613-18-3 Usage
Description
2,3-Dichloroquinoline is an organic compound characterized by the presence of two chlorine atoms at the 2nd and 3rd positions on the quinoline ring. It is a versatile intermediate in organic synthesis and possesses unique chemical properties that make it suitable for various applications.
Uses
Used in Pharmaceutical Industry:
2,3-Dichloroquinoline is used as a reactant in the preparation of α-carbolines from 2,3-dichloropyridines and substituted anilines. These α-carbolines are important due to their potential therapeutic applications, including their use as antidepressants, antipsychotics, and anti-Parkinson's agents. The synthesis of these compounds is facilitated by the reactivity of the 2,3-dichloropyridine moiety, which allows for the formation of the desired α-carboline structures.
Additionally, 2,3-dichlorquinoline can be used as a building block in the synthesis of other bioactive compounds, contributing to the development of new drugs and therapeutic agents. Its unique structure and reactivity make it a valuable component in the design and synthesis of novel pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 613-18-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,1 and 3 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 613-18:
(5*6)+(4*1)+(3*3)+(2*1)+(1*8)=53
53 % 10 = 3
So 613-18-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H5Cl2N/c10-7-5-6-3-1-2-4-8(6)12-9(7)11/h1-5H
613-18-3Relevant articles and documents
Synthesis, molecular docking study, and evaluation of the antiproliferative action of a new group of propargylthio- and propargylselenoquinolines
Marciniec, Krzysztof,Latocha, Ma?gorzata,Boryczka, Stanis?aw,Kurczab, Rafa?
, p. 3468 - 3477 (2014/06/24)
This study describes the synthesis of a new group of halogenopropargylthio- , dipropargylthio-, and halogenopropargylseleno-quinoline derivatives. The ability of all of the synthesized compounds to inhibit the proliferation of the T-47D, MCF-7, MDA-MB-231, and SNB-19 cell lines was determined with the WST-1 assay. The normal fibroblast cell line (HFF-1) was used as a control. The cytotoxic properties of these new, modified propargylquinoline derivatives were comparable to those of cisplatin. The most active compounds, 4,7-dipropargylthiquinoline (8b) and 7-chloro-4-propargylselenoquinoline (5b), were docked into the binding site of human CYP1A1 and CYP1B1. Our data indicate that these derivatives may present promising chemotherapeutic agents, possibly targeting CYP1s pathway.
From 2,3-, 2,6-, 3,4- and 4,6-dichloroquinolines to isomeric chloroquinolinesulfonyl chlorides
Marciniec, Krzysztof,Maslankiewicz, Andrzej
experimental part, p. 305 - 316 (2010/08/20)
The action of sodium methanethiolate (in boiling DMF) on x,y-dichloroquinolines (1) (x=3 or 6, y=2 or 4) occured via chlorine ipso-substitution followed by methanethiolato-S-demethylation to yield x,y-quinolinedithiolates 2A which were: i) subjected to S-