61249-00-1 Usage
Description
Oxirane, ((1-naphthalenyloxy)methyl)-, (S)-, also known as S-(+)-α-Naphthyl Glycidyl Ether, is a chiral organic compound characterized by the presence of an oxirane (epoxide) group and a naphthalene moiety. Oxirane, ((1-naphthalenyloxy)methyl)-, (S)exhibits a specific stereochemistry, with the (S)-configuration, which is crucial for its applications.
Uses
Used in Pharmaceutical Industry:
Oxirane, ((1-naphthalenyloxy)methyl)-, (S)is used as a key intermediate in the synthesis of Naftopidil (N213500) enantiomers. Naftopidil is a selective α1A-adrenergic receptor antagonist used in the treatment of benign prostatic hyperplasia (BPH) and other urological conditions. The (S)-enantiomer of Naftopidil is known to have a higher affinity for the α1A-adrenergic receptor, making it a more effective therapeutic agent.
The use of Oxirane, ((1-naphthalenyloxy)methyl)-, (S)in the preparation of Naftopidil enantiomers allows for the production of a more targeted and effective medication, improving patient outcomes and providing a more precise treatment option for urological conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 61249-00-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,2,4 and 9 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 61249-00:
(7*6)+(6*1)+(5*2)+(4*4)+(3*9)+(2*0)+(1*0)=101
101 % 10 = 1
So 61249-00-1 is a valid CAS Registry Number.
61249-00-1Relevant articles and documents
Asymmetric Hydrolytic and Aminolytic Kinetic Resolution of Racemic Epoxides using Recyclable Macrocyclic Chiral Cobalt(III) Salen Complexes
Tak, Rajkumar,Kumar, Manish,Menapara, Tusharkumar,Gupta, Naveen,Kureshy, Rukhsana I.,Khan, Noor-ul H.,Suresh
supporting information, p. 3990 - 4001 (2017/11/22)
New chiral macrocyclic cobalt(III) salen complexes were synthesized and used as catalyst for the asymmetric kinetic resolution (AKR) of terminal epoxides and glycidyl ethers with aromatic/aliphatic amines and water as nucleophiles. This is the first occasion where a Co(III) salen complex demonstrated its ability to catalyze AKR as well as hydrolytic kinetic resolution (HKR) reactions. Excellent enantiomeric excesses of the epoxides, the corresponding amino alcohols and diols (upto 99%) with quantitative yields were achieved by using the chiral Co(III) salen complexes in dichloromethane at room temperature. This protocol was further extended for the synthesis of two important drug molecules, i.e., (S)-propranolol and (R)-naftopidil. The catalytic system was also explored for the synthesis of chirally pure diols and chiral cyclic carbonates using carbon dioxide as a greener renewable C1 source. The catalyst was recycled for upto 5 catalytic cycles with retention of enantioselectivity. (Figure presented.).