61100-12-7

Basic information

• Product Name: 5-(4-NITROPHENYL)THIOPHENE-2-CARBOXYLICACIDMETHYLESTER,96%
• Synonyms: 5-(4-NITROPHENYL)THIOPHENE-2-CARBOXYLICACIDMETHYLESTER,96%
• CAS NO: 61100-12-7
• Molecular Formula: C₁₂H₉NO₄S
• Molecular Weight: 263.27
• Mol File: 61100-12-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(4-NITROPHENYL)THIOPHENE-2-CARBOXYLICACIDMETHYLESTER,96%(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-NITROPHENYL)THIOPHENE-2-CARBOXYLICACIDMETHYLESTER,96%(61100-12-7)
• EPA Substance Registry System: 5-(4-NITROPHENYL)THIOPHENE-2-CARBOXYLICACIDMETHYLESTER,96%(61100-12-7)

Safety Data

• Hazardous Substances Data: 61100-12-7(Hazardous Substances Data)

Upstream product

• 2888-10-0 β-Chlor-p-nitro-zimtaldehyd 
• 124-41-4 sodium methylate 
• 623-51-8 ethyl 2-sulfanylacetate 
• 106098-23-1 (Z)-3-chloro-3-(4-nitrophenyl)acrylaldehyde 
• 2365-48-2 Methyl thioglycolate 
• 59156-21-7 2-(4-nitrophenyl)thiophene 
• 1052113-14-0 [5-(4-Nitro-phenyl)-thiophen-2-yl]-oxo-acetic acid ethyl ester 
• 62224-19-5 5-bromo-2-thiophenecarboxylic acid methyl ester 
• 24067-17-2 4-nitrophenylboronic acid 
• 7311-63-9 5-bromothiophene-2-carboxylic acid 

Downstream Products

• 69202-25-1 5-(4-nitro-phenyl)-thiophene-2-carboxylic acid hydrazide 
• 80387-66-2 5-(4-Amino-phenyl)-thiophene-2-carboxylic acid methyl ester 
• 80387-65-1 5-<4-(acetylamino)phenyl>-2-(methoxycarbonyl)thiophene 
• 80387-79-7 5-(4-nitrophenyl)thiophene-2-carboxylic acid 

Relevant articles and documents

Synthesis, characterization, and biological evaluation of new derivatives targeting MbtI as antitubercular agents

Tuberculosis (TB) causes millions of deaths every year, ranking as one of the most dangerous infectious diseases worldwide. Because several pathogenic strains of Mycobacterium tuberculosis (Mtb) have developed resistance against most of the established anti-TB drugs, new therapeutic options are urgently needed. An attractive target for the development of new antitubercular agents is the salicylate synthase MbtI, an essential enzyme for the mycobacterial siderophore biochemical machinery, absent in human cells. A set of analogues of I and II, two of the most potent MbtI inhibitors identified to date, was synthesized, characterized, and tested to elucidate the structural requirements for achieving an efficient MbtI inhibition and a potent antitubercular activity with this class of compounds. The structure-activity relationships (SAR) here discussed evidenced the importance of the furan as part of the pharmacophore and led to the preparation of six new compounds (IV-IX), which gave us the opportunity to examine a hitherto unexplored position of the phenyl ring. Among them emerged 5-(3-cyano-5-(trifluoromethyl)phenyl)furan-2-carboxylic acid (IV), endowed with comparable inhibitory properties to the previous leads, but a better antitubercular activity, which is a key issue in MbtI inhibitor research. Therefore, compound IV offers promising prospects for future studies on the development of novel agents against mycobacterial infections.

New Rearrangements of Arylhydrazones in Polyphosphoric Acid: Extension to the Thiophene and Indole Series. 5

The behavior toward polyphosphoric acid of arylhydrazones of a few heterocyclic carbonyl compounds of the thiophene and indole series is described.The phenylhydrazone and 2,6-dimethylphenylhydrazone of ethyl α-thienylglyoxylate gave ethyl 4- and 5-(4-aminoaryl)-α-thienylglyoxylate, arising from two different sigmatropic rearrangements.The N,3,5-trimethylphenylhydrazone of 2-methylindole-3-carboxaldehyde afforded the 4--2-methylindole-3-carboxaldehyde resulting from a sigmatropic rearrangement, while the 2,6-dimethylphenylhydrazone of the same carbonyl compound unexpectedly gave the 3-(4-amino-3,5-dimethylphenyl)-2-methylindole-3-carboxaldehyde generated through a sigmatropic reaction.Chemical evidences are given for the assigned structures.