59656-60-9

Basic information

• Product Name: N-(4-(pyridin-4-yl)phenyl)acetamide
• Synonyms: N-(4-(pyridin-4-yl)phenyl)acetamide
• CAS NO: 59656-60-9
• Molecular Weight: 212.251
• Mol File: 59656-60-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: N-(4-(pyridin-4-yl)phenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-(pyridin-4-yl)phenyl)acetamide(59656-60-9)
• EPA Substance Registry System: N-(4-(pyridin-4-yl)phenyl)acetamide(59656-60-9)

Safety Data

• Hazardous Substances Data: 59656-60-9(Hazardous Substances Data)

Upstream product

• 13296-04-3 4-(pyridin-4-yl)aniline 
• 19524-06-2 4-bromopyridine hydrochloride 
• 214360-60-8 N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide 
• 103-88-8 4-bromoacetanilide 
• 1692-15-5 4-pyridylboronic acid 
• 106-40-1 4-bromo-aniline 
• 25108-37-6 potassium pyridine-4-carboxylate 
• 622-50-4 4-Acetamido-1-iodobenzene 
• 113964-72-0 triphenyl(pyridin-4-yl)phosphonium trifluoromethanesulfonate 

Downstream Products

• 668435-29-8 N-(4-(1-methylpiperidin-4-yl)phenyl)acetamide 
• 668435-32-3 N-(4-(1-methylpiperidin-4-yl)-2-nitrophenyl)acetamide 
• 147293-18-3 2-bromo-4-(4-pyridinyl)benzenamine 
• 668423-23-2 4-(1-methylpiperidin-4-yl)-2-nitroaniline 
• 13296-04-3 4-(pyridin-4-yl)aniline 
• 1360452-74-9 C₁₅H₁₇N₂O⁽¹⁺⁾ 
• 861024-61-5 4-([1,1’-biphenyl]-4-yl)pyridine 

Relevant articles and documents

Palladium-Catalyzed Electrophilic Functionalization of Pyridine Derivatives through Phosphonium Salts

Herein, we report a highly efficient and practical method for pyridine-derived heterobiaryl synthesis through palladium-catalyzed electrophilic functionalization of easily available pyridine-derived quaternary phosphonium salts. The nice generality of this reaction was goes beyond arylation, enabling facile incorporation of diverse carbon-based fragments, including alkenyl, alkynyl, and also allyl fragments, onto the pyridine core. Notably, the silver salt additive is revealed to be of vital importance for the success of this transformation and its pivotal role as transmetallation mediator, which guarantees a smooth transfer of pyridyl group to palladium intermediate, is also described.

ARYL AMIDE KINASE INHIBITORS

The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

N-aryl-2-aminobenzimidazoles: Novel, efficacious, antimalarial lead compounds

From the phenotypic screening of the AstraZeneca corporate compound collection, N-aryl-2-aminobenzimidazoles have emerged as novel hits against the asexual blood stage of Plasmodium falciparum (Pf). Medicinal chemistry optimization of the potency against Pf and ADME properties resulted in the identification of 12 as a lead molecule. Compound 12 was efficacious in the P. berghei (Pb) model of malaria. This compound displayed an excellent pharmacokinetic profile with a long half-life (19 h) in rat blood. This profile led to an extended survival of animals for over 30 days following a dose of 50 mg/kg in the Pb malaria model. Compound 12 retains its potency against a panel of Pf isolates with known mechanisms of resistance. The fast killing observed in the in vitro parasite reduction ratio (PRR) assay coupled with the extended survival highlights the promise of this novel chemical class for the treatment of malaria.