610-35-5

Basic information

• Product Name: 4-Hydroxyphthalic acid
• Synonyms: RARECHEM AL BO 0808;4-hydroxy-2-benzenedicarboxylicacid;AKOS 237-77;4-HYDROXYPHTHALIC ACID;4-HYDROXY-1,2-BENZENEDICARBOXYLIC ACID;3,4-DICARBOXYPHENOL;4-hydroxy phthalic acid 4-HPA;4-Hydroxyphthalic acid,98%
• CAS NO: 610-35-5
• Molecular Formula: C₈H₆O₅
• Molecular Weight: 182.13
• EINECS: 210-221-6
• Product Categories: Phthalic Acids, Esters and Derivatives
• Mol File: 610-35-5.mol
• Article Data: 13

Chemical Properties

• Melting Point: 191-194 °C
• Boiling Point: 235.5°C (rough estimate)
• Flash Point: 251.2 °C
• Appearance: White to off-white/Powder
• Density: 1.3293 (rough estimate)
• Vapor Pressure: 1.42E-09mmHg at 25°C
• Refractive Index: 1.4330 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 3.13±0.10(Predicted)
• Water Solubility: Slightly miscible with water.
• CAS DataBase Reference: 4-Hydroxyphthalic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxyphthalic acid(610-35-5)
• EPA Substance Registry System: 4-Hydroxyphthalic acid(610-35-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25
• TSCA: Yes
• Hazardous Substances Data: 610-35-5(Hazardous Substances Data)

Usage

Description

4-Hydroxyphthalic acid is an organic compound with the chemical formula C8H6O4. It is a white crystalline solid that is soluble in water and has a molecular weight of 166.14 g/mol. It is an important intermediate in the synthesis of various chemical compounds and has a wide range of applications in different industries.

Uses

Used in Chemical Synthesis:
4-Hydroxyphthalic acid is used as a precursor to prepare 3,5-dichloro-4-hydroxyphthalic acid using the reagent aqueous acetic acid and chlorine. 4-Hydroxyphthalic acid is further used in the synthesis of various chemical compounds, such as dyes, pigments, and pharmaceuticals.
Used in Pharmaceutical Industry:
4-Hydroxyphthalic acid is used as a starting material in the manufacture of N-(4-carboxyphenyl)-4-acetoxyphthalimide, which is an important intermediate in the synthesis of various pharmaceutical compounds. 4-Hydroxyphthalic acid has potential applications in the development of drugs for the treatment of various diseases.

InChI:InChI=1/C8H6O5/c9-4-1-2-5(7(10)11)6(3-4)8(12)13/h1-3,9H,(H,10,11)(H,12,13)/p-2

Upstream product

• 85-44-9 phthalic anhydride 
• 89-20-3 4-chlorophthalic acid 
• 89-08-7 4-sulfophthalic acid 
• 1885-13-8 4-methoxyphthalic acid 
• 64139-21-5 Diethyl 4-hydroxyphthalate 
• 134-08-7 4-sulpho-phthalic anhydride 
• 27563-65-1 3-chlorobenzene-1,2-dicarboxylic acid 
• 73416-44-1 2,3-dichloro-1,4-naphthoquinone-6-sulfonic acid 
• 85-76-7 8-acetylamino-5-amino-naphthalene-2-sulfonic acid 
• 22572-84-5 diethyl 4-aminophthalate 
• 483-84-1 8-hydroxy-5,7-dinitro-2-naphthalenesulfonic acid 
• 95-65-8 3,4-Dimethylphenol 
• 4685-47-6 3,4-dimethylanisole 
• 6245-57-4 4-methoxy-2-methylbenzoic acid 

Downstream Products

• 22479-95-4 dimethyl 4-hydroxyphthalate 
• 22895-22-3 4-ethoxyphthalic acid 
• 55104-35-3 5-hydroxy-2-benzofuran-1-(3H)-one 
• 27550-59-0 4-hydroxyphthalic anhydride 
• 99-06-9 3-Carboxyphenol 
• 22895-19-8 dimethyl 4-methoxyphtalate 
• 109803-51-2 3,5-dichloro-4-hydroxyphthalic acid 
• 1885-13-8 4-methoxyphthalic acid 
• 4112-65-6 5-hydroxy-2-methylisoindoline-1,3-dione 
• 124-38-9 carbon dioxide 
• 64139-21-5 Diethyl 4-hydroxyphthalate 

Relevant articles and documents

Efficient synthesis of 4-substituted-ortho-phthalaldehyde analogues: Toward the emergence of new building blocks

4-Methoxy-ortho-phthalaldehyde and 4-hydroxy-ortho-phthalaldehyde are potentially useful molecules for fluorimetric analysis of a variety of amines and for the elaboration of complex molecular architectures. Nevertheless, literature generally describes their synthesis in very low yield (below 5%), mainly due to the inefficiency of the last oxidation step. In this paper, we report a reliable synthesis of 4-substituted-ortho-phthalaldehyde analogues in 51% overall yield owing to the addition of a protecting step of the unstable key intermediate 4,5-dihydroisobenzofuran-5-ol. Oxidation and deprotection steps were also studied in order to provide an effective availability of these two dialdehyde compounds that may increase their future applications.

A hydroxy benzoic anhydride preparation method

The invention discloses a preparation method of hydroxy benzene anhydride. The preparation method comprises the following steps: mixing nitrophthalonitrile and an organic solvent, adding alkali and nitrite, performing heating and a reflux reaction, and performing aftertreatment so as to obtain hydroxyl phthalonitrile; mixing the hydroxyl phthalonitrile and a KOH aqueous solution, performing heating, reflux and filtration, collecting filtrate, after the filtrate is cooled, regulating the pH to be 1, performing multiple extraction, taking an extraction liquid, and performing aftertreatment so as to obtain hydroxyl phthalic acid; and finally performing vacuum sublimation on the hydroxyl phthalic acid so as to obtain the hydroxy benzene anhydride. The simple preparation method of the hydroxy benzene anhydride, provided by the invention, is mild in reaction conditions, simple and convenient to operate, easy to control, low in equipment requirements and very high in yield.