62-97-5 Usage
Description
Diphemanil methylsulfate (500 MG) DISCON-TINUED is a potent cholinergic blocking agent, which is a quaternary ammonium anticholinergic agent. It is known for its highly specific action on gastric functions and its effectiveness in treating conditions like Frey's syndrome and peptic ulcer. The drug is also valuable in managing hyperhidrosis and acts as a parasympatholytic bronchodilator agent.
Uses
Used in Pharmaceutical Industry:
Diphemanil methylsulfate (500 MG) DISCON-TINUED is used as an anticholinergic agent for the treatment of Frey's syndrome, a condition characterized by excessive sweating and flushing on the side of the face. It is also used as a parasympatholytic bronchodilator agent, which helps in relaxing the smooth muscles of the airways, providing relief from respiratory conditions.
Used in Gastroenterology:
Diphemanil methylsulfate (500 MG) DISCON-TINUED is used as a treatment for peptic ulcer due to its highly specific action on gastric functions. It helps in decreasing gastric hypermotility and reducing the secretion of stomach acids, which aids in the healing process of the ulcer.
Used in Dermatology:
Diphemanil methylsulfate (500 MG) DISCON-TINUED is used topically for the treatment of hyperhidrosis (excessive sweating). It effectively reduces the secretion of sweat and saliva, providing relief to patients suffering from this condition.
Brand Name:
The brand name for diphemanil methylsulfate is Prantal, which was manufactured by Schering.
Originator
Pranta,Schering,US,1952
Manufacturing Process
(A) Preparation of diphenyl-(N-Methyl-4-Piperidyl)carbinol: to a Grignard
solution prepared from 4.9 grams of magnesium, 100 cc of ether and 31.4
grams of dry omobenzene is added 18.5 grams of 4-benzoyl-Nmethylpiperidine in 200 cc of dry ether. The reaction mixture is heated with
stirring for 4 hours on the steam bath and then decomposed. The organic
layer is separated and the aqueous layer extracted with benzene. The
combined organic extracts are concentrated and the residue, diphenyl-(Nmethyl-4-piperidyl)carbinol, recrystallized from benzene-petroleum ether, MP
130-131°C. The Grignard complex may also be decomposed with ice and
hydrochloric acid and the insoluble hydrochloride of the carbinol isolated
directly.(B) Preparation of diphenyl-(N-Methyl-4-Piperidylidene)methane: the carbinol
can be dehydrated with 60% sulfuric acid. In general, to one part of the
carbinol there is added 10 parts of 60% sulfuric acid. The mixture after
heating for 6 hours is poured onto cracked ice, the solution made alkaline with
dilute sodium hydroxide and the oily basic layer extracted with ether. The
ether extracts after washing with water are dried over sodium sulfate, and after removing the ether, the residue is distilled in vacuo, MP 52°-53°C.(C) Preparation of Final Product: The product from (B) is reacted with
dimethyl sulfate in benzene to give the final product, MP 196°-197°C.
Therapeutic Function
Spasmolytic
Check Digit Verification of cas no
The CAS Registry Mumber 62-97-5 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 2 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 62-97:
(4*6)+(3*2)+(2*9)+(1*7)=55
55 % 10 = 5
So 62-97-5 is a valid CAS Registry Number.
InChI:InChI=1/C20H24N.CH4O4S/c1-21(2)15-13-19(14-16-21)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18;1-5-6(2,3)4/h3-12H,13-16H2,1-2H3;1H3,(H,2,3,4)/q+1;
