6148-18-1 Usage
Description
5-[(4-chlorophenoxy)methyl]-3-[(4-methoxyphenyl)methyl]-1,2,4-oxadiazole is a chemical compound characterized by its unique structure that features a 1,2,4-oxadiazole ring fused with a 4-chlorophenoxymethyl and a 4-methoxyphenylmethyl group. 5-[(4-chlorophenoxy)methyl]-3-[(4-methoxyphenyl)methyl]-1,2,4-oxadiazole exhibits specific chemical properties that make it suitable for various applications in different industries.
Uses
Used in Pharmaceutical Industry:
5-[(4-chlorophenoxy)methyl]-3-[(4-methoxyphenyl)methyl]-1,2,4-oxadiazole is used as a reactant in the synthesis of carboxyflavones, which serve as CysLT1 (LTD4) receptor antagonists. These antagonists are important in the development of drugs targeting inflammatory diseases, as they can help modulate the immune response and alleviate symptoms associated with such conditions.
Used in Chemical Synthesis:
In the field of chemical synthesis, 5-[(4-chlorophenoxy)methyl]-3-[(4-methoxyphenyl)methyl]-1,2,4-oxadiazole can be utilized as an intermediate or building block for the creation of more complex molecules with potential applications in various industries, such as materials science, agrochemicals, and specialty chemicals.
Used in Research and Development:
5-[(4-chlorophenoxy)methyl]-3-[(4-methoxyphenyl)methyl]-1,2,4-oxadiazole can also be employed in research and development settings, where it may be used to study the properties and behavior of 1,2,4-oxadiazole-containing molecules. This can lead to the discovery of new applications and advancements in the understanding of these types of chemical structures.
Check Digit Verification of cas no
The CAS Registry Mumber 6148-18-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,1,4 and 8 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 6148-18:
(6*6)+(5*1)+(4*4)+(3*8)+(2*1)+(1*8)=91
91 % 10 = 1
So 6148-18-1 is a valid CAS Registry Number.
InChI:InChI=1/C17H15ClN2O3/c1-21-14-6-2-12(3-7-14)10-16-19-17(23-20-16)11-22-15-8-4-13(18)5-9-15/h2-9H,10-11H2,1H3
6148-18-1Relevant articles and documents
Selective inhibitors of fibroblast activation protein (FAP) with a xanthine scaffold
Jansen, Koen,De Winter, Hans,Heirbaut, Leen,Cheng, Jonathan D.,Joossens, Jurgen,Lambeir, Anne-Marie,De Meester, Ingrid,Augustyns, Koen,Van Der Veken, Pieter
supporting information, p. 1700 - 1707 (2014/12/12)
Fibroblast activation protein (FAP) is a serine protease that is selectively expressed in many diseases involving activated stroma, including cancer, arthritis and hepatic and pulmonary fibrosis. FAP is closely related to dipeptidyl peptidase IV (DPPIV), of which many inhibitors are known and several are marketed as drugs. One of these is the xanthine derivative linagliptin. In a broad literature screen amongst reported DPPIV inhibitors, linagliptin was the only druglike compound identified that possessed significant FAP potency. Hence, this compound served as a starting point for a SAR study that aimed to identify structural determinants that selectively increase FAP-potency of linagliptin analogues. By investigating the influence of the substitution pattern on N1, N7 and C8 of the xanthine scaffold, we managed to decouple DPPIV and FAP potency and identified the first selective xanthine-based FAP inhibitors with low micromolar potency. Furthermore, these compounds are the only known FAP-inhibitors that do not rely on a warhead functionality to obtain potencies in this range.
