57-13-6 Usage
Description
Urea, also known as carbamide, is a colorless, crystalline substance that is an important nitrogen-containing compound found in mammal urine. It is highly soluble in water and contains 46.7% nitrogen. Urea is a stable compound with good storage properties, making it the most commonly used nitrogen fertilizer. It is synthesized by reacting liquid ammonia with carbon dioxide, producing ammonium carbamate, which is then dehydrated to form urea.
Uses
Used in Agriculture:
Urea is used as a nitrogen-release fertilizer for providing a concentrated source of fixed nitrogen to soils. It is highly soluble in water, making it suitable for use in fertilizer solutions and foliar feed fertilizers. Urea is also used in multi-component solid fertilizer formulations and as a supplement in livestock feeds to assist protein synthesis.
Used in Pharmaceutical Industry:
Urea reacts with malonic acid to form barbituric acid, which is used in the production of various acylureas and urethanes for use as sedatives and hypnotics.
Used in Chemical Industry:
Urea is a raw material for the manufacture of urea-formaldehyde resins and urea-melamine-formaldehyde used in marine plywood. It is also used to trap organic compounds in the form of clathrates, which can be used to separate mixtures, and has been used in the production of aviation fuel and lubricating oils, and in the separation of paraffin.
Used in Laboratory:
Urea, in concentrations up to 10 M, is a powerful protein denaturant that disrupts noncovalent bonds in proteins, increasing the solubility of some proteins. It can also serve as a hydrogen source for subsequent power generation in fuel cells and is used to make fixed brain tissue transparent to visible light while preserving fluorescent signals from labeled cells.
Used in Automobile Systems:
Urea is used in SNCR and SCR reactions to reduce NOx pollutants in exhaust gases from combustion sources, such as power plants and diesel engines. The BlueTec system, for example, injects a water-based urea solution into the exhaust system, where the ammonia produced by decomposition of the urea reacts with nitrogen oxide emissions and is converted into nitrogen and water within the catalytic converter.
Used in Others:
Urea has various other applications, including as a stabilizer in nitrocellulose explosives, a component of animal feed, a non-corroding alternative to rock salt for road de-icing, a flavor-enhancing additive for cigarettes, a main ingredient in hair removers, a browning agent in factory-produced pretzels, an ingredient in hair conditioners and skin care products, a reactant in ready-to-use cold compresses for first-aid use, a cloud seeding agent, a flame-proofing agent, an ingredient in tooth whitening products, an ingredient in dish soap, and a nutrient used in plankton nourishment experiments for geoengineering purposes.
Chemical structure
Lewis structure
Ball-and-stick diagram
Space-filling model
Urea, also known as carbamide, is an organic compound with chemical formula CO (NH2)2. This amide has two –NH2 groups joined by a carbonyl (C=O) functional group.
History
Pure urea was first isolated from urine in 1727 by the Dutch scientist Herman Boerhaave, and he extracted urea from urine by working with the concentated-by-boiling residue. But if only not considering the purity of urea, the discovery of urea should be attributed to the French chemist Hilaire Rouelle, and he prepared urea (or its addition compound with sodium chloride) from urine some time before 1727.
In 1828, just 55 years after its discovery, urea became the first organic compound to be synthetically formulated, this time by a German chemist named Friedrich W?hler, one of the pioneers of organic chemistry. It was found when Wohler attempted to synthesis ammonium cyanate, to continue a study of cyanates which he had been carrying out for several years. On treating silver cyanate with ammonium chloride solution he obtained a white crystalline material which proved identical to urea obtained from urine.
AgNCO + NH4Cl → (NH2)2CO + AgCl
Synthetic urea is created from synthetic ammonia and carbon dioxide and can be produced as a liquid or a solid. The process of dehydrating ammonium carbamate under conditions of high heat and pressure to produce urea was first implemented in 1870 and is still in use today. Uses of synthetic urea are numerous and therefore production is high. Approximately one million pounds of urea is manufactured in the United States alone each year, most of it used in fertilizers. Nitrogen in urea makes it water soluble, a highly desired property in this application.
History
Urea has the distinction of being the first synthesized organic compound. Until the mid-18th century, scientists believed organic compounds came only from live plants and animals. The first serious blow to the theory of vitalism, which marked the beginning of modern organic chemistry, occurred when Friedrich W?hler (1800 1882) synthesized urea from the two inorganic substances, lead cyanate and ammonium hydroxide: Pb(OCN)2 + 2NH4OH→2(NH2)2CO + Pb(OH)2. W?hler's discoveries on urea occurred while he was studying cyanates; he was attempting to synthesize ammonium cyanate when he discovered crystals of urea in his samples. He first prepared urea in 1824, but he did not identify this product and report his findings until 1828. W?hler's synthesis of urea signaled the birth of organic chemistry.
