61686-79-1

Basic information

• Product Name: 1-BENZYL-3-METHYLURACIL
• Synonyms: 1-BENZYL-3-METHYLURACIL
• CAS NO: 61686-79-1
• Molecular Formula: C₁₂H₁₂N₂O₂
• Molecular Weight: 216.24
• Mol File: 61686-79-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-BENZYL-3-METHYLURACIL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL-3-METHYLURACIL(61686-79-1)
• EPA Substance Registry System: 1-BENZYL-3-METHYLURACIL(61686-79-1)

Safety Data

• Hazardous Substances Data: 61686-79-1(Hazardous Substances Data)

Usage

Common Use

Pharmaceutical intermediate and building block in the synthesis of various drugs

Researched for

Potential antiviral and antitumor properties

Known for

Inhibiting the activity of the enzyme dihydroorotate dehydrogenase

Involvement in

Pyrimidine biosynthesis

Upstream product

• 6832-03-7 5-bromo-3-methyl-2,4(1H,3H)pyrimidinedione 
• 952-92-1 1-Benzyl-1,4-dihydronicotinamide 
• 608-34-4 3-methyluracil 
• 1024-41-5 benzyl tosylate 
• 100-39-0 benzyl bromide 
• 25902-86-7 2-methoxy-4(3H)-pyrimidinone 
• 100-44-7 benzyl chloride 
• 74-88-4 methyl iodide 
• 27460-04-4 2-methoxy-3-methylpyrimidin-4(3H)-one 
• 153865-87-3 1-benzyl-5-iodo-1,2,3,4-tetrahydropyrimidine-2,4-dione 
• 71-43-2 benzene 
• 110-00-9 furan 
• 57712-67-1 1-benzyl-5-bromo-1H-pyrimidine-2,4-dione 
• 1597448-68-4 1-N-benzyl-3-N-methyl-5-iodouracil 

Relevant articles and documents

Palladium-catalyzed direct arylation of 5-halouracils and 5-halouracil nucleosides with arenes and heteroarenes promoted by TBAF

The 1-N-benzyl-5-iodo(or bromo)uracil undergoes Pd-catalyzed [Pd 2(dba)3] direct arylation with benzene and other simple arenes in the presence of TBAF in DMF without the necessity of adding any ligands or additives to give 5-arylate

REDUCTIVE DEBROMINATION OF 5-BROMOURACILS BY 1-BENZYL-1,4-DIHYDRONICOTINAMIDE

N(1)-Unsubstituted 5-bromouracils with or without a substituent in position 6 undergo reductive debromination with ease most likely via a one-electron transfer process upon treatment with 1-benzyl-1,4-dihydronicotinamide under thermal conditions.