Allen,Siedem, Christopher S.,Welch, Michael B.,Kolakowski, Gabrielle,Kaus, Robert,Burkard, Michael,Martinson, Matthew,Chen, Huifen,Dean, Brian,Dudley, Danette A.,Gould, Stephen E.,Pacheco, Patricia,Shahidi-Latham, Sheerin,Wang, Weiru,West, Kristina,Yin, Jianping,Moffat, John,Schwarz, Jacob B.
, p. 2635 - 2639 (2014/06/09)
The discovery and optimization of a series of tetrahydropyridopyrimidine based extracellular signal-regulated kinase (Erks) inhibitors discovered via HTS and structure based drug design is reported. The compounds demonstrate potent and selective inhibition of Erk2 and knockdown of phospho-RSK levels in HepG2 cells and tumor xenografts.
PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS
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, (2010/03/02)
The invention relates to a process for straightening keratin fibres, comprising: (i) a step in which a straightening composition containing at least two denaturing agents is applied to the keratin fibres, (ii) a step in which the temperature of the keratin fibres is raised, using a heating means, to a temperature of between 110 and 250° C.