57277-25-5

Basic information

• Product Name: Diethyl (2-naphtylmethyl)phosphonate
• Synonyms: Diethyl (2-naphtylmethyl)phosphonate;Diethyl (naphthalen-2-ylMethyl)phosphonate
• CAS NO: 57277-25-5
• Molecular Formula: C₁₅H₁₉O₃P
• Molecular Weight: 278.283321
• Mol File: 57277-25-5.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Diethyl (2-naphtylmethyl)phosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: Diethyl (2-naphtylmethyl)phosphonate(57277-25-5)
• EPA Substance Registry System: Diethyl (2-naphtylmethyl)phosphonate(57277-25-5)

Safety Data

• Hazardous Substances Data: 57277-25-5(Hazardous Substances Data)

Usage

General Description

Diethyl (2-naphtylmethyl)phosphonate is a chemical compound that belongs to the group of phosphonates, which are organic compounds containing a carbon-phosphorus bond. This particular compound is composed of two ethyl groups, a 2-naphthylmethyl group, and a phosphonate group. It is commonly used as a reagent in organic synthesis, particularly in the formation of carbon-phosphorus bonds. Diethyl (2-naphtylmethyl)phosphonate has also been studied for its potential biological and pharmaceutical applications, including as a precursor for the synthesis of medicinal drugs and as an inhibitor for certain enzymes. Additionally, it has been investigated for its potential use as a flame retardant and pesticide.

Upstream product

• 762-04-9 phosphonic acid diethyl ester 
• 939-26-4 2-bromomethylnaphthyl bromide 
• 1592-38-7 2-Naphthalenemethanol 
• 122-52-1 triethyl phosphite 
• 66-99-9 β-naphthaldehyde 
• 19350-74-4 2-naphthaldehyde tosylhydrazone 
• 78-40-0 triethyl phosphate 
• 3167-63-3 diethyl chloromethylphosphonate 
• 580-13-2 2-bromonaphthalene 

Downstream Products

• 126479-93-4 9-benzenesulfonyl-3-(2-naphthylethenyl)carbazole 
• 1372151-85-3 C₂₂H₂₄FO₃P 
• 16672-84-7 2-Naphthylmethylphosphonic acid 

Relevant articles and documents

The development of HEC-866 and its analogues for the treatment of idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with a typical survival time between three to five years. Two drugs, pirfenidone and nintedanib have been approved for the treatment of IPF, but they have limited efficacy. Thus, th

Oxidative Dephosphorylation of Benzylic Phosphonates with Dioxygen Generating Symmetrical trans-Stilbenes

Under a dioxygen atmosphere, benzylphosphonates and related phosphoryl compounds can readily produce the corresponding trans-stilbenes in high yields with high selectivity upon treatment with bases. Various functional groups were tolerable under the reaction conditions.

Synthetic method for alkyl group phosphorous acid diester compounds or alkyl group phosphinic acid ester compounds

The invention discloses a synthetic method for alkyl group phosphorous acid diester compounds or alkyl group phosphinic acid ester compounds. According to the synthetic method, alcohols which are cheap, easy to get, wide in source, stable and low in toxicity serve as alkylating reagents, iodine salt which is cheap and easy to get serves as catalysts, no solvent is needed, and the alkyl group phosphorous acid diester compounds can be selectively directly obtained after a reaction. The reaction method is simple, the condition is mild, no organic solvent is needed and operation is simple. According to the method, the requirements for reaction conditions are low, various types of alcohols such as a benzyl group type, an allyl type and a fat type can be utilized as the alkylate reagents to implement the synthesis of different types of substituted alkyl group phosphorous acid diester, and the method can be further expanded to the synthesis of the alkyl group phosphinic acid ester compounds through the reaction between the substituted phosphonous acid diester and the alcohols.