Productions
The primary raw material used to manufacture urea is natural gas, which ties the costs directly to gas prices. Consequently, new plants are only being built in areas with large natural gas reserves where prices are lower. Finished product is transported around the globe in large shipments of 30,000 metric tons. The market price for urea is directly related to the world price of natural gas and the demand for agricultural products. Prices can be very volatile, and at times, unpredictable. TCC is positioned to know the world markets and keep your prices competitive.
Annual production of sulfuric acid
▼▲
World
164 million tonnes
China
62 million tonnes
India
23 million tonnes
Middle East
20 million tonnes
Rest of Asia
18 million tonnes
FSU
12 million tonnes
North America
9.5 million tonnes
Europe
9.5 million tonnes
It is expected that the global annual production will increase to over 200 million tonnes by 2018.
1. Potash Corporation, 2013
2. International Fertilizer Industry Association, 2014
Production methods
Historical process
Urea was first noticed by Hermann Boerhaave in the early 18th century from evaporates of urine. In 1773, Hilaire Rouelle obtained crystals containing urea from human urine by evaporating it and treating it with alcohol in successive filtrations. This method was aided by Carl Wilhelm Scheele's discovery that urine treated by concentrated nitric acid precipitated crystals. Antoine Fran?ois, comte de Fourcroy and Louis Nicolas Vauquelin discovered in 1799 that the nitrated crystals were identical to Rouelle's substance and invented the term "urea." Berzelius made further improvements to its purificationand finally William Prout, in 1817, succeeded in obtaining and determining the chemical composition of the pure substance. In the evolved procedure, urea was precipitated as urea nitrate by adding strong nitric acid to urine. To purify the resulting crystals, they were dissolved in boiling water with charcoal and filtered. After cooling, pure crystals of urea nitrate form. To reconstitute the urea from the nitrate, the crystals are dissolved in warm water, and barium carbonate added. The water is then evaporated and anhydrous alcohol added to extract the urea. This solution is drained off and evaporated, leaving pure urea.
Industrial process
For use in industry, urea is produced from synthetic ammonia and carbon dioxide. As large quantities of carbon dioxide are produced during the ammonia manufacturing process as a byproduct from hydrocarbons (predominantly natural gas, less often petroleum derivatives), or occasionally from coal, urea production plants are almost always located adjacent to the site where the ammonia is manufactured.
Urea can be produced as prills, granules, pellets, crystals, and solutions. The prills are formed by spraying molten urea down a tower up which air is pumped. They are slightly smaller than urea sold as granules and are particularly useful when the fertilizer is being applied by hand. In admixture, the combined solubility of ammonium nitrate and urea is so much higher than that of either component alone that it is possible to obtain a stable solution (known as UAN) with a total nitrogen content (32%) approaching that of solid ammonium nitrate (33.5%), though not, of course, that of urea itself (46%).
Fig.3 Industrial process of urea
Fig.4 An aerial view of a large plant in Alberta, Canada, in which ammonia is synthesized and then converted to urea.( By kind permission of Agrium Inc.)
Fig.5 Prills(small spheres of urea)
Fig.6 UAN(admixture of urea and ammonium nitrate)
Laboratory process
Ureas in the more general sense can be accessed in the laboratory by reaction of phosgene with primary or secondary amines, proceeding through an isocyanate intermediate. Non-symmetric ureas can be accessed by reaction of primary or secondary amines with an isocyanate.
Also, urea is produced when phosgene reacts with ammonia:
COCl2 + 4 NH3 → (NH2)2CO + 2 NH4Cl
Urea is byproduct of converting alkyl halides to thiols via a S-alkylation of thiourea. Such reactions proceed via the intermediacy of isothiouronium salts:
RX + CS(NH2)2 → RSCX(NH2)2X
RSCX(NH2)2X + MOH → RSH + (NH2)2CO + MX
In this reaction R is alkyl group, X is halogen and M is alkali metal.
Hazards
Health hazards
Inhalation:?
Causes irritation to the respiratory tract. Symptoms may include coughing, shortness of breath. May be absorbed into the bloodstream with symptoms similar to ingestion.?
Ingestion:?
Causes irritation to the gastrointestinal tract. Symptoms may include nausea, vomiting and diarrhea. May also cause headache, confusion and electrolyte depletion.?
Skin Contact:?
Causes irritation to skin. Symptoms include redness, itching, and pain.?
Eye Contact:?
Causes irritation, redness, and pain.?
Chronic Exposure:?
A study of 67 workers in an environment with high airborne concentrations of urea found a high incidence of protein metabolism disturbances, moderate emphysema, and chronic weight loss.?
Aggravation of Pre-existing Conditions:?
Supersensitive individuals with skin or eye problems, kidney impairment or asthmatic condition should have physician's approval before exposure to urea dust.
Fire Hazards
Behavior in Fire: Melting and decomposing to generate ammonia.
Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.
https://pubchem.ncbi.nlm.nih.gov/compound/urea#section=EPA-Safer-Chemical
Handling and Storage
Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect against physical damage. Isolate from incompatible substances. Containers of this material may be hazardous when empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the product.
Reference
https://en.wikipedia.org/wiki/Urea#Explosives
https://www.lookchem.com/ProductChemicalPropertiesCB5853861_EN.htm
https://chemistry.stackexchange.com/questions/54387/extracting-urea-from-urine/60338#60338
http://www.chm.bris.ac.uk/motm/urea/urea.html?
https://thechemco.com/chemical/urea/ ?
file:///C:/Users/zl/Desktop/kurzer1956.pdf
https://www.britannica.com/science/urea?
http://www.expertsmind.com/topic/biochemistry/urea-cycle-96120.aspx
http://sesl.com.au/blog/what-is-urea/?
http://www.essentialchemicalindustry.org/chemicals/urea.html?
http://www.atmos.umd.edu/~russ/MSDS/urea.htm
Production Methods
Urea is an important industrial compound. The synthesis of urea was discovered in 1870.Commercial production of urea involves the reaction of carbon dioxide and ammonia at highpressure and temperature to produce ammonium carbamate. Ammonium carbamate is thendehydrated to produce urea (Figure 96.1). The reaction uses a molar ratio of ammonia tocarbon dioxide that is approximately 3:1 and is carried out at pressures of approximately 150atmospheres and temperatures of approximately 180°C.
Indications
Urea-containing preparations have a softening and moisturizing effect on the stratum
corneum and, at times, may provide good therapy for dry skin and the pruritus
associated with it. They appear to have an antipruritic effect apart from their hydrating
qualities. Urea compounds disrupt the normal hydrogen bonds of epidermal
proteins; therefore, their effect in dry hyperkeratotic diseases such as ichthyosis
vulgaris and psoriasis is not only to make the skin more pliable but also to help
remove adherent scales. Lactic acid also has a softening and moisturizing effect on
the stratum corneum.Urea 40% ointment may be useful in removing hypertrophic or dystrophic
psoriatic nails. Subsequent topical therapy to the denuded nail bed and proximal
nail fold may result in regrowth of ‘‘normal’’ nails in half of those treated.
Preparation
All current processes for the manufacture of urea are based on the reaction of
ammonia and carbon dioxide to form ammonium carbamate which is
simultaneously dehydrated to urea:
The dehydration of ammonium carbamate is appreciable only at temperatures
above the melting point (about 150°C) and this reaction can only
proceed if the combined partial pressure of ammonia and carbon dioxide
exceeds the dissociation pressure of the ammonium carbamate (about
10 MPa at 160°C and about 30 MPa at 200°C). Thus commercial processes
are operated in the liquid phase at 160-220°C and 18-35 MPa (180-350
atmospheres). Generally, a stoichiometric excess of ammonia is employed,
molar ratios of up to 6: 1 being used. The dehydration of ammonium
carbamate to urea proceeds to about 50-65% in most processes. The reactor
effluent therefore consists of urea, water, ammonium carbamate and the
excess of ammonia. Various techniques are used for separating the components.
In one process the effluent is let down in pressure and heated at about
155°C to decompose the carbamate into ammonia and carbon dioxide. The
gases are removed and cooled. All the carbon dioxide present reacts with the
stoichiometric amount of ammonia to re-form carbamate, which is then
dissolved in a small quantity of water and returned to the reactor. The
remaining ammonia is liquefied and recycled to the reactor. Fresh make-up
ammonia and carbon dioxide are also introduced into the reactor. Removal of
ammonium carbamate and ammonia from the reactor effluent leaves an
aqueous solution of urea. The solution is partially evaporated and then urea is
isolated by recrystallization. Ammonium carbamate is very corrosive and at one time it was necessary to use silver-lined equipment but now satisfactory
alloy steel plant is available.
Biological Functions
The use of urea (Ureaphil, Urevert) has declined in
recent years owing both to its disagreeable taste and to
the increasing use of mannitol for the same purposes.
When used to reduce cerebrospinal fluid pressure, urea
is generally given by intravenous drip. Because of its potential
to expand the extracellular fluid volume, urea is
contraindicated in patients with severe impairment of
renal, hepatic, or cardiac function or active intracranial
bleeding.
Air & Water Reactions
Water soluble.
