607-57-8 Usage
Description
2-Nitrofluorene is a chemical compound that contains a nitro group attached to a fluorene molecule. It is known for its genotoxic properties, meaning it can cause damage to the DNA of living organisms, and is considered an environmental pollutant.
Uses
Used in Environmental Monitoring:
2-Nitrofluorene is used as a biomarker for assessing the presence of environmental pollutants, particularly in areas where industrial activities may release genotoxic compounds into the environment. Its detection can help identify contamination and monitor the effectiveness of pollution control measures.
Used in Research and Development:
2-Nitrofluorene is utilized in scientific research as a model genotoxic compound to study the mechanisms of DNA damage and repair, as well as to develop and test new methods for detecting and mitigating genotoxic substances. This research can contribute to a better understanding of the effects of environmental pollutants on human health and the environment.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Aromatic nitro compounds, such as 2-Nitrofluorene, range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents. The explosive tendencies of aromatic nitro compounds are increased by the presence of multiple nitro groups. Stable under normal conditions. Protect from bases.
Health Hazard
ACUTE/CHRONIC HAZARDS: Toxic. Hazardous decomposition products. Carcinogen.
Safety Profile
Confirmed carcinogen
with experimental carcinogenic and
tumorigenic data. Moderately toxic by
intraperitoneal route. Human mutation data
reported. When heated to decomposition it
emits toxic fumes of NOx. See also NITRO
COMPOUNDS OF AROMATIC
HYDROCARBONS.
Metabolic pathway
Lung microsomal metabolism of 2-nitrofluorene (NF)
increases in parallel with the accumulation of P-450b
homologous mRNA and microsomal cytochrome P-
450b protein concentration. The formation of the major
metabolite, and potent mutagen, 9-hydroxy-2-
nitrofluorene (9-OHNF) is significantly inhibited by the
addition of polyclonal anti-P-450b-IgG, and by the
addition of the inhibitor, proadifen, to incubations with
lung microsomal protein.
Purification Methods
Crystallise 2-nitrofluorene from aqueous acetic acid or Me2CO (m 158-158.5o, also 160-160.5o). [Beilstein 5 H 628, 5 III 1948.]
Check Digit Verification of cas no
The CAS Registry Mumber 607-57-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,0 and 7 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 607-57:
(5*6)+(4*0)+(3*7)+(2*5)+(1*7)=68
68 % 10 = 8
So 607-57-8 is a valid CAS Registry Number.
InChI:InChI=1/C13H9NO2/c15-14(16)11-5-6-13-10(8-11)7-9-3-1-2-4-12(9)13/h1-6,8H,7H2
607-57-8Relevant articles and documents
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Weisburger,Weisburger
, p. 1396,1399 (1955)
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Microwave-induced surface-mediated highly efficient regioselective nitration of aromatic compounds: Effects of penetration depth
BANIK, BIMAL K.,DAS, APARNA,YADAV, RAM NARESH
, p. 2203 - 2206 (2021/08/24)
Surface mediated highly regioselective nitration of aromatic compounds under diverse microwave-induced conditions was investigated in this work. The effects of the penetration depth of the surfaces were found to be more crucial than other dielectric parameters. Despite significant progress of microwave-induced reactions, no reports have examined the penetration depth of the surfaces used in these processes.
Comparative analysis to explore the suitability of a short chain dyad in its pristine and nanocomposite forms for designing artificial light energy conversion device
Paul, Somnath,Mitra, Ishani,Dutta, Rituparna,Bardhan, Munmun,Bose, Mridul,Das, Subrata,Saha, Mithu,Ganguly, Tapan
, p. 7873 - 7881 (2018/09/06)
From the UV-vis, steady state and time resolved spectroscopic investigations on the pristine dyad, dyad-spherical gold nanoparticles (GNP) and dyad-star shaped gold nanoparticles (GNS), it was observed that though in the ground state the dyad in its pristine form possesses trans-type (elongated and planar) isomer but on photoexcitation trans-form converts into cis-structure (folded). Interestingly, the dyad exhibits different behavior when it combines with GNP or GNS. In nanocomposite form, even on photoexcitation some ground state trans-structure still retains its identity in the excited state. The 60% of the trans-species remains unchanged in the excited state due to excitation of dyad-GNS system and possibly this configuration facilitates the hindrance of energy destructive charge recombination processes as in this conformer the donor and acceptor moieties tend to move far away from each other causing lack of overlapping of charge clouds within the two redox components. The dyad-GNS nanocomposite appears to be the best possible light energy conversion or storage device within the three system studied in the present investigation. Investigations are underway to examine how the degree of surface coverage of the dyad on the surface of gold nanoparticles affect its geometry or conformational changes on photoexcitation.