6149-33-3Relevant articles and documents
pH-sensitive 4,(4-Nitrophenoxy)benzeneamine) derived azo dye: X-ray crystallographic, DFT and electrochemical studies
Akhter, Zareen,Perveen, Fouzia,Qamar, Samina,Yousuf, Sammer
, (2020)
A novel nitro terminated azo dye, (E)-3-((4-(4-nitrophenoxy)phenyl)diazenyl)-[1,1′-biphenyl]-4-ol (1), was produced by coupling biphenyl-4-ol with 4,(4-Nitrophenoxy)benzeneamine) and was characterized by various spectroscopic and XRD technique. The chemical structure of the compound (1) has a nitro terminal as an electron-withdrawing moiety (A), a biphenyl ring of coupling part as a proton-donating unit (D), and both groups are linked by an azo group connector. The stimulating pH-controlled absorption behavior of chemosensor was investigated using UV/VIS spectroscopic technique. It was observed that synthesized dye (1) has high sensitivity in pH range from 7.9 to 10.46 and could be applied as a selective ‘naked-eye’ colorimetric sensor for H+ ion concentration, as it exhibited a very strong hyperchromic shift in the absorption band from 399 nm to 521 nm with a significant color change from yellow to red. The sensitivity of chemosensor was observed to be fully reversible and rapid which enhance its chances of practical implicitly. Further, DFT simulations were performed using ADF-Modeling suite 2019, to get an idea of relevance with experiments. Additionally, redox behavior of the (1) dye was also investigated by employing cyclic voltammetry using 0.1M TBAP as supporting electrolyte. Cis–Trans conformational changes were analyzed to investigate the photoisomerization ability of the synthesized dye.
Quinoline or quinazoline compound as well as preparation method and application thereof
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Paragraph 0064; 0165; 0167, (2019/01/23)
The invention relates to quinoline or quinazoline compound as well as a preparation process and application thereof. The structural formula is shown in the description. The quinoline or quinazoline compound can inhibit the activity of PFKFB3 in tumor cells, effectively block activation of key enzymes during a glycolysis process, and inhibit energy supply for tumor cells.
Method for the preparation of diphenyl ether compounds
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Paragraph 0023-0025, (2016/12/01)
The invention relates to a method for preparing a diphenyl ether compound. The method is characterized by comprising the following technical steps of: (1) adding a halogenated benzene derivative and a bis(pinacolato)diboron into a reaction vessel, adding copper chloride or aluminum chloride and 1,2-bi(diphenylphosphine) ethane as a catalyst, then adding alkaline and an organic solvent, and reacting at 25-160 DEG C for 6-24 hours; and (2) after extracting a reaction solution obtained from the step (1) by using ethyl acetate, purifying by a 200-300 meshes silica gel column, pre-eluting the silica gel column by using 20-50 mL of normal hexane, eluting by adopting an eluent at a flow speed of 1-2 mL/min for 3-6 hours, and removing the solvent to obtain the diphenyl ether compound. The method for preparing the diphenyl ether compound, disclosed by the invention, no only overcomes the disadvantage of the use of phenolic substances in a reaction process, but also has the advantages of mild reaction condition and high yield.