58550-50-8

Basic information

• Product Name: benzoic acid-[3]pyridylmethyl ester
• Synonyms: benzoic acid-[3]pyridylmethyl ester
• CAS NO: 58550-50-8
• Molecular Formula: C₁₃H₁₁NO₂
• Molecular Weight: 213
• Mol File: 58550-50-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: benzoic acid-[3]pyridylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: benzoic acid-[3]pyridylmethyl ester(58550-50-8)
• EPA Substance Registry System: benzoic acid-[3]pyridylmethyl ester(58550-50-8)

Safety Data

• Hazardous Substances Data: 58550-50-8(Hazardous Substances Data)

Upstream product

• 100-55-0 3-hydroxymethylpyridin 
• 98-88-4 benzoyl chloride 
• 106344-89-2 3-nitroso-1-phenyl-3-(3-pyridylmethyl)urea 
• 65-85-0 benzoic acid 
• 500-22-1 3-pyridinecarboxaldehyde 
• 611-74-5 N,N-dimethylbenzamide 
• 99802-96-7 2-benzoyl-1,3-dimethyl-1H-imidazol-3-ium iodide 
• 30148-17-5 (1-methyl-1H-imidazol-2-yl)(phenyl)methanone 
• 85909-02-0 N-benzyl-N-(tert-butoxycarbonyl)-benzamide 
• 120-46-7 1,3-diphenylpropanedione 
• 5433-39-6 N'-nicotinoylbenzenesulfonohydrazide 
• 553-53-7 Nicotinic acid hydrazide 
• 53101-95-4 1-phenyl-3-pyridin-3-ylmethylurea 

Downstream Products

• 66310-17-6 3-benzoyloxymethyl-1-methyl-pyridinium; iodide 
• 108-99-6 3-Methylpyridine 

Relevant articles and documents

Hydrogen-bond-assisted transition-metal-free catalytic transformation of amides to esters

The amide C-N cleavage has drawn a broad interest in synthetic chemistry, biological process and pharmaceutical industry. Transition-metal, luxury ligand or excess base were always vital to the transformation. Here, we developed a transition-metal-free hydrogen-bond-assisted esterification of amides with only catalytic amount of base. The proposed crucial role of hydrogen bonding for assisting esterification was supported by control experiments, density functional theory (DFT) calculations and kinetic studies. Besides broad substrate scopes and excellent functional groups tolerance, this base-catalyzed protocol complements the conventional transition-metal-catalyzed esterification of amides and provides a new pathway to catalytic cleavage of amide C-N bonds for organic synthesis and pharmaceutical industry. [Figure not available: see fulltext.]

Esterification of Tertiary Amides by Alcohols Through C?N Bond Cleavage over CeO2

CeO2 has been found to promote ester forming alcoholysis reactions of tertiary amides. The present catalytic system is operationally simple, recyclable, and it does not require additives. The esterification process displays a wide substrate scope (>45 examples; up to 93 % isolated yield). Results of a density functional theory (DFT) study combined with in situ FT-IR observations indicate that the process proceeds through rate limiting addition of a CeO2 lattice oxygen to the carbonyl group of the adsorbed acetamide species with energy barrier of 17.0 kcal/mol. This value matches well with experimental value (17.9 kcal/mol) obtained from analysis of the Arrhenius plot. Further studies by in situ FT-IR and temperature programmed desorption using probe molecules demonstrate that both acidic and basic properties are important, and consequently, CeO2 showed the best performance for the C?N bond cleavage reaction.

Nitrosation of 1-phenyl-3-(pyridylmethyl)ureas and the reactivity of two nitrosated isomers

-