59768-70-6Relevant articles and documents
PROCESS FOR PREPARATION OF (IS, 3S, 5S)-2-[(2S)-2-AMIN0-2-(3-HYDROXY-l-ADAMANTYL) ACETYL]-2-AZABICYCLO [3.1.0] HEXANE-3-CARBONITRILE
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Paragraph 0048, (2015/04/28)
Provided are novel processes for the preparation of Saxagliptin and novel intermediates employed in the process for preparing Saxagliptin.
Copper-catalyzed synthesis of azaspirocyclohexadienones from ∝-azido- N -arylamides under an oxygen atmosphere
Chiba, Shunsuke,Zhang, Line,Lee, Jian-Yuan
supporting information; experimental part, p. 7266 - 7267 (2010/08/05)
A copper-catalyzed reaction of ∝-azido-N-arylamides was found to proceed under an oxygen atmosphere to afford azaspirocyclohexadienones. The present transformation is carried out by a sequence of denitrogenative formation of iminyl copper species from ∝-azido-N-arylamides and their imino-cupration with an intramolecular benzene ring on the amido nitrogen followed by consecutive formation of C-O bonds. The preliminary investigation revealed that molecular oxygen is a prerequisite for achieving the present catalytic cyclization and that one of the oxygen atoms of O2 was found to be incorporated into the cyclohexadienone moiety.
α-AMINO ACIDS OF THE ADAMANTANE SERIES. III. DEAMINATION AS A METHOD FOR THE SYNTHESIS OF HOMOADAMANTANE DERIVATIVES
Krasutskii, P. A.,Semenova, I. G.,Safronova, E. E.,Novikova, M. I.,Yurchenko, A. G.
, p. 2106 - 2111 (2007/10/02)
The deamination of 1-adamantylglycine and its methyl-substituted analogs in acetic, trifluoroacetic, and sulfuric acids was investigated for the first time.The optimum conditions for the selective conversion of α-amino acids of the adamantane series into the β-hydroxy acids of homoadamantane are the conditions of solvolysis by the action of sodium nitrite in 70percent sulfuric acid.The synthetic transformations of 3-hydroxyhomoadamantane-4-carboxylic acid have opened up the way to the synthesis of new 3,4-disubstituted homoadamantanes.