Reactivity Profile
Urea is a weak base. Reacts with hypochlorites to form nitrogen trichloride which explodes spontaneously in air [J. Am. Chem. Soc. 63:3530-32]. Same is true for phosphorus pentachloride. Urea reacts with azo and diazo compounds to generate toxic gases. Reacts with strong reducing agents to form flammable gases (hydrogen). The heating of improper stoichiometric amounts of Urea and sodium nitrite lead to an explosion. Heated mixtures of oxalic acid and Urea yielded rapid evolution of gases, carbon dioxide, carbon monoxide and ammonia (if hot, can be explosive). Titanium tetrachloride and Urea slowly formed a complex during 6 weeks at 80°C., decomposed violently at 90°C., [Chem. Abs., 1966, 64, 9219b]. Urea ignites spontaneously on stirring with nitrosyl perchlorate, (due to the formation of the diazonium perchlorate). Oxalic acid and Urea react at high temperatures to form toxic and flammable ammonia and carbon monoxide gasses, and inert CO2 gas [Von Bentzinger, R. et al., Praxis Naturwiss. Chem., 1987, 36(8), 41-42].
Health Hazard
May irritate eyes.
Fire Hazard
Behavior in Fire: Melts and decomposes, generating ammonia.
Trade name
PRESPERSION, 75 UREA?; SUPERCEL
3000?; UREAPHIL?; UREOPHIL?; UREVERT?;
VARIOFORM II?
Biochem/physiol Actions
Urea solution is primarily used for protein denaturation. It also increases solubility of hydrocarbons and reduce micelle formation. Urea solution at high concentration leads to the destabilization of amyloid β16?22 oligomers.
Safety Profile
Moderately toxic by
intravenous and subcutaneous routes.
Human reproductive effects by
intraplacental route: ferthty effects.
Experimental reproductive effects. Human
mutation data reported. A human skin
irritant. Questionable carcinogen with
experimental carcinogenic and
neoplastigenic data. Reacts with sodium
hypochlorite or calcium hypochlorite to
form the explosive nitrogen trichloride.
Incompatible with NaNO2, P2Cl5, nitrosyl
perchlorate. Preparation of the 15N-labeled
urea is hazardous. When heated to
decomposition it emits toxic fumes of NOx.
Potential Exposure
Urea is used in ceramics, cosmetics,
paper processing; resins, adhesives, in animal feeds; in the
manufacture of isocyanurates; resins, and plastics; as a stabilizer
in explosives; in medicines; anticholelithogenic, and
others.
Environmental Fate
Terrestrial Fate
Urea is expected to have very high mobility in soil. Urea is not
expected to volatilize from dry soil surfaces based on its vapor
pressure. Various field and laboratory studies have demonstrated
that urea degrades rapidly in most soils. Urea is rapidly hydrolyzed
to ammonium ions through soil urease activity, which
produces volatile gases, that is, ammonia and carbon dioxide.
However, the rate of hydrolysis can be much slower, depending
on the soil type, moisture content, and urea formulation.
Aquatic Fate
Urea is not expected to adsorb to suspended solids and sediments.
Volatilization from water surfaces is not expected. Urea
is rapidly hydrolyzed to ammonia and carbon dioxide in
environmental systems by the extracellular enzyme urease,
which originates from microorganisms and plant roots.
Atmospheric Fate
According to a model of gas/particle partitioning of semivolatile
organic compounds in the atmosphere, urea, which has
a vapor pressure of 1.2×10-5mm Hg at 251°C, will exist in
both the vapor and particulate phases in the ambient atmosphere.
Vapor-phase urea is degraded in the atmosphere by
reaction with photochemically produced hydroxyl radicals; the
half-life for this reaction in air is estimated to be 9.6 days.
Metabolism
The high analysis and good handling properties of urea
have made it the leading nitrogen fertilizer, both as
a source of nitrogen alone or when compounded with
other materials in mixed fertilizers. Although an excellent
source of nitrogen, urea can present problems unless
properly managed; due to its rapid hydrolysis to ammonia,
significant volatilization loss of this may occur if prilled
or granular urea is applied to and left on the soil
surface without timely incorporation. Mixtures of urea
and ammonium nitrate for use in mixed fertilizers are also
more highly hygroscopic than ammonium nitrate itself.
Purification Methods
Crystallise urea twice from conductivity water using centrifugal drainage and keeping the temperature below 60o. The crystals are dried under vacuum at 55o for 6hours. Levy and Margouls [J Am Chem Soc 84 1345 1962] prepared a 9M solution in conductivity water (keeping the temperature below 25o) and, after filtering through a medium-porosity glass sinter, added an equal volume of absolute EtOH. The mixture was set aside at -27o for 2-3 days and filtered cold. The precipitate was washed with a small amount of EtOH and dried in air. Crystallisation from 70% EtOH between 40o and -9o has also been used. Ionic impurities such as ammonium isocyanate have been removed by treating the concentrated aqueous solution at 50o with Amberlite MB-1 cation-and anion-exchange resin, and allowing it to crystallise on evaporation. [Benesch et al. J Biol Chem 216 663 1955.] It can also be crystallised from MeOH or EtOH, and is dried under vacuum at room temperature. [Beilstein 3 H 42, 3 I 19, 3 II 35, 3 III 80.]
