61040-77-5

Basic information

• Product Name: Silane, trimethyl[(3,4,5-trimethoxyphenyl)methoxy]-
• CAS NO: 61040-77-5
• Molecular Formula: C13H22O4Si
• Molecular Weight: 270.401
• Mol File: 61040-77-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Silane, trimethyl[(3,4,5-trimethoxyphenyl)methoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, trimethyl[(3,4,5-trimethoxyphenyl)methoxy]-(61040-77-5)
• EPA Substance Registry System: Silane, trimethyl[(3,4,5-trimethoxyphenyl)methoxy]-(61040-77-5)

Safety Data

• Hazardous Substances Data: 61040-77-5(Hazardous Substances Data)

Upstream product

• 3840-31-1 (3,4,5-trimethoxyphenyl)methanol 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 75-77-4 chloro-trimethyl-silane 

Downstream Products

• 3840-31-1 (3,4,5-trimethoxyphenyl)methanol 
• 185249-91-6 (E)-2-(3',4'-dimethoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethene 
• 108853-09-4 3,3',4,4',5-pentamethoxybibenzyl 
• 158782-26-4 1-(3,4-dimethoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethanol 
• 7402-30-4 2-(3,4,5-trimethyloxy)benzylmalonic acid diethyl ester 

Relevant articles and documents

An asymmetric Salamo-based Zn complex supported on Fe3O4MNPs: a novel heterogeneous nanocatalyst for the silyl protection and deprotection of alcohols under mild conditions

In this study, a magnetic asymmetric Salamo-based Zn complex (H2L = salen type di-Schiff bases)-supported on the surface of modified Fe3O4(Fe3O4@H2L-Zn) as a new catalyst was designed and characterizedvianumerous analytical techniques such as FT-IR spectroscopy, XRD, EDS, ICP-AES, SEM, TEM, TGA and VSM. An efficient and sustainable synthetic protocol has been presented for the synthesis of silyl ether substructuresviathe silyl protection of alcohols under mild conditions. The synthetic protocol involves a two-component solvent-free reaction between various hydroxyl-bearing substrates and hexamethyldisilazane (HMDS) as an inexpensive silylating agent using Fe3O4@H2L-Zn MNPs as a magnetically separable, recyclable and reusable heterogeneous catalyst. Fe3O4@H2L-Zn MNPs were also applied for the removal of silyl protecting groups from hydroxyl functions using water in CH2Cl2under green conditions. The catalyst demonstrated good to excellent catalytic yield efficiency for both the reactions compared to the commercial metal-based catalysts under green conditions for a wide range of substrates.

Simple synthesis of 5-substituted resorcinols: A revisited family of interesting bioactive molecules

The reaction of 3,5-dimethoxybenzyl trimethylsilyl ether (3) with different aldehydes (n-PrCHO, n-C11H23CHO, MeCHO, PhCHO) in the presence of lithium powder and a catalytic amount of naphthalene (4 mol %) gave, after hydrolysis, the expected alcohols 4 in moderate yields. The dehydroxylation of these compounds through the corresponding mesylates 5 or directly from benzylic derivatives by catalytic hydrogenation, afforded compounds 6, which are finally demethylated to yield 5-alkyl-3,5-dihydroxyresorcinols, such as olivetol (7a), grevillol (7b), 1,3-dihydroxy-5-propylbenzene (7c), or dihydropinosilvine (7d). Dehydration of alcohol derivatives 4 followed by demethylation led to hydroxylated stilbene-type structures, such as pinosilvine (9d), resveratrol (9e), or piceatannol (9f), which in some cases can be hydrogenated to give saturated molecules such as combretastanin B-4 tetramethyl ether (6f) or chrysotobibenzyl (6g). Finally, when the naphthalene-catalyzed lithiation of compound 3 was performed in the presence of other electrophiles [Me3SiCl, t-BuCHO, CH3(CH2)4CHO, 4-Me3SiOC6H4CHO, (CH2)5CO, PhN = C = O, PhN = CHPh], the expected reaction products 12 were isolated, after hydrolysis.