602295-91-0Relevant articles and documents
Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore
Zhi, Lin,Ringgenberg, Josef D.,Edwards, James P.,Tegley, Christopher M.,West, Sarah J.,Pio, Barbara,Motamedi, Mehrnouch,Jones, Todd K.,Marschke, Keith B.,Mais, Dale E.,Schrader, William T.
, p. 2075 - 2078 (2003)
A series of 1,2-dihydrochromeno[3,4-f]quinoline derivatives was synthesized and tested in biological assays to evaluate the nonsteroidal progesterone receptor modulator pharmacophore (4) as antiprogestins. A number of potent analogues were identified by modification of the substituents at the D-ring.