Toxicity evaluation
The primary mechanism of toxicity appears to be inhibition of
the citric acid cycle. It leads to blockade of electron transport
and a decrease in energy production and cellular respiration,
which leads to convulsions.
Incompatibilities
Violent reaction with strong oxidizers,
chlorine, permanganates, dichromates, nitrites, inorganic
chlorides; chlorites, and perchlorates. Contact with hypochlorites
can result in the formation of explosive compounds.
Waste Disposal
Controlled incineration in
equipment containing a scrubber or thermal unit to reduce
nitrogen oxide emissions.
Check Digit Verification of cas no
The CAS Registry Mumber 57-13-6 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 7 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 57-13:
(4*5)+(3*7)+(2*1)+(1*3)=46
46 % 10 = 6
So 57-13-6 is a valid CAS Registry Number.
InChI:InChI=1/CH4N2O/c2-1(3)4/h(H4,2,3,4)
57-13-6Relevant articles and documents
Real-Time in Vivo Detection of H2O2 Using Hyperpolarized 13C-Thiourea
Wibowo, Arif,Park, Jae Mo,Liu, Shie-Chau,Khosla, Chaitan,Spielman, Daniel M.
, p. 1737 - 1742 (2017)
Reactive oxygen species (ROS) are essential cellular metabolites widely implicated in many diseases including cancer, inflammation, and cardiovascular and neurodegenerative disorders. Yet, ROS signaling remains poorly understood, and their measurements are a challenge due to high reactivity and instability. Here, we report the development of 13C-thiourea as a probe to detect and measure H2O2 dynamics with high sensitivity and spatiotemporal resolution using hyperpolarized 13C magnetic resonance spectroscopic imaging. In particular, we show 13C-thiourea to be highly polarizable and to possess a long spin-lattice relaxation time (T1), which enables real-time monitoring of ROS-mediated transformation. We also demonstrate that 13C-thiourea reacts readily with H2O2 to give chemically distinguishable products in vitro and validate their detection in vivo in a mouse liver. This study suggests that 13C-thiourea is a promising agent for noninvasive detection of H2O2 in vivo. More broadly, our findings outline a viable clinical application for H2O2 detection in patients with a range of diseases.
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Walker,Kay
, p. 489 (1897)
-
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Surrey,Nachod
, p. 2336 (1951)
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Evidence for an inhibitory LIM domain in a rat brain agmatinase-like protein
Castro, Victor,Fuentealba, Pablo,Henriquez, Adolfo,Vallejos, Alejandro,Benitez, Jose,Lobos, Marcela,Diaz, Beatriz,Carvajal, Nelson,Uribe, Elena
, p. 107 - 110 (2011)
We recently cloned a rat brain agmatinase-like protein (ALP) whose amino acid sequence greatly differs from other agmatinases and exhibits a LIM-like domain close to its carboxyl terminus. The protein was immunohistochemically detected in the hypothalamic region and hippocampal astrocytes and neurons. We now show that truncated species, lacking the LIM-type domain, retains the dimeric structure of the wild-type protein but exhibits a 10-fold increased kcat, a 3-fold decreased Km value for agmatine and altered intrinsic tryptophan fluorescent properties. As expected for a LIM protein, zinc was detected only in the wild-type ALP (~2 Zn2+/monomer). Our proposal is that the LIM domain functions as an autoinhibitory entity and that inhibition is reversed by interaction of the domain with some yet undefined brain protein.
Wyatt,Kornberg
, p. 454,458 (1952)
Aminoguanidinium hydrolysis effected by a hydroxo-bridged Dicobalt(II) complex as a functional model for arginase and catalyzed by mononuclear Cobalt(II) complexes
He, Chuan,Lippard, Stephen J.
, p. 105 - 113 (1998)
The dinuclear complex [Co2(μ-OH)(μ-XDK)(bpy)2(EtOH)](NO3), where XDK is the dinucleating dicarboxylate ligand m-xylylenediamine bis(Kemp's triacid imide) and bpy = 2,2'-bipyridine, was prepared as a functional model for arginase. The substrate aminoguanidinium nitrate was hydrolyzed to urea in ethanol by the complex but not by free hydroxide ion under the same conditions. The amino group of the substrate binds to cobalt, as demonstrated by W-vis spectroscopic studies. The syntheses of related dinuclear cobalt(II) complexes [Co2(μ-XDK)(NO3)2(CH3OH)2(H2O)], [Co2(μ-Cl)(μ-XDK)(bpy)2(EtOH)2](NO3), and [Co2(μ-XDK)-(py)3(NO3)2] are described. Mononuclear complexes [Co(XDK)(bpy)(H2O)] and [Zn(XDK)(bpy)(H2O)] were also prepared and characterized. The former catalytically hydrolyzes aminoguanidinium nitrate to urea in basic 1:1 methanol/water solutions, whereas the latter does not promote this reaction. Hydrolysis of aminoguanidinium ion is effected by [Co(CH3COO)2] and [Cu(CH3COO)2] in the presence of bpy, but not by [Zn(CH3COO))2], [Ni(CH3COO)2], or [Mn(CH3COO)2] in the presence of bpy in 1:1 methanol/water solution. In all cases, coordination of the amino group of the substrate to the metal center under the reaction conditions may activate the leaving group and orient the guanidinium moiety close to the attacking nucleophile, metal-bound hydroxide ion, to promote the hydrolysis reaction.
Photocatalytic synthesis of urea from in situ generated ammonia and carbon dioxide
Srinivas, Basavaraju,Kumari, Valluri Durga,Sadanandam, Gullapelli,Hymavathi, Chilumula,Subrahmanyam, MacHiraju,De, Bhudev Ranjan
, p. 233 - 241 (2012)
TiO2 and Fe-titanate (different wt%) supported on zeolite were prepared by sol-gel and solid-state dispersion methods. The photocatalysts prepared were characterized by X-ray diffraction, scanning electron microscopy and ultraviolet (UV)-visible diffuse reflectance spectroscopy techniques. Photocatalytic reduction of nitrate in water and isopropanol/oxalic acid as hole scavengers are investigated in a batch reactor under UV illumination. The yield of urea increased notably when the catalysts were supported on zeolite. The Fe-titanate supported catalyst promotes the charge separation that contributes to an increase in selective formation of urea. The product formation is because of the high adsorption of in situ generated CO2 and NH3 over shape-selective property of the zeolite in the composite photocatalyst. The maximum yield of urea is found to be 18 ppm while 1% isopropanol containing solution over 10 wt% Fe-titanate/HZSM-5 photocatalyst was used.
Sullivan,Kilpatrick
, p. 1815,1820 (1945)
-
Clark,Gaddy,Rist
, p. 1092 (1933)
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Oxyhalogen-sulfur chemistry: Kinetics and mechanism of oxidation of formamidine disulfide by acidic bromate
Madhiri, Nicholas,Olojo, Rotimi,Simoyi, Reuben H.
, p. 4149 - 4156 (2003)
The kinetics and mechanism of the oxidation of formamidine disulfide, FDS, a dimer and major metabolite of thiourea, by bromate have been studied in acidic media. In excess bromate conditions the reaction displays an induction period before formation of bromine. The stoichiometry of the reaction is: 7BrO3- + 3[(H2N(HN=)CS-]2 + 9H 2O → 6NH2CONH2 + 6SO4 2- + 7Br- + 12H- (A). In excess oxidant conditions, however, the bromide formed in reaction A reacts with bromate to give bromine and a final stoichiometry of: 14BrO3- + 5[(H2N(HN=)CS-]2 + 8H2O → 10NH 2CONH2 + 10SO42- + 7Br2 + 6H+ (B). The direct reaction of bromine and FDS was also studied and its stoichiometry is: 7Br2 + [(H2N(HN=)CS-] 2 + 10H2O → 2NH2CONH2 + 2SO42- + 14Br- + 18H+ (C). The overall rate of reaction A, as measured by the rate of consumption of FDS, is second order in acid concentrations, indicating the dominance of oxyhalogen kinetics which control the formation of the reactive species HBrO2 and HOBr. The reaction proceeds through an initial cleavage of the S-S bond to give the unstable sulfenic acids which are then rapidly oxidized through the sulfinic and sulfonic acids to give sulfate. The formation of bromine coincides with formation of sulfate because the cleavage of the C-S bond to give sulfate occurs at the sulfonic acid stage only. The mechanism derived is the same as that derived for the bromate-thiourea reaction, suggesting that FDS is an intermediate in the oxidation of thiourea to its oxo-acids as well as to sulfate.
-
Palm,Calvin
, p. 2115 (1962)
-
-
Schwander,Cordebard
, (1930)
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Oxyhalogen-Sulfur Chemistry: The Bromate-(Amininoimino)methanesulfinic Acid Reaction in Acidic Medium
Chinake, Cordelia R.,Simoyi, Reuben H.,Jonnalagadda, Sreekantha B.
, p. 545 - 550 (1994)
The reaction between (amnoimino)methanesulfinic acid, HO2SC(NH)NH2(AIMSA), and bromate has been studied in acidic medium.In excess AIMSA the stoichiometry of the reaction is 2BrO3- + 3AIMSA + 3H2O -> 3SO42- + 3CO(NH2)2 + 2Br- + 6H+, and in excess bromate the stoichiometry is 4BrO3- + 5AIMSA + 3H2O -> 5SO42- + 5CO(NH2)2 + 2Br2 + 6H+.Br2 is produced only when BrO3- is in stoichiometric excess over AIMSA.It is produced from the reaction of the product, Br-, with excess BrO3- after all the AIMSA has been consumed.The reaction has an initial induction period followed by formation of bromine.Although AIMSA is oxidized to SO42-, no SO42- formation is observed until Br2 production commences.The reaction is autocatalyzed by bromide.The reactive oxidizing species in solution are HOBr and Br2.Bromide enhances their formation from bromate.A simple eight-reaction mechanism is used to describe the reaction.The reaction commences through a direct reaction between BrO3- and AIMSA: BrO3+ + HO2SC(NH)NH2 + H+ -> HBrO2 + HO3SC(NH)NH2 with k = 2.5E-2M-2s-1.The rate-determining step is the standard BrO3- - Br- reaction which forms the reactive species HOBr:BrO3- + Br- + 2H+ -> HBrO2 + HOBr.A computer simulation analysis of the proposed mechanism gave good fit to the data.
Spectroscopic study of photo and thermal destruction of riboflavin
Astanov, Salikh,Sharipov, Mirzo Z.,Fayzullaev, Askar R.,Kurtaliev, Eldar N.,Nizomov, Negmat
, p. 133 - 138 (2014)
Influence of temperature and light irradiation on the spectroscopic properties of aqueous solutions of riboflavin was studied using linear dichroism method, absorption and fluorescence spectroscopy. It was established that in a wide temperature range 290-423 K there is a decline of absorbance and fluorescence ability, which is explained by thermodestruction of riboflavin. It is shown that the proportion of molecules, which have undergone degradation, are in the range of 4-28%, and depends on the concentration and quantity of temperature effects. Introduction of hydrochloric and sulfuric acids, as well as different metal ions leads to an increase in the photostability of riboflavin solutions by 2-2.5 times. The observed phenomena are explained by the formation protonation form of riboflavin and a complex between the metal ions and oxygen atoms of the carbonyl group of riboflavin, respectively.
Cattaway, F. D.
, p. 170 (1912)
Formation of adenine from CH3COONH4/NH 4HCO3-the probable prebiotic route for adenine
Singh, Palwinder,Singh, Amrinder
, p. 2525 - 2527 (2013)
Adenine was formed when an aqueous solution of CH3COONH 4/NH4HCO3 was subjected to mass spectrometer/refluxed for 72 h/heated in a closed vessel for a long time. Since these salts are sources of CO2 and NH3 and H2O is available from the reaction medium, adenine might get formed by the combination of CO2, H2O and NH3. The occurrence of this reaction in the gas phase as well as in the aqueous phase points towards the possibility of similar reactions during the primitive earth conditions.
Decomposition of Thiourea Dioxide under Aerobic and Anaerobic Conditions in an Aqueous Alkaline Solution
Egorova, E. V.,Nikitin, K. S.,Polenov, Yu. V.
, p. 2038 - 2041 (2020)
Abstract: The kinetics and mechanism of the decomposition of thiourea dioxide in an aqueous alkaline solution under aerobic and anaerobic conditions are established. It is discovered that along with the decomposition of thiourea dioxide molecules with C–S bond cleavage and the subsequent formation of sulfoxyl acid anions, there is a reversible stage of the formation of thiourea and peroxide anions. The rate constants of the indicated stages are determined via mathematical modeling using the experimental data.
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Franz,Applegath
, p. 3304 (1961)
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Inoue et al.
, p. 1339,1344 (1972)
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Jaffe
, p. 398 (1890)
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Degradation of 2-ketoarginine by guanidinobutyrase in arginine aminotransferase pathway of Brevibacterium helvolum.
Yorifuji,Kaneoke,Okazaki,Shimizu
, p. 512 - 513 (1995)
Guanidinobutyrase (EC 3.5.3.7) involved in the arginine oxygenase pathway of Brevibacterium helvolum IFO 12073 was found to catalyze also the hydrolysis of 2-ketoarginine (2-keto-5-guanidinovalerate) to 2-ketoornithine (2-keto-5-aminovalerate) and urea, the second step of the arginine aminotransferase pathway. No other enzyme that degraded 2-ketoarginine was found in cells grown on L-arginine. The enzyme hydrolyzed 2-ketoarginine with a relative rate of about 0.7% of that toward 4-guanidinobutyrate. The Km for 2-ketoarginine was 33 mM.
Davis, T. L.,Blanchard, K. C.
, p. 1806 - 1810 (1929)
Datta, R. L.,Choudhury, J. K.
, p. 2736 - 2740 (1916)
Catalytic Urea Synthesis from Ammonium Carbamate Using a Copper(II) Complex: A Combined Experimental and Theoretical Study
Dennis, Donovan,Ekmekci, Merve B.,Hanson, Danielle S.,Paripati, Amay,Wang, Yigui,Washburn, Erik,Xiao, Dequan,Zhou, Meng,Zhou, Xinrui
, p. 5573 - 5589 (2021/05/06)
The synthesis of urea fertilizer is currently the largest CO2 conversion process by volume in the industry. In this process, ammonium carbamate is an intermediate en route to urea formation. We determined that the tetraammineaquacopper(II) sulfate complex, [Cu(NH3)4(OH2)]SO4, catalyzed the formation of urea from ammonium carbamate in an aqueous solution. A urea yield of up to 18 ± 6% was obtained at 120 °C after 15 h and in a high-pressure metal reactor. No significant urea formed without the catalyst. The urea product was characterized by Fourier transform infrared (FT-IR), powder X-ray diffraction (PXRD), and quantitative 1H{13C} NMR analyses. The [Cu(NH3)4(OH2)]SO4 catalyst was then recovered at the end of the reaction in a 29% recovery yield, as verified by FT-IR, PXRD, and quantitative UV-vis spectroscopy. A precipitation method using CO2 was developed to recover and reuse 66 ± 3% of Cu(II). The catalysis mechanism was investigated by the density functional theory at the B3LYP/6-31G*? level with an SMD continuum solvent model. We determined that the [Cu(NH3)4]2+ complex is likely an effective catalyst structure. The study of the catalysis mechanism suggests that the coordinated carbamate with [Cu(NH3)4]2+ is likely the starting point of the catalyzed reaction, and carbamic acid can be involved as a transient intermediate that facilitates the removal of an OH group. Our work has paved the way for the rational design of catalysts for urea synthesis from the greenhouse gas CO2.
Unveiling Electrochemical Urea Synthesis by Co-Activation of CO2 and N2 with Mott–Schottky Heterostructure Catalysts
Yuan, Menglei,Chen, Junwu,Bai, Yiling,Liu, Zhanjun,Zhang, Jingxian,Zhao, Tongkun,Wang, Qin,Li, Shuwei,He, Hongyan,Zhang, Guangjin
, p. 10910 - 10918 (2021/04/19)
Electrocatalytic C?N bond coupling to convert CO2 and N2 molecules into urea under ambient conditions is a promising alternative to harsh industrial processes. However, the adsorption and activation of inert gas molecules and then the driving of the C–N coupling reaction is energetically challenging. Herein, novel Mott–Schottky Bi-BiVO4 heterostructures are described that realize a remarkable urea yield rate of 5.91 mmol h?1 g?1 and a Faradaic efficiency of 12.55 % at ?0.4 V vs. RHE. Comprehensive analysis confirms the emerging space–charge region in the heterostructure interface not only facilitates the targeted adsorption and activation of CO2 and N2 molecules on the generated local nucleophilic and electrophilic regions, but also effectively suppresses CO poisoning and the formation of endothermic *NNH intermediates. This guarantees the desired exothermic coupling of *N=N* intermediates and generated CO to form the urea precursor, *NCON*.
Catalytic hydration of cyanamides with phosphinous acid-based ruthenium(ii) and osmium(ii) complexes: scope and mechanistic insights
álvarez, Daniel,Cadierno, Victorio,Crochet, Pascale,González-Fernández, Rebeca,López, Ramón,Menéndez, M. Isabel
, p. 4084 - 4098 (2020/07/09)
The synthesis of a large variety of ureas R1R2NC(O)NH2 (R1 and R2 = alkyl, aryl or H; 26 examples) was successfully accomplished by hydration of the corresponding cyanamides R1R2NCN using the phosphinous acid-based complexes [MCl2(η6-p-cymene)(PMe2OH)] (M = Ru (1), Os (2)) as catalysts. The reactions proceeded cleanly under mild conditions (40-70 °C), in the absence of any additive, employing low metal loadings (1 molpercent) and water as the sole solvent. In almost all the cases, the osmium complex 2 featured a superior reactivity in comparison to that of its ruthenium counterpart 1. In addition, for both catalysts, the reaction rates observed for the hydration of the cyanamide substrates were remarkably faster than those involving classical aliphatic and aromatic nitriles. Computational studies allowed us to rationalize all these trends. Thus, the calculations indicated that the presence of a nitrogen atom directly linked to the CN bond depopulates electronically the nitrile carbon by inductive effect when coordinated to the metal center, thus favouring the intramolecular nucleophilic attack of the OH group of the phosphinous acid ligand to this carbon. On the other hand, the higher reactivity of Os vs. Ru seems to be related with the lower ring strain on the incipient metallacycle that starts to form in the transition state associated with this key step in the catalytic cycle. Indirect experimental evidence of the generation of the metallacyclic intermediates was obtained by studying the reactivity of [RuCl2(η6-p-cymene)(PMe2OH)] (1) towards dimethylcyanamide in methanol and ethanol. The reactions afforded compounds [RuCl(η6-p-cymene)(PMe2OR)(NCNMe2)][SbF6] (R = Me (5a), Et (5b)), resulting from the alcoholysis of the metallacycle, which could be characterized by single-crystal X-ray diffraction. This journal